Compositions and methods for therapeutic delivery with frozen particles
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Abstract
Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.
105 Citations
149 Claims
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41. A method of providing at least one therapeutic agent to at least one biological tissue of a subject, comprising:
delivering at least one therapeutic composition to at least one biological tissue, wherein the at least one therapeutic composition includes one or more frozen particles including at least one therapeutic agent and at least one of polyethylene glycol, acetone, ethyl acetate, dimethyl sulfoxide, dimethyl formamide, dioxane, hexamethylphosphorotriamide, perfluorohydrocarbon, methanol, ethanol, tert-butyl alcohol, formic acid, hydrogen fluoride, ammonia, acetic acid, benzene, carbon tetrachloride, acetonitrile, hexane, methylene chloride, carboxylic acid, saline, Ringer'"'"'s solution, lactated Ringer'"'"'s solution, Hartmann'"'"'s solution, acetated Ringer'"'"'s solution, phosphate buffered solution, TRIS-buffered saline solution, Hank'"'"'s balanced salt solution, Earle'"'"'s balanced salt solution, standard saline citrate, HEPES-buffered saline, dextrose, glucose, or diethyl ether. - View Dependent Claims (45, 48, 50, 51, 52, 54, 59, 60, 62, 63, 64, 65, 67, 69, 72, 76, 77, 78, 80, 82, 83, 85, 86, 88, 89, 91, 92)
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93. A method of vaccinating a subject, comprising:
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delivering to at least one biological tissue of a subject at least one therapeutic composition; wherein the at least one therapeutic composition includes one or more frozen particles including at least one vaccine and including at least one of polyethylene glycol, acetone, ethyl acetate, dimethyl sulfoxide, dimethyl formamide, dioxane, hexamethylphosphorotriamide, perfluorohydrocarbon, methanol, ethanol, tert-butyl alcohol, formic acid, hydrogen fluoride, ammonia, acetic acid, benzene, carbon tetrachloride, acetonitrile, hexane, methylene chloride, carboxylic acid, saline, Ringer'"'"'s solution, lactated Ringer'"'"'s solution, Hartmann'"'"'s solution, acetated Ringer'"'"'s solution, phosphate buffered solution, TRIS-buffered saline solution, Hank'"'"'s balanced salt solution, Earle'"'"'s balanced salt solution, standard saline citrate, HEPES-buffered saline, dextrose, glucose, or diethyl ether. - View Dependent Claims (97, 99, 102, 107, 108, 111, 116, 117, 119, 120, 121, 124, 126, 129, 133, 134, 135, 137, 139, 142, 143, 145, 146, 148, 149)
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Specification