Compositions and methods for surface abrasion with frozen particles

• US 20100111841A1
• Filed: 10/31/2008
• Published: 05/06/2010
• Est. Priority Date: 10/31/2008
• Status: Abandoned Application

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: Searete LLC (Intellectual Ventures LLC)
• Inventors: Myhrvold, Nathan P., Boyden, Edward S., Wood, Lowell L. JR., Hyde, Roderick A., Sweeney, Elizabeth A., Leuthardt, Eric C., Cook, Daniel B.
• Application Number:
  US12/290,658
• Publication Number:
  US 20100111841A1
• Time in Patent Office: Days
• US Class Current: 424/1.290
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/00 Medicinal preparations containing organic active ingredients
• CPC Class Codes: A61K 31/10 Sulfides; Sulfoxides; Sulfones
• CPC Class Codes: A61K 31/337 having four-membered rings, e.g. taxol
• CPC Class Codes: A61K 31/70 Carbohydrates; Sugars; Derivatives thereof sorbitol A61K31/047
• CPC Class Codes: A61K 31/7088 Compounds having three or more nucleosides or nucleotides
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61K 39/00 Medicinal preparations containing antigens or antibodies materials for immunoassay G01N33/53
• CPC Class Codes: A61K 41/0004 Homeopathy; Vitalisation; Resonance; Dynamisation, e.g. esoteric applications; Oxygenation of blood
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 49/1818 particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
• CPC Class Codes: A61K 51/12 characterised by a special physical form, e.g. emulsion, microcapsules, liposomes , characterized by a special physical form, e.g. emulsions, dispersions, microcapsules liposomes A61K51/1234
• CPC Class Codes: A61K 51/1244 microparticles or nanoparticles, e.g. polymeric nanoparticles
• CPC Class Codes: A61K 9/0021 Intradermal administration, e.g. through microneedle arrays, needleless injectors mechanical aspects A61M
• CPC Class Codes: A61K 9/08 Solutions composition of solutions A61K47/00
• CPC Class Codes: A61K 9/1611 Inorganic compounds
• CPC Class Codes: A61K 9/1641 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
• CPC Class Codes: A61K 9/1664 Compounds of unknown constitution, e.g. material from plants or animals oils, fats, waxes, shellac A61K9/1617
• CPC Class Codes: A61K 9/1688 resulting in pure drug agglomerate optionally containing up to 5% of excipient
• CPC Class Codes: A61K 9/19 lyophilised , i.e. freeze-dried, solutions or dispersions lyophilised products with subsequent particle size reduction A61K9/14; granules or pellets made by lyphilisation A61K9/1682; solid oral dosage forms made by lyophilisation A61K9/2095; lyophilisation additives A61K47/00
• CPC Class Codes: A61P 43/00 : Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: Y10T 428/2982 : Particulate matter [e.g., sphere, flake, etc.]

Abstract

Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.

Claims

1. A composition, comprising:

one or more frozen particles including one or more reinforcement agents and at least one of polyethylene glycol, acetone, ethyl acetate, dimethyl sulfoxide, dimethyl formamide, dioxane, hexamethylphosphorotriamide, perfluorohydrocarbon, methanol, ethanol, tert-butyl alcohol, formic acid, hydrogen fluoride, ammonia, acetic acid, benzene, carbon tetrachloride, acetonitrile, hexane, methylene chloride, carboxylic acid, saline, Ringer'"'"'s solution, lactated Ringer'"'"'s solution, Hartmann'"'"'s solution, acetated Ringer'"'"'s solution, phosphate buffered solution, TRIS-buffered saline solution, Hank'"'"'s balanced salt solution, Earle'"'"'s balanced salt solution, standard saline citrate, HEPES-buffered saline, dextrose, glucose, or diethyl ether.

2. The composition of claim 1, wherein the one or more frozen particles have at least one major dimension of approximately one centimeter or less, approximately one millimeter or less, approximately one micrometer or less, approximately one nanometer or less, or any value therebetween.

