Frozen compositions and methods for piercing a substrate

• US 20100111854A1
• Filed: 09/15/2009
• Published: 05/06/2010
• Est. Priority Date: 10/31/2008
• Status: Active Grant

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: Searete LLC A Limited Liability Corporation of The State of Delaware
• Inventors: Myhrvold, Nathan P., Boyden, Edward S., Wood, Lowell L. JR., Hyde, Roderick A., Sweeney, Elizabeth A., Leuthardt, Eric C., Cook, Daniel B.
• Granted Patent: US 9,040,087 B2
• Time in Patent Office: Days
• US Class Current: 424/1.490
• CPC Class Codes: A61K 2039/505 comprising antibodies
• CPC Class Codes: A61K 2039/54 characterised by the route of administration
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/00 Medicinal preparations containing organic active ingredients
• CPC Class Codes: A61K 31/337 having four-membered rings, e.g. taxol
• CPC Class Codes: A61K 31/505 Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
• CPC Class Codes: A61K 31/519 ortho- or peri-condensed with heterocyclic rings
• CPC Class Codes: A61K 31/59 Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
• CPC Class Codes: A61K 31/70 Carbohydrates; Sugars; Derivatives thereof sorbitol A61K31/047
• CPC Class Codes: A61K 31/7088 Compounds having three or more nucleosides or nucleotides
• CPC Class Codes: A61K 31/74 Synthetic polymeric materials
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61K 38/38 Albumins
• CPC Class Codes: A61K 38/4833 Thrombin (3.4.21.5)
• CPC Class Codes: A61K 38/4886 Metalloendopeptidases (3.4.24), e.g. collagenase
• CPC Class Codes: A61K 39/00 Medicinal preparations containing antigens or antibodies materials for immunoassay G01N33/53
• CPC Class Codes: A61K 39/12 Viral antigens
• CPC Class Codes: A61K 39/145 Orthomyxoviridae, e.g. influenza virus
• CPC Class Codes: A61K 41/0004 Homeopathy; Vitalisation; Resonance; Dynamisation, e.g. esoteric applications; Oxygenation of blood
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 9/0019 : Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61K 9/0021 : Intradermal administration, e.g. through microneedle arrays, needleless injectors mechanical aspects A61M
• CPC Class Codes: A61K 9/007 : Pulmonary tract; Aromatherapy
• CPC Class Codes: A61K 9/08 : Solutions composition of solutions A61K47/00
• CPC Class Codes: A61K 9/12 : Aerosols; Foams A61K9/0043, A61K9/0056, A61K9/006, A61K9/0073 take precedence; spray-films A61K9/7015
• CPC Class Codes: A61K 9/143 : with inorganic compounds
• CPC Class Codes: A61K 9/1611 : Inorganic compounds
• CPC Class Codes: A61K 9/1641 : obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
• CPC Class Codes: A61K 9/1664 : Compounds of unknown constitution, e.g. material from plants or animals oils, fats, waxes, shellac A61K9/1617
• CPC Class Codes: A61K 9/1688 : resulting in pure drug agglomerate optionally containing up to 5% of excipient
• CPC Class Codes: A61K 9/19 : lyophilised , i.e. freeze-dried, solutions or dispersions lyophilised products with subsequent particle size reduction A61K9/14; granules or pellets made by lyphilisation A61K9/1682; solid oral dosage forms made by lyophilisation A61K9/2095; lyophilisation additives A61K47/00
• CPC Class Codes: A61K 9/209 : containing drug in at least two layers or in the core and in at least one outer layer
• CPC Class Codes: A61K 9/2095 : Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing mechanical aspects A61J3/00
• CPC Class Codes: A61K 9/2866 : Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
• CPC Class Codes: A61M 2037/0023 : Drug applicators using microneedles
• CPC Class Codes: A61M 2037/003 : having a lumen
• CPC Class Codes: A61M 2205/02 : characterised by a particular materials
• CPC Class Codes: A61M 37/0015 : by using microneedles
• CPC Class Codes: A61P 17/02 : for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 31/16 : for influenza or rhinoviruses
• CPC Class Codes: A61P 35/00 : Antineoplastic agents
• CPC Class Codes: B33Y 80/00 : Products made by additive manufacturing
• CPC Class Codes: C07K 16/22 : against growth factors ; against growth regulators
• CPC Class Codes: C07K 16/283 : against Fc-receptors, e.g. CD16, CD32, CD64 CD23 C07K16/2851
• CPC Class Codes: C07K 16/2842 : against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
• CPC Class Codes: C07K 16/2878 : against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
• CPC Class Codes: C07K 16/30 : from tumour cells
• CPC Class Codes: C12N 2760/16034 : Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
• CPC Class Codes: G16H 20/10 : relating to drugs or medications, e.g. for ensuring correct administration to patients
• CPC Class Codes: G16H 30/40 : for processing medical images, e.g. editing
• CPC Class Codes: G16H 50/20 : for computer-aided diagnosis, e.g. based on medical expert systems
• CPC Class Codes: G16H 50/50 : for simulation or modelling of medical disorders
• CPC Class Codes: Y02A 50/30 : Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
• CPC Class Codes: Y02A 90/10 : Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
• CPC Class Codes: Y10T 83/222 : With receptacle or support for cut product

Abstract

Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.

