Compositions and methods for surface abrasion with frozen particles

• US 20100111833A1
• Filed: 02/26/2009
• Published: 05/06/2010
• Est. Priority Date: 10/31/2008
• Status: Active Grant

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: Searete LLC (Intellectual Ventures LLC)
• Inventors: Myhrvold, Nathan P., Boyden, Edward S., Wood, Lowell L. JR., Hyde, Roderick A., Sweeney, Elizabeth A., Leuthardt, Eric C., Cook, Daniel B.
• Granted Patent: US 9,060,934 B2
• Time in Patent Office: Days
• US Class Current: 424/1.110
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/00 Medicinal preparations containing organic active ingredients
• CPC Class Codes: A61K 31/10 Sulfides; Sulfoxides; Sulfones
• CPC Class Codes: A61K 31/337 having four-membered rings, e.g. taxol
• CPC Class Codes: A61K 31/70 Carbohydrates; Sugars; Derivatives thereof sorbitol A61K31/047
• CPC Class Codes: A61K 31/7088 Compounds having three or more nucleosides or nucleotides
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61K 39/00 Medicinal preparations containing antigens or antibodies materials for immunoassay G01N33/53
• CPC Class Codes: A61K 41/0004 Homeopathy; Vitalisation; Resonance; Dynamisation, e.g. esoteric applications; Oxygenation of blood
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 49/1818 particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
• CPC Class Codes: A61K 51/12 characterised by a special physical form, e.g. emulsion, microcapsules, liposomes , characterized by a special physical form, e.g. emulsions, dispersions, microcapsules liposomes A61K51/1234
• CPC Class Codes: A61K 51/1244 microparticles or nanoparticles, e.g. polymeric nanoparticles
• CPC Class Codes: A61K 9/0021 Intradermal administration, e.g. through microneedle arrays, needleless injectors mechanical aspects A61M
• CPC Class Codes: A61K 9/08 Solutions composition of solutions A61K47/00
• CPC Class Codes: A61K 9/1611 Inorganic compounds
• CPC Class Codes: A61K 9/1641 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
• CPC Class Codes: A61K 9/1664 Compounds of unknown constitution, e.g. material from plants or animals oils, fats, waxes, shellac A61K9/1617
• CPC Class Codes: A61K 9/1688 resulting in pure drug agglomerate optionally containing up to 5% of excipient
• CPC Class Codes: A61K 9/19 lyophilised , i.e. freeze-dried, solutions or dispersions lyophilised products with subsequent particle size reduction A61K9/14; granules or pellets made by lyphilisation A61K9/1682; solid oral dosage forms made by lyophilisation A61K9/2095; lyophilisation additives A61K47/00

Abstract

Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.

Claims

1-78. -78. (canceled)

79. A method for abrasion of at least one biological tissue surface of a subject, comprising:

delivering at least one composition to at least one surface of at least one biological tissue of a subject in a manner sufficient to abrade the at least one surface of the at least one biological tissue;

wherein the at least one composition includes one or more frozen particles, including at least one of polyethylene glycol, acetone, ethyl acetate, dimethyl sulfoxide, dimethyl formamide, dioxane, hexamethylphosphorotriamide, perfluorohydrocarbon, methanol, ethanol, tert-butyl alcohol, formic acid, hydrogen fluoride, ammonia, acetic acid, benzene, carbon tetrachloride, acetonitrile, hexane, methylene chloride, carboxylic acid, saline, Ringer'"'"'s solution, lactated Ringer'"'"'s solution, Hartmann'"'"'s solution, acetated Ringer'"'"'s solution, phosphate buffered solution, TRIS-buffered saline solution, Hank'"'"'s balanced salt solution, Earle'"'"'s balanced salt solution, standard saline citrate, HEPES-buffered saline, dextrose, glucose, or diethyl ether;

wherein the one or more frozen particles have at least one major dimension of approximately one centimeter or less.

80. The method of claim 79, wherein the at least one composition further comprises one or more reinforcement agents.

81. The method of claim 79, wherein delivering at least one composition to at least one biological tissue includes propelling the composition toward the at least one biological tissue.

84. The method of claim 81, wherein the at least one composition is propelled to a predetermined velocity for delivery of the at least one composition to a desired location of the at least one biological tissue.

90. The method of claim 79, wherein the delivering at least one composition to at least one biological tissue includes propelling, ejecting, or accelerating multiple frozen particles toward the at least one biological tissue.

