Compositions and methods for surface abrasion with frozen particles

• US 20100111831A1
• Filed: 10/31/2008
• Published: 05/06/2010
• Est. Priority Date: 10/31/2008
• Status: Abandoned Application

• Current Assignee: Searete LLC (Intellectual Ventures LLC)
• Original Assignee: Searete LLC (Intellectual Ventures LLC)
• Inventors: Myhrvold, Nathan P., Boyden, Edward S., Wood, Lowell L. JR., Hyde, Roderick A., Sweeney, Elizabeth A., Leuthardt, Eric C., Cook, Daniel B.
• Application Number:
  US12/290,670
• Publication Number:
  US 20100111831A1
• Time in Patent Office: Days
• US Class Current: 424/1.110
• CPC Class Codes: A61K 51/1244 microparticles or nanoparticles, e.g. polymeric nanoparticles
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.

Claims

1. A composition, comprising:

one or more frozen particles including at least one of hydrogen oxide, helium, neon, krypton, argon, xenon, nitrogen, chlorine, bromine, oxygen, air, or carbon dioxide, wherein the one or more frozen particles have at least one major dimension of approximately one centimeter or less; and

one or more reinforcement agents.

2. The composition of claim 1, wherein the one or more frozen particles have at least one major dimension of approximately one centimeter or less, approximately one millimeter or less, approximately one micrometer or less, approximately one nanometer or less, or any value therebetween.

3. The composition of claim 2, wherein the one or more frozen particles have at least one major dimension of approximately ten micrometers or less.

4. The composition of claim 1, wherein the at least one major dimension of the one or more frozen particles includes at least one of radius, diameter, length, width, height, or perimeter.

5. The composition of claim 1, further comprising one or more abrasives.

6. The composition of claim 1, wherein the one or more reinforcement agents include at least one of a natural, artificial, or synthetic agent.

16. The composition of claim 1, wherein the one or more frozen particles further comprise at least one of polyethylene glycol, acetone, ethyl acetate, dimethyl sulfoxide, dimethyl formamide, dioxane, hexamethylphosphorotriamide, perfluorohydrocarbon, methanol, ethanol, tert-butyl alcohol, formic acid, hydrogen fluoride, ammonia, acetic acid, benzene, carbon tetrachloride, acetonitrile, hexane, methylene chloride, carboxylic acid, saline, Ringer'"'"'s solution, lactated Ringer'"'"'s solution, Hartmann'"'"'s solution, acetated Ringer'"'"'s solution, phosphate buffered solution, TRIS-buffered saline solution, Hank'"'"'s balanced salt solution, Earle'"'"'s balanced salt solution, standard saline citrate, HEPES-buffered saline, dextrose, glucose, or diethyl ether.

17. The composition of claim 1, further comprising at least one therapeutic agent.

20. The composition of claim 17, wherein the at least one therapeutic agent includes one or more of a prodrug or precursor compound.

21. The composition of claim 1, further comprising at least one of a polymer, biopolymer, nanoparticle, or detection material.

22. The composition of claim 21, wherein the detection material includes at least one electronic identification device.

23. The composition of claim 22, wherein the at least one electronic identification device includes at least one radio frequency identification device.

24. The composition of claim 21, wherein the detection material includes at least one radioactive element.

25. The composition of claim 24, wherein the at least one radioactive element includes one or more of ³²P, ³⁵S, ¹³C, ¹³¹I, ¹⁹¹Ir, ¹⁹²Ir, ¹⁹³Ir, ²⁰Tl, or ³H.

26. The composition of claim 21, wherein the detection material includes at least one colorimetric substance.

27. The composition of claim 26, wherein the at least one colorimetric substance includes one or more of an inorganic, organic, biological, natural, artificial, or synthetic substance.

28. The composition of claim 26, wherein the at least one calorimetric substance includes one or more of a dye, pigment, or light-emitting substance.

29. The composition of claim 28, wherein the light-emitting substance includes at least one of a fluorescent substance, phosphorescent substance, or quantum dot.

30. The composition of claim 26, wherein the at least one colorimetric substance is biocompatible.

31. The composition of claim 21, wherein the detection material includes at least one of a diamagnetic particle, ferromagnetic particle, paramagnetic particle, super paramagnetic contrast agent, or other magnetic particle.

33. The composition of claim 1, wherein the one or more frozen particles include a plurality of frozen particles that are approximately uniform with regard to size, shape, weight, or density.

