Compositions and methods for administering compartmentalized frozen particles

• US 20100111849A1
• Filed: 03/27/2009
• Published: 05/06/2010
• Est. Priority Date: 10/31/2008
• Status: Active Grant

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: Searete LLC (Intellectual Ventures LLC)
• Inventors: Myhrvold, Nathan P., Boyden, Edward S., Wood, Lowell L. JR., Hyde, Roderick A., Sweeney, Elizabeth A., Leuthardt, Eric C., Cook, Daniel B.
• Granted Patent: US 8,551,506 B2
• Time in Patent Office: Days
• US Class Current: 424/1.290
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/00 Medicinal preparations containing organic active ingredients
• CPC Class Codes: A61K 31/337 having four-membered rings, e.g. taxol
• CPC Class Codes: A61K 31/70 Carbohydrates; Sugars; Derivatives thereof sorbitol A61K31/047
• CPC Class Codes: A61K 31/7088 Compounds having three or more nucleosides or nucleotides
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61K 39/00 Medicinal preparations containing antigens or antibodies materials for immunoassay G01N33/53
• CPC Class Codes: A61K 41/0004 Homeopathy; Vitalisation; Resonance; Dynamisation, e.g. esoteric applications; Oxygenation of blood
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61K 9/12 Aerosols; Foams A61K9/0043, A61K9/0056, A61K9/006, A61K9/0073 take precedence; spray-films A61K9/7015
• CPC Class Codes: A61K 9/1611 Inorganic compounds
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: B33Y 80/00 Products made by additive manufacturing

Abstract

Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.

Claims

1. A frozen particle composition, comprising:

a frozen hydrogen oxide particle defining at least one cavity;

the at least one cavity containing at least one agent; and

wherein the frozen hydrogen oxide particle is in one or more phases including at least one of amorphous solid water, low density amorphous ice, high density amorphous ice, very high density amorphous ice, clathrate ice, hyperquenched glassy water, ice Ic, ice II, ice III, ice IV, ice V, ice VI, ice VII, ice VIII, ice IX, ice X, ice XI, ice XII, ice XIII, ice XIV, or ice XV.

2. The frozen particle composition of claim 1, wherein at least one cavity is configured to physically or chemically separate the at least one agent from at least one other cavity of the frozen hydrogen oxide particle.

3. The frozen particle composition of claim 1, wherein at least one cavity is configured to physically or chemically separate from at least one other cavity of the frozen hydrogen oxide particle during administration.

9. The frozen particle composition of claim 1, wherein the at least one cavity is an inner core cavity of at least one frozen hydrogen oxide particle.

10. The frozen particle composition of claim 1, wherein the at least one cavity includes an inner core cavity and wherein the at least one agent is at least one of a liquid or gas.

12. The frozen particle composition of claim 1, wherein the at least one cavity has a higher concentration of the at least one agent than any other cavity.

13. The frozen particle composition of claim 12, wherein the at least one cavity includes a graduated concentration of the at least one agent.

14. The frozen particle composition of claim 1, wherein the at least one cavity includes varying levels of the at least one agent.

15. The frozen particle composition of claim 1, wherein the at least one agent is fractionated.

16. The frozen particle composition of claim 1, wherein the at least one cavity includes one or more layers of at least one agent.

18. The frozen particle composition of claim 1, further comprising two or more cavities, each containing at least one different agent.

22. The frozen particle composition of claim 1, wherein the at least one agent includes one or more of a pro-drug or precursor compound.

23. The frozen particle composition of claim 1, wherein the at least one agent includes one or more time-release or extended-release formulations.

24. The frozen particle composition of claim 1, wherein the at least one agent includes an activatable agent.

38. The frozen particle composition of claim 1, wherein the at least one agent includes one or more of an adhesive agent, reinforcement agent, abrasive, therapeutic agent, biological remodeling agent, or explosive material.

39. The frozen particle composition of claim 1, further comprising a plurality of frozen particles that are approximately uniform in size, shape, weight, or density.

41. The frozen particle composition of claim 1, further comprising at least one pharmaceutically-acceptable carrier or excipient.

42. The frozen particle composition of claim 1, further comprising at least one of a nanoparticle, detection material, sensor, micro-syringe, or circuit.

43. The frozen particle composition of claim 42, wherein the detection material is intermixed with the at least one frozen particle composition.

44. The frozen particle composition of claim 42, wherein the detection material is located in the at least one frozen particle composition.

45. The frozen particle composition of claim 42, wherein the detection material is located in at least one cavity of at least one frozen particle composition.

46. The frozen particle composition of claim 42, wherein the detection material includes at least one electronic identification device.

47. The frozen particle composition of claim 46, wherein the at least one electronic identification device includes at least one radio frequency identification device.

48. The frozen particle composition of claim 42, wherein the detection material includes at least one radioactive element.

49. The frozen particle composition of claim 48, wherein the at least one radioactive element includes one or more of ³²P, ³⁵S, ¹³C, ¹³¹I, ¹⁹¹Ir, ¹⁹²Ir, ¹⁹³Ir, or ³H.

50. The frozen particle composition of claim 42, wherein the detection material includes at least one luminescent, colorimetric or odorous substance.

51. The frozen particle composition of claim 50, wherein the at least one calorimetric substance includes one or more of an inorganic, organic, biological, natural, artificial, or synthetic substance.