96. The method of claim 79, further comprising extracting or collecting material from the at least one abraded surface of at least one biological tissue.

100. The method of claim 79, wherein the at least one biological tissue is located in at least one of in situ, in vitro, in vivo, in utero, in planta, in silico, or ex vivo.

102. The method of claim 79, wherein the at least one biological tissue is located in at least one tissue or organ related to transplantation.

103. The method of claim 102, wherein the at least one tissue or organ related to transplantation includes at least one donor or recipient tissue or organ.

104. The method of claim 103, wherein the at least one donor includes at least one cadaver.

105. The method of claim 100, wherein the at least one biological tissue is ingested by at least one subject.

107. The method of claim 100, wherein the at least one biological tissue includes at least one cell mass.

108. The method of claim 107, wherein the at least one cell mass includes at least one of a scar, pore, pit, eschar, granuloma, keloid, artheromatous plaque, abscess, pustule, infected tissue, scaling, hair follicle, necrotic tissue, stratum corneum, wrinkle, wound, tumor, skin structure, nevus, cyst, lesion, callus, neoplastic tissue, gangrenous tissue, or cellular deposit.

109. The method of claim 107, wherein the at least one cell mass includes at least one benign or malignant tumor.

110. The method of claim 109, wherein the at least one benign or malignant tumor relates to one or more of a melanoma, lymphoma, leukemia, sarcoma, blastoma, or carcinoma.

111. The method of claim 107, wherein the at least one cell mass is related to at least one blood clot, microorganism accumulation, blood vessel obstruction, duct obstruction, bowel obstruction, infection, gangrene, connective tissue destruction, tissue or organ damage, injury, white blood cell accumulation, or cancer.

112. The method of claim 79, further comprising delivering to the at least one biological tissue at least one of a polymer, biopolymer, nanoparticle, or detection material.

116. The method of claim 112, wherein the detection material includes at least one electronic identification device.

117. The method of claim 116, wherein the at least one electronic identification device includes at least one radio frequency identification device.

118. The method of claim 112, wherein the detection material includes at least one radioactive element.

120. The method of claim 112, wherein the detection material includes at least one colorimetric substance.

122. The method of claim 120, wherein the at least one calorimetric substance includes one or more of a dye, pigment, or light-emitting substance.

123. The method of claim 122, wherein the light-emitting substance includes at least one of a fluorescent substance, phosphorescent substance, or quantum dot.

125. The method of claim 112, wherein the detection material includes at least one of a diamagnetic particle, ferromagnetic particle, paramagnetic particle, super paramagnetic contrast agent, or other magnetic particle.

126. The method of claim 79, wherein the subject includes at least one invertebrate or vertebrate animal.

129. The method of claim 126, wherein the subject includes at least one livestock, pet, undomesticated herd animal, wild animal, or product animal.

131. The method of claim 79, wherein the at least one composition further comprises one or more explosive materials.

82-83. -83. (canceled)

85-89. -89. (canceled)

91-95. -95. (canceled)

97-99. -99. (canceled)

101. (canceled)

106. (canceled)

113-115. -115. (canceled)

119. (canceled)

121. (canceled)

124. (canceled)

127. (canceled)

128. The method of claim 127, wherein the subject includes at least one human.

130. (canceled)

132. A method for debridement of at least one biological tissue of a subject, comprising:

delivering at least one composition to at least one biological tissue of a subject in a manner sufficient to remove dead, damaged or infected tissue of the at least one biological tissue,

wherein the at least one composition includes one or more frozen particles including at least one of polyethylene glycol, acetone, ethyl acetate, dimethyl sulfoxide, dimethyl formamide, dioxane, hexamethylphosphorotriamide, perfluorohydrocarbon, methanol, ethanol, tert-butyl alcohol, formic acid, hydrogen fluoride, ammonia, acetic acid, benzene, carbon tetrachloride, acetonitrile, hexane, methylene chloride, carboxylic acid, saline, Ringer'"'"'s solution, lactated Ringer'"'"'s solution, Hartmann'"'"'s solution, acetated Ringer'"'"'s solution, phosphate buffered solution, TRIS-buffered saline solution, Hank'"'"'s balanced salt solution, Earle'"'"'s balanced salt solution, standard saline citrate, HEPES-buffered saline, dextrose, glucose, or diethyl ether;

wherein the one or more frozen particles have at least one major dimension of approximately one centimeter or less.

