Compositions and methods for administering compartmentalized frozen particles

• US 20100111847A1
• Filed: 03/27/2009
• Published: 05/06/2010
• Est. Priority Date: 10/31/2008
• Status: Active Grant

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: Searete LLC (Intellectual Ventures LLC)
• Inventors: Myhrvold, Nathan P., Boyden, Edward S., Wood, Lowell L. JR., Hyde, Roderick A., Sweeney, Elizabeth A., Leuthardt, Eric C., Cook, Daniel B.
• Granted Patent: US 8,545,857 B2
• Time in Patent Office: Days
• US Class Current: 424/1.290
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/00 Medicinal preparations containing organic active ingredients
• CPC Class Codes: A61K 31/10 Sulfides; Sulfoxides; Sulfones
• CPC Class Codes: A61K 31/337 having four-membered rings, e.g. taxol
• CPC Class Codes: A61K 31/70 Carbohydrates; Sugars; Derivatives thereof sorbitol A61K31/047
• CPC Class Codes: A61K 31/7088 Compounds having three or more nucleosides or nucleotides
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61K 39/00 Medicinal preparations containing antigens or antibodies materials for immunoassay G01N33/53
• CPC Class Codes: A61K 41/0004 Homeopathy; Vitalisation; Resonance; Dynamisation, e.g. esoteric applications; Oxygenation of blood
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 49/1818 particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
• CPC Class Codes: A61K 51/12 characterised by a special physical form, e.g. emulsion, microcapsules, liposomes , characterized by a special physical form, e.g. emulsions, dispersions, microcapsules liposomes A61K51/1234
• CPC Class Codes: A61K 51/1244 microparticles or nanoparticles, e.g. polymeric nanoparticles
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61K 9/0021 Intradermal administration, e.g. through microneedle arrays, needleless injectors mechanical aspects A61M
• CPC Class Codes: A61K 9/007 Pulmonary tract; Aromatherapy
• CPC Class Codes: A61K 9/08 Solutions composition of solutions A61K47/00
• CPC Class Codes: A61K 9/1611 Inorganic compounds
• CPC Class Codes: A61K 9/1641 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
• CPC Class Codes: A61K 9/1664 Compounds of unknown constitution, e.g. material from plants or animals oils, fats, waxes, shellac A61K9/1617
• CPC Class Codes: A61K 9/1688 : resulting in pure drug agglomerate optionally containing up to 5% of excipient
• CPC Class Codes: A61K 9/19 : lyophilised , i.e. freeze-dried, solutions or dispersions lyophilised products with subsequent particle size reduction A61K9/14; granules or pellets made by lyphilisation A61K9/1682; solid oral dosage forms made by lyophilisation A61K9/2095; lyophilisation additives A61K47/00
• CPC Class Codes: B33Y 80/00 : Products made by additive manufacturing

Abstract

Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.

Claims

1. A frozen particle composition, comprising:

a non-hydrogen oxide frozen solvent particle defining at least one cavity; and

the at least one cavity containing at least one agent.

2. The frozen particle composition of claim 1, wherein the non-hydrogen oxide frozen solvent particle includes a frozen particle of at least one of acetone, ethyl acetate, dimethyl sulfoxide, dimethyl formamide, dioxane, tetrahydrofuran, acetronitrile, acetic acid, n-butanol, isopropanol, n-propanol, hexamethylphosphorotriamide, perfluorohydrocarbon, methanol, ethanol, tert-butyl alcohol, formic acid, hydrogen fluoride, ammonia, benzene, carbon tetrachloride, acetonitrile, hexane, dichloromethane, methylene chloride, carboxylic acid, saline, standard saline citrate, methane, toluene, chloroform, or diethyl ether.

3. The frozen particle composition of claim 1, wherein the non-hydrogen oxide frozen solvent particle further comprises at least one of polyethylene glycol, Ringer'"'"'s solution, lactated Ringer'"'"'s solution, Hartmann'"'"'s solution, acetated Ringer'"'"'s solution, phosphate buffered solution, TRIS-buffered saline solution, Hank'"'"'s balanced salt solution, Earle'"'"'s balanced salt solution, HEPES-buffered saline, dextrose, or glucose.

4. The frozen particle composition of claim 1, wherein at least one cavity is configured to physically or chemically separate the at least one agent from at least one other cavity of the frozen solvent particle.

11. The frozen particle composition of claim 1, wherein the at least one cavity is an inner core cavity of at least one frozen solvent particle.

