STABILIZED THERAPEUTIC AND IMAGING AGENTS
First Claim
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1. A stabilized lipid construct comprising a coated liposome or polymerized vesicle, a targeting entity, therapeutic entity, wherein the coating comprises a stabilizing entity which is associated with the liposome or polymerized vesicle by covalent means and is only on the surface of the liposome or polymerized vesicle.
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Abstract
Stabilized lipid construct comprising a liposome or polymerized vesicle, a targeting entity, a therapeutic entity, and a stabilizing entity are provided, as well as methods for their preparation and use.
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Citations
46 Claims
- 1. A stabilized lipid construct comprising a coated liposome or polymerized vesicle, a targeting entity, therapeutic entity, wherein the coating comprises a stabilizing entity which is associated with the liposome or polymerized vesicle by covalent means and is only on the surface of the liposome or polymerized vesicle.
- 19. A stabilized lipid construct comprising a coated liposome or polymerized vesicle and a therapeutic entity, wherein the coating comprises a stabilizing entity which is associated with the liposome or polymerized vesicle by covalent means and is only on the surface of the liposome or polymerized vesicle.
- 28. A stabilized lipid construct for controlled release of a therapeutic agent, comprising a coated liposome or polymerized vesicle and a therapeutic entity, wherein the coating comprises a stabilizing entity which is associated with the liposome or polymerized vesicle by covalent means and is only on the surface of the liposome or polymerized vesicle.
- 29. A method of treating a patient comprising administering a therapeutic agent to a patient in need thereof in a sufficient amount, said therapeutic agent comprising a stabilized lipid construct, said stabilized lipid construct comprising a coated liposome or polymerized vesicle, a targeting entity, and a therapeutic entity, wherein the coating comprises a stabilizing entity which is associated with the liposome or polymerized vesicle by covalent means and is only on the surface of the liposome or polymerized vesicle.
- 30. A stabilized lipid construct comprising a coated liposome or polymerized vesicle, a targeting entity, and a therapeutic entity, wherein the coating comprises a stabilizing entity which is associated with the liposome or polymerized vesicle by covalent means and is only on the surface of the liposome or polymerized vesicle, and the stabilizing entity is selected from the group consisting of dextran and modified dextran.
- 31. A stabilized lipid construct comprising a coated liposome or polymerized vesicle and a therapeutic entity, wherein the coating comprises a stabilizing entity which is associated with the liposome or polymerized vesicle by covalent means and is only on the surface of the liposome or polymerized vesicle, and the stabilizing entity is selected from the group consisting of dextran and modified dextran.
- 32. A stabilized lipid construct for controlled release of a therapeutic agent, comprising a coated liposome or polymerized vesicle, a targeting entity, and a therapeutic entity, wherein the coating comprises a stabilizing entity which is associated with the liposome or polymerized vesicle by covalent means and is only on the surface of the liposome or polymerized vesicle, and the stabilizing entity is selected from the group consisting of dextran and modified dextran.
Specification