52. The frozen particle composition of claim 42, wherein the at least one detection material includes one or more of a dye, pigment, luminescent substance, fluorescent substance, or phosphorescent substance.

53. The frozen particle composition of claim 42, wherein the detection material includes at least one of a diamagnetic particle, ferromagnetic particle, paramagnetic particle, super paramagnetic contrast agent, or other magnetic particle.

54. The frozen particle composition of claim 1, wherein the at least one agent includes at least one nontoxic, biocompatible, bioresorbable, or biodegradable agent.

4-8. -8. (canceled)

11. (canceled)

17. (canceled)

19-21. -21. (canceled)

25-37. -37. (canceled)

40. (canceled)

55-63. -63. (canceled)

64. A method of providing at least one agent to at least one biological tissue of a subject, comprising:

administering at least one frozen particle composition to at least one biological tissue, wherein the at least one frozen particle composition includes one or more frozen hydrogen oxide particles defining at least one cavity;

the at least one cavity containing at least one agent; and

wherein the one or more frozen hydrogen oxide particles are in one or more phases including at least one of amorphous solid water, low density amorphous ice, high density amorphous ice, very high density amorphous ice, clathrate ice, hyperquenched glassy water, ice Ic, ice II, ice III, ice IV, ice V, ice VI, ice VII, ice VIII, ice IX, ice X, ice XI, ice XII, ice XIII, ice XIV, or ice XV.

69. The method of claim 64, wherein administering the at least one frozen particle composition to at least one biological tissue includes propelling, ejecting, or accelerating the at least one frozen particle composition toward the at least one biological tissue at a predetermined angle, a predetermined velocity, a predetermined rate of administration, a predetermined depth, a predetermined location, a predetermined time sequence, or a predetermined spatial pattern.

70. The method of claim 64, further comprising varying the rate, velocity, or angle at which the at least one frozen particle composition is administered to the at least one biological tissue.

87. The method of claim 64, further comprising administering to the at least one biological tissue at least one of a nanoparticle, detection material, sensor, circuit, or micro-syringe.

88. The method of claim 87, wherein the detection material is intermixed with the at least one frozen particle composition.

89. The method of claim 87, wherein the detection material is located in the at least one frozen particle composition.

90. The method of claim 87, wherein the detection material is located in the at least one cavity of at least one frozen particle.

65-68. -68. (canceled)

71-86. -86. (canceled)

91-107. -107. (canceled)

108. A method of vaccinating a subject, comprising:

administering to at least one biological tissue of a subject at least one frozen particle composition;

wherein the at least one frozen particle composition includes one or more frozen hydrogen oxide particles defining at least one cavity;

the at least one cavity containing at least one vaccine; and

wherein the one or more frozen hydrogen oxide particles are in one or more phases including at least one of amorphous solid water, low density amorphous ice, high density amorphous ice, very high density amorphous ice, clathrate ice, hyperquenched glassy water, ice Ic, ice II, ice III, ice IV, ice V, ice VI, ice VII, ice VIII, ice IX, ice X, ice XI, ice XII, ice XIII, ice XIV, or ice XV.

110. The method of claim 108, wherein the at least one vaccine includes at least one prophylactic or therapeutic vaccine.

112. The method of claim 108, wherein the at least one frozen particle composition further comprises at least one adjuvant.

113. The method of claim 112, wherein the at least one adjuvant and the at least one vaccine are located in at least one of the same or different cavities of the one or more frozen particles.

114. The method of claim 113, wherein the at least one adjuvant and the at least one vaccine are located in multiple cavities of the one or more frozen particles.

117. The method of claim 108, wherein the at least one vaccine is configured for activation by administration of the at least one frozen particle composition.

109. (canceled)

111. (canceled)

115-116. -116. (canceled)

118-145. -145. (canceled)

146. A frozen particle composition, comprising:

a frozen hydrogen oxide particle defining at least one cavity configured for holding at least one agent;

wherein the frozen hydrogen oxide particle is in one or more phases including at least one of amorphous solid water, low density amorphous ice, high density amorphous ice, very high density amorphous ice, clatllrate ice, hyperquenched glassy water, ice Ic, ice II, ice III, ice IV, ice V, ice VI, ice VII, ice VIII, ice IX, ice X, ice XI, ice XII, ice XIII, ice XIV, or ice XV.

147. The frozen particle composition of claim 146, wherein the frozen hydrogen oxide particle includes at least one inlet port in fluid communication with the at least one cavity.

148. The frozen particle composition of claim 146, wherein frozen hydrogen oxide particle includes at least one status indicator.

149. The frozen particle composition of claim 148, wherein the at least one status indicator indicates one or more of:

content of the at least one cavity, amount of cavity space occupied, or amount of cavity space available.

150. The frozen particle composition of claim 148, wherein the at least one status indicator includes at least one of a sensor, a magnet, a calorimetric substance, or a physical measuring device.

160. The frozen particle composition of claim 146, wherein the at least one cavity is located at an inner core region of the one or more frozen hydrogen oxide particles.

161. The frozen particle composition of claim 146, wherein the at least one cavity is located at a superficial or exterior region of the one or more frozen hydrogen oxide particles.

151-159. -159. (canceled)

162-187. -187. (canceled)