34. The composition of claim 1, formulated to be administered by high velocity impact.

35. The composition of claim 1, formulated to be administered by one or more devices.

36. The composition of claim 1, further comprising at least one pharmaceutically-acceptable carrier or excipient.

37. The composition of claim 1, further comprising one or more explosive materials.

38. The composition of claim 37, wherein the one or more explosive materials include at least one of a high explosive or a low explosive.

39. The composition of claim 37, wherein the one or more explosive materials include at least one of carbon dioxide, nitroglycerine, or a reactive metal.

7-15. -15. (canceled)

18-19. -19. (canceled)

32. (canceled)

40-41. -41. (canceled)

42. A composition, comprising:

one or more frozen particles including at least one of hydrogen oxide, helium, neon, krypton, argon, xenon, nitrogen, chlorine, bromine, oxygen, air, or carbon dioxide, wherein the one or more frozen particles have at least one major dimension of approximately one centimeter or less; and

one or more explosive materials.

43. The composition of claim 42, wherein the one or more frozen particles have at least one major dimension of approximately one centimeter or less, approximately one millimeter or less, approximately one micrometer or less, approximately one nanometer or less, or any value therebetween.

44. The composition of claim 43, wherein the one or more frozen particles have at least one major dimension of approximately ten micrometers or less.

45. The composition of claim 42, wherein the at least one major dimension of the one or more frozen particles includes at least one of radius, diameter, length, width, height, or perimeter.

46. The composition of claim 42, further comprising one or more abrasives.

47. The composition of claim 42, further comprising one or more reinforcement agents.

58. The composition of claim 42, wherein the one or more frozen particles further comprise at least one of polyethylene glycol, acetone, ethyl acetate, dimethyl sulfoxide, dimethyl formamide, dioxane, hexamethylphosphorotriamide, perfluorohydrocarbon, methanol, ethanol, tert-butyl alcohol, formic acid, hydrogen fluoride, ammonia, acetic acid, benzene, carbon tetrachloride, acetonitrile, hexane, methylene chloride, carboxylic acid, saline, Ringer'"'"'s solution, lactated Ringer'"'"'s solution, Hartmann'"'"'s solution, acetated Ringer'"'"'s solution, phosphate buffered solution, TRIS-buffered saline solution, Hank'"'"'s balanced salt solution, Earle'"'"'s balanced salt solution, standard saline citrate, HEPES-buffered saline, dextrose, glucose, or diethyl ether.

59. The composition of claim 42, further comprising at least one therapeutic agent.

60. The composition of claim 59, wherein the at least one therapeutic agent includes one or more of a prodrug or precursor compound.

63. The composition of claim 42, further comprising at least one of a polymer, biopolymer, nanoparticle, or detection material.

64. The composition of claim 63, wherein the detection material includes at least one electronic identification device.

65. The composition of claim 64, wherein the at least one electronic identification device includes at least one radio frequency identification device.

66. The composition of claim 63, wherein the detection material includes at least one radioactive element.

67. The composition of claim 66, wherein the at least one radioactive element includes one or more of ³²P, ³⁵S, ¹³C, ¹³¹I, ¹⁹¹Ir, ¹⁹²Ir, ¹⁹³Ir, ²⁰¹Tl, or ³H.

68. The composition of claim 63, wherein the detection material includes at least one calorimetric substance.

69. The composition of claim 68, wherein the at least one calorimetric substance includes one or more of an inorganic, organic, biological, natural, artificial, or synthetic substance.

70. The composition of claim 68, wherein the at least one calorimetric substance includes one or more of a dye, pigment, or light-emitting substance.

71. The composition of claim 70, wherein the light-emitting substance includes at least one of a fluorescent substance, phosphorescent substance, or quantum dot.

72. The composition of claim 68, wherein the at least one calorimetric substance is biocompatible.

73. The composition of claim 63, wherein the detection material includes at least one of a diamagnetic particle, ferromagnetic particle, paramagnetic particle, super paramagnetic contrast agent, or other magnetic particle.

75. The composition of claim 42, wherein the one or more frozen particles include a plurality of frozen hydrogen oxide particles that are approximately uniform with regard to size, shape, weight, or density.

76. The composition of claim 42, formulated to be administered by high velocity impact.

77. The composition of claim 42, formulated to be administered by one or more devices.

78. The composition of claim 42, further comprising at least one pharmaceutically-acceptable carrier or excipient.

79. The composition of claim 42, wherein the one or more explosive materials include at least one of a high explosive or a low explosive.

80. The composition of claim 79, wherein the one or more explosive materials include at least one of carbon dioxide, nitroglycerine, or a reactive metal.

48-57. -57. (canceled)

61-62. -62. (canceled)

74. (canceled)

81-256. -256. (canceled)