4. The composition of claim 1, wherein the at least one major dimension of the one or more frozen particles includes at least one of radius, diameter, length, width, height, or perimeter.

5. The composition of claim 1, further comprising at least one of nitrogen, argon, helium, air, oxygen, neon, xenon, krypton, chlorine, bromine, or carbon dioxide.

6. The composition of claim 1, further comprising one or more abrasives.

7. The composition of claim 1, wherein the one or more reinforcement agents include at least one of a natural, artificial, or synthetic agent.

12. The composition of claim 1, wherein the one or more frozen particles further include at least one of amorphous solid water, low density amorphous ice, high density amorphous ice, crystalline ice, very high density amorphous ice, clathrate ice, or hyperquenched glassy water.

13. The composition of claim 1, wherein the one or more frozen particles further include at least one of ice Ic, ice Ih, ice II, ice III, ice IV, ice V, ice VI, ice VII, ice VIII, ice IX, ice X, ice XI, ice XII, ice XIII, or ice XIV.

17. The composition of claim 1, further comprising at least one therapeutic agent.

18. The composition of claim 17, wherein the at least one therapeutic agent includes one or more of a prodrug or precursor compound.

19. The composition of claim 1, further comprising at least one of a polymer, biopolymer, nanoparticle, or detection material.

20. The composition of claim 19, wherein the detection material includes at least one electronic identification device.

21. The composition of claim 20, wherein the at least one electronic identification device includes at least one radio frequency identification device.

22. The composition of claim 19, wherein the detection material includes at least one radioactive element.

23. The composition of claim 22, wherein the at least one radioactive element includes one or more of ³²P, ³⁵S, ¹³C, ¹³¹I, ¹⁹¹Ir, ¹⁹²Ir, ¹⁹³Ir, ²⁰¹Tl, or ³H.

24. The composition of claim 19, wherein the detection material includes at least one colorimetric substance.

25. The composition of claim 24, wherein the at least one calorimetric substance includes one or more of an inorganic, organic, biological, natural, artificial, or synthetic substance.

26. The composition of claim 24, wherein the at least one calorimetric substance includes one or more of a dye, pigment, or light-emitting substance.

27. The composition of claim 26, wherein the light-emitting substance includes at least one of a fluorescent substance, phosphorescent substance, or quantum dot.

28. The composition of claim 24, wherein the at least one calorimetric substance is biocompatible.

29. The composition of claim 19, wherein the detection material includes at least one of a diamagnetic particle, ferromagnetic particle, paramagnetic particle, super paramagnetic contrast agent, or other magnetic particle.

31. The composition of claim 1, wherein the one or more frozen particles include a plurality of frozen particles that are approximately uniform with regard to size, shape, weight, or density.

34. The composition of claim 1, formulated to be administered by high velocity impact.

36. The composition of claim 1, further comprising at least one pharmaceutically-acceptable carrier or excipient.

37. The composition of claim 1, further comprising one or more explosive materials.

38. The composition of claim 37, wherein the one or more explosive materials include at least one of a high explosive or a low explosive.

39. The composition of claim 37, wherein the one or more explosive materials include at least one of carbon dioxide, nitroglycerine, or a reactive metal.

3. (canceled)

8-11. -11. (canceled)

14-16. -16. (canceled)

30. (canceled)

32-33. -33. (canceled)

35. (canceled)

40. A composition, comprising:

one or more frozen particles including one or more explosive materials and at least one of polyethylene glycol, acetone, ethyl acetate, dimethyl sulfoxide, dimethyl formamide, dioxane, hexamethylphosphorotriamide, perfluorohydrocarbon, methanol, ethanol, tert-butyl alcohol, formic acid, hydrogen fluoride, ammonia, acetic acid, benzene, carbon tetrachloride, acetonitrile, hexane, methylene chloride, carboxylic acid, saline, Ringer'"'"'s solution, lactated Ringer'"'"'s solution, Hartmann'"'"'s solution, acetated Ringer'"'"'s solution, phosphate buffered solution, TRIS-buffered saline solution, Hank'"'"'s balanced salt solution, Earle'"'"'s balanced salt solution, standard saline citrate, HEPES-buffered saline, dextrose, glucose, or diethyl ether.