14. The frozen particle composition of claim 1, wherein the at least one cavity has a higher concentration of the at least one agent than any other cavity.

18. The frozen particle composition of claim 1, wherein the at least one cavity includes one or more layers of at least one agent.

24. The frozen particle composition of claim 1, wherein the at least one agent includes one or more of a pro-drug or precursor compound.

25. The frozen particle composition of claim 1, wherein the at least one agent includes one or more time-release or extended-release formulations.

44. The frozen particle composition of claim 1, further comprising at least one of a nanoparticle, detection material, sensor, micro-syringe, or circuit.

45. The frozen particle composition of claim 44, wherein the detection material is intermixed with the at least one frozen particle composition.

46. The frozen particle composition of claim 44, wherein the detection material is located in the at least one frozen particle composition.

47. The frozen particle composition of claim 44, wherein the detection material is located in at least one cavity of at least one frozen particle composition.

48. The frozen particle composition of claim 44, wherein the detection material includes at least one electronic identification device.

49. The frozen particle composition of claim 48, wherein the at least one electronic identification device includes at least one radio frequency identification device.

50. The frozen particle composition of claim 44, wherein the detection material includes at least one radioactive element.

51. The frozen particle composition of claim 50, wherein the at least one radioactive element includes one or more of ³²P, ³⁵S, ¹³C, ¹³¹I, ¹⁹¹Ir, 192Ir, ¹⁹³Ir, or ³H.

52. The frozen particle composition of claim 44, wherein the detection material includes at least one luminescent, calorimetric or odorous substance.

53. The frozen particle composition of claim 52, wherein the at least one colorimetric substance includes one or more of an inorganic, organic, biological, natural, artificial, or synthetic substance.

54. The frozen particle composition of claim 44, wherein the at least one detection material includes one or more of a dye, pigment, luminescent substance, fluorescent substance, or phosphorescent substance.

55. The frozen particle composition of claim 44, wherein the detection material includes at least one of a diamagnetic particle, ferromagnetic particle, paramagnetic particle, super paramagnetic contrast agent, or other magnetic particle.

5-10. -10. (canceled)

12-13. -13. (canceled)

15-17. -17. (canceled)

19-23. -23. (canceled)

26-43. -43. (canceled)

56-62. -62. (canceled)

63. A method of providing at least one agent to at least one biological tissue of a subject, comprising:

administering at least one frozen particle composition to at least one biological tissue, wherein the at least one frozen particle composition includes one or more non-hydrogen oxide frozen solvent particles that include at least one cavity; and

the at least one cavity containing at least one agent.

64. The method of claim 63, wherein the one or more non-hydrogen-oxide frozen solvent particles include at least one of acetone, ethyl acetate, dimethyl sulfoxide, dimethyl formamide, dioxane, tetrahydrofuran, acetronitrile, acetic acid, n-butanol, isopropanol, n-propanol, hexamethylphosphorotriamide, perfluorohydrocarbon, methanol, ethanol, tert-butyl alcohol, formic acid, hydrogen fluoride, ammonia, benzene, carbon tetrachloride, acetonitrile, hexane, dichloromethane, methylene chloride, carboxylic acid, saline, standard saline citrate, methane, toluene, chloroform, or diethyl ether.

65. The method of claim 63, wherein the one or more non-hydrogen oxide frozen solvent particles further comprise at least one of polyethylene glycol, Ringer'"'"'s solution, lactated Ringer'"'"'s solution, Hartmann'"'"'s solution, acetated Ringer'"'"'s solution, phosphate buffered solution, TRIS-buffered saline solution, Hank'"'"'s balanced salt solution, Earle'"'"'s balanced salt solution, HEPES-buffered saline, dextrose, or glucose.

70. The method of claim 63, wherein administering the at least one frozen particle composition to at least one biological tissue includes propelling, ejecting, or accelerating the at least one frozen particle composition toward the at least one biological tissue at a predetermined angle, a predetermined velocity, a predetermined rate of administration, a predetermined depth, a predetermined location, a predetermined time sequence, or a predetermined spatial pattern.

71. The method of claim 63, further comprising varying the rate, velocity, or angle at which the at least one frozen particle composition is administered to the at least one biological tissue.

72. The method of claim 63, wherein administering at least one frozen particle composition to the at least one biological tissue includes propelling, ejecting, or accelerating a plurality of frozen particle compositions toward the at least one biological tissue.