133. The method of claim 132, wherein the at least one composition further comprises one or more reinforcement agents.

137. The method of claim 132, wherein the at least one biological tissue is located in at least one of in situ, in vitro, in vivo, in utero, in planta, in silico, or ex vivo.

139. The method of claim 137, wherein the at least one biological tissue is located in at least one tissue or organ related to transplantation.

140. The method of claim 139, wherein the at least one tissue or organ related to transplantation includes at least one donor or recipient tissue or organ.

141. The method of claim 140, wherein the at least one donor includes at least one cadaver.

143. The method of claim 132, wherein the at least one composition further comprises one or more explosive materials.

144. The method of claim 132, wherein the at least one composition further comprises at least one chemical debridement agent including one or more of an enzyme, or urea.

145. The method of claim 144, wherein the enzyme includes at least one of papain, elastase, protease, peptidase, or collagenase.

134. (canceled)

135. The method of claim 134, wherein connective tissue includes at least one loose connective tissue, dense connective tissue, elastic connective tissue, reticular connective tissue, cartilage, or blood.

136. The method of claim 135, wherein the at least one connective tissue includes at least one ligament or tendon.

138. (canceled)

142. (canceled)

146. A method for removing one or more materials from at least one blood vessel of at least one subject, comprising:

delivering at least one composition to at least one blood vessel of a subject in a manner sufficient to remove one or more materials,

wherein the at least one composition includes one or more frozen particles, including at least one of polyethylene glycol, acetone, ethyl acetate, dimethyl sulfoxide, dimethyl formamide, dioxane, hexamethylphosphorotriamide, perfluorohydrocarbon, methanol, ethanol, tert-butyl alcohol, formic acid, hydrogen fluoride, ammonia, acetic acid, benzene, carbon tetrachloride, acetonitrile, hexane, methylene chloride, carboxylic acid, saline, Ringer'"'"'s solution, lactated Ringer'"'"'s solution, Hartmann'"'"'s solution, acetated Ringer'"'"'s solution, phosphate buffered solution, TRIS-buffered saline solution, Hank'"'"'s balanced salt solution, Earle'"'"'s balanced salt solution, standard saline citrate, HEPES-buffered saline, dextrose, glucose, or diethyl ether;

wherein the one or more frozen particles have at least one major dimension of approximately one centimeter or less.

147. The method of claim 146, wherein the at least one composition further comprises one or more reinforcement agents.

148. The method of claim 146, wherein the at least one blood vessel includes at least one artery, vein, or capillary.

149. The method of claim 146, wherein the at least one blood vessel is located in at least one of in situ, in vitro, in vivo, in utero, in planta, in silico, or ex vivo.

151. The method of claim 146, wherein the at least one blood vessel is located in at least one tissue or organ related to transplantation.

152. The method of claim 151, wherein the at least one tissue or organ related to transplantation includes at least one donor or recipient tissue or organ.

153. The method of claim 152, wherein the at least one donor includes at least one cadaver.

154. The method of claim 146, wherein the at least one composition further comprises one or more explosive materials.

150. (canceled)

155. A method for cleaning one or more wounds of a subject, comprising:

delivering at least one composition to one or more wounds in a manner sufficient to clean the one or more wounds,

wherein the at least one composition includes one or more frozen particles, including at least one of polyethylene glycol, acetone, ethyl acetate, dimethyl sulfoxide, dimethyl formamide, dioxane, hexamethylphosphorotriamide, perfluorohydrocarbon, methanol, ethanol, tert-butyl alcohol, formic acid, hydrogen fluoride, ammonia, acetic acid, benzene, carbon tetrachloride, acetonitrile, hexane, methylene chloride, carboxylic acid, saline, Ringer'"'"'s solution, lactated Ringer'"'"'s solution, Hartmann'"'"'s solution, acetated Ringer'"'"'s solution, phosphate buffered solution, TRIS-buffered saline solution, Hank'"'"'s balanced salt solution, Earle'"'"'s balanced salt solution, standard saline citrate, HEPES-buffered saline, dextrose, glucose, or diethyl ether;

wherein the one or more frozen particles have at least one major dimension of approximately one centimeter or less.

156. The method of claim 155, wherein the at least one composition further comprises one or more reinforcement agents.

159. The method of claim 155, wherein the at least one composition further comprises one or more explosive materials.

157-158. -158. (canceled)

160-162. -162. (canceled)