41. The composition of claim 40, wherein the one or more frozen particles have at least one major dimension of approximately one centimeter or less, approximately one millimeter or less, approximately one micrometer or less, approximately one nanometer or less, or any value therebetween.

43. The composition of claim 41, wherein the at least one major dimension of the one or more frozen particles includes at least one of radius, diameter, length, width, height, or perimeter.

44. The composition of claim 40, further comprising at least one of nitrogen, argon, helium, air, oxygen, neon, xenon, krypton, chlorine, bromine, or carbon dioxide.

45. The composition of claim 40, further comprising one or more abrasives.

46. The composition of claim 40, further comprising one or more reinforcement agents.

47. The composition of claim 46, wherein the one or more reinforcement agents include at least one of a natural, artificial, or synthetic agent.

52. The composition of claim 40, wherein the one or more frozen particles further include at least one of amorphous solid water, low density amorphous ice, high density amorphous ice, crystalline ice, very high density amorphous ice, clathrate ice, or hyperquenched glassy water.

53. The composition of claim 40, wherein the one or more frozen particles further include at least one of ice Ic, ice Ih, ice II, ice III, ice IV, ice V, ice VI, ice VII, ice VIII, ice IX, ice X, ice XI, ice XII, ice XIII, or ice XIV.

57. The composition of claim 40, further comprising at least one therapeutic agent.

58. The composition of claim 57, wherein the at least one therapeutic agent includes one or more of a prodrug or precursor compound.

61. The composition of claim 40, further comprising at least one of a polymer, biopolymer, nanoparticle, or detection material.

62. The composition of claim 61, wherein the detection material includes at least one electronic identification device.

63. The composition of claim 62, wherein the at least one electronic identification device includes at least one radio frequency identification device.

64. The composition of claim 61, wherein the detection material includes at least one radioactive element.

65. The composition of claim 64, wherein the at least one radioactive element includes one or more of ³²P, ³⁵S, ¹³C, ¹³¹I, ¹⁹¹Ir, ¹⁹²Ir, ¹⁹³Ir, ²⁰¹Tl, or ³H.

66. The composition of claim 61, wherein the detection material includes at least one calorimetric substance.

67. The composition of claim 66, wherein the at least one calorimetric substance includes one or more of an inorganic, organic, biological, natural, artificial, or synthetic substance.

68. The composition of claim 66, wherein the at least one calorimetric substance includes one or more of a dye, pigment or light-emitting substance.

69. The composition of claim 68, wherein the light-emitting substance includes at least one of a fluorescent substance, phosphorescent substance, or quantum dot.

70. The composition of claim 66, wherein the at least one colorimetric substance is biocompatible.

71. The composition of claim 61, wherein the detection material includes at least one of a diamagnetic particle, ferromagnetic particle, paramagnetic particle, super paramagnetic contrast agent, or other magnetic particle.

73. The composition of claim 40, wherein the one or more frozen particles include a plurality of frozen particles that are approximately uniform with regard to size, shape, weight, or density.

74. The composition of claim 40, formulated to be administered by high velocity impact.

76. The composition of claim 40, further comprising at least one pharmaceutically-acceptable carrier or excipient.

77. The composition of claim 40, wherein the one or more explosive materials include at least one of a high explosive or a low explosive.

78. The composition of claim 40, wherein the one or more explosive materials include at least one of carbon dioxide, nitroglycerine, or a reactive metal.

42. (canceled)

48-51. -51. (canceled)

54-56. -56. (canceled)

59-60. -60. (canceled)

72. (canceled)

75. (canceled)

79-162. -162. (canceled)