73. The method of claim 72, wherein two or more frozen particle compositions of the plurality of frozen particle compositions include one or more similar agents.

77. The method of claim 63, wherein the at least one biological tissue is located in at least one of in situ, in vitro, in vivo, in utero, in planta, in silico, or ex vivo.

83. The method of claim 63, wherein the at least one biological tissue includes at least one cell mass.

85. The method of claim 83, wherein the at least one cell mass includes at least one benign or malignant tumor.

87. The method of claim 83, wherein the at least one biological tissue includes one or more of a stalk, stem, leaf, root, plant, or tendril.

88. The method of claim 63, further comprising administering to the at least one biological tissue at least one of a nanoparticle, detection material, sensor, circuit, or micro-syringe.

92. The method of claim 88, wherein the detection material includes at least one electronic identification device.

93. The method of claim 92, wherein the at least one electronic identification device includes at least one radio frequency identification device.

96. The method of claim 88, wherein the detection material includes at least one radioactive, luminescent, calorimetric or odorous substance.

66-69. -69. (canceled)

74-76. -76. (canceled)

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84. (canceled)

86. (canceled)

89-91. -91. (canceled)

94-95. -95. (canceled)

97-105. -105. (canceled)

106. A method of vaccinating a subject, comprising:

administering to at least one biological tissue of a subject at least one frozen particle composition;

wherein the at least one frozen particle composition includes one or more non-hydrogen oxide frozen solvent particles defining at least one cavity; and

the at least one cavity containing at least one vaccine.

107. The method of claim 106, wherein the one or more non-hydrogen oxide frozen solvent particles include at least one of acetone, ethyl acetate, dimethyl sulfoxide, dimethyl formamide, dioxane, tetrahydrofuran, acetronitrile, acetic acid, n-butanol, isopropanol, n-propanol, hexamethylphosphorotriamide, perfluorohydrocarbon, methanol, ethanol, tert-butyl alcohol, formic acid, hydrogen fluoride, ammonia, benzene, carbon tetrachloride, acetonitrile, hexane, dichloromethane, methylene chloride, carboxylic acid, saline, standard saline citrate, methane, toluene, chloroform, or diethyl ether.

108. The method of claim 106, wherein the one or more non-hydrogen oxide frozen solvent particles further comprise at least one of polyethylene glycol, Ringer'"'"'s solution, lactated Ringer'"'"'s solution, Hartmann'"'"'s solution, acetated Ringer'"'"'s solution, phosphate buffered solution, TRIS-buffered saline solution, Hank'"'"'s balanced salt solution, Earle'"'"'s balanced salt solution, HEPES-buffered saline, dextrose, or glucose.

110. The method of claim 106, wherein the at least one vaccine includes at least one prophylactic or therapeutic vaccine.

112. The method of claim 106, wherein the at least one frozen particle composition further comprises at least one adjuvant.

114. The method of claim 112, wherein the at least one adjuvant and the at least one vaccine are located in multiple cavities of the one or more frozen solvent particles.

116. The method of claim 106, wherein administering the at least one frozen particle composition to at least one biological tissue includes propelling, ejecting, or accelerating the at least one frozen particle composition toward the at least one biological tissue at a predetermined angle, a predetermined velocity, or a predetermined rate of administration.

109. (canceled)

111. (canceled)

113. (canceled)

115. (canceled)

117-145. -145. (canceled)

146. A frozen particle composition, comprising:

a non-hydrogen oxide frozen solvent particle defining at least one cavity configured for holding at least one agent.

147. The frozen particle composition of claim 146, wherein the frozen solvent particle includes at least one inlet port in fluid communication with the at least one cavity.

148. The frozen particle composition of claim 146, wherein the frozen solvent particle includes at least one status indicator.

149. The frozen particle composition of claim 148, wherein the at least one status indicator indicates one or more of:

content of the at least one cavity, amount of cavity space occupied, or amount of cavity space available.

150. The frozen particle composition of claim 148, wherein the at least one status indicator includes at least one of a sensor, a magnet, a calorimetric substance, or a physical measuring device.

160. The frozen particle composition of claim 146, wherein the at least one cavity is located at an inner core region of the frozen solvent particle.

161. The frozen particle composition of claim 146, wherein the at least one cavity is located at a superficial or exterior region of the frozen solvent particle.

151-159. -159. (canceled)

162-187. -187. (canceled)