Claims

1. A frozen piercing implement, comprising:

at least one sterile frozen solution, the solution including at least one agent;

wherein the frozen piercing implement is configured for piercing at least part of at least one substrate.

3. The frozen piercing implement of claim 1, wherein the frozen piercing implement has at least one major dimension of approximately one centimeter or less, approximately one millimeter or less, approximately one micrometer or less, approximately one nanometer, or any value therebetween;

and

8. The frozen piercing implement of claim 1, wherein the at least one agent includes at least one of a therapeutic agent, explosive material, reinforcement agent, adhesive agent, biological remodeling agent, or abrasive.

18. The frozen particle composition of claim 1, wherein the at least one agent includes one or more of a prodrug or precursor compound.

20. The frozen piercing implement of claim 1, wherein the frozen piercing implement includes at least one cavity.

25. The frozen piercing implement of claim 1, further comprising at least one detection material.

26. The frozen piercing implement of claim 25, wherein the at least one detection material includes at least one of a contrast agent, sensor, or electronic identification device.

27. The frozen piercing implement of claim 26, wherein the at least one electronic identification device includes at least one radio frequency identification device.

28. The frozen piercing implement of claim 25, wherein the at least one detection material includes at least one temperature-sensitive substance.

29. The frozen piercing implement of claim 25, wherein the at least one detection material includes at least one of a radioactive, luminescent, colorimetric or odorous substance.

30. The frozen piercing implement of claim 29, wherein the at least one radioactive, luminescent, colorimetric or odorous substance includes at least one temperature-sensitive substance.

32. The frozen piercing implement of claim 1, wherein the at least one frozen piercing implement includes at least one channel.

41. The frozen piercing implement of claim 32, wherein at least one surface of the at least one channel is substantially hydrophobic.

42. The frozen piercing implement of claim 32, wherein at least one surface of the at least one channel is substantially hydrophilic.

45. The frozen piercing implement of claim 1, wherein the frozen piercing implement approximates the shape of at least one of a sphere, bullet, flechette, cone, frustrum, needle, arrow, spear, diamond, pyramid, cylinder, mine ball, shuttlecock, spiral, bell, pear, crystal, cube, spheroid, tetrahedron, crescent, possesses a high aspect ratio shape, or any combination thereof.

65. The frozen piercing implement of claim 1, further including at least one non-frozen implement holding device.

66. The frozen piercing implement of claim 65, wherein the at least one non-frozen implement holding device includes at least one handle, robotic arm, or surgical device.

70. The frozen piercing implement of claim 1, wherein the frozen piercing implement includes at least one substantially tapered end.

82. The frozen piercing implement of claim 1, wherein the frozen piercing implement includes at least one port.

83. The frozen piercing implement of claim 82, wherein the at least one port includes at least one side port.

84. The frozen piercing implement of claim 82, wherein the at least one port includes at least one end port.

85. The frozen piercing implement of claim 82, wherein the at least one port includes at least one inlet port or outlet port.

86. The frozen piercing implement of claim 85, wherein the at least one inlet port or outlet port is in fluid communication with at least one channel.

96. The frozen piercing implement of claim 1, wherein the at least one frozen piercing implement includes at least one sensor.

97. The frozen piercing implement of claim 96, wherein the at least one sensor includes at least one sensor configured for detecting at least one of a biochemical, electrical, optical, functional, physical, chemical, biological, or structural characteristic of the at least one material.

98. The frozen piercing implement of claim 1, wherein the at least one frozen piercing implement is configured to extract at least one material from the at least one substrate.

109. The frozen piercing implement of claim 1, wherein the frozen piercing implement is substantially in the form of at least one blade.

111. The frozen piercing implement of claim 1, configured as a tweezers, fork, scriber, graver, spade, screw, needle or pin.

112. The frozen piercing implement of claim 111, wherein the needle or pin include at least one macroneedle, macropin, microneedle, micropin, nanoneedle, or nanopin.

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116. A method of administering at least one frozen piercing implement to at least one substrate, comprising:

contacting at least one substrate with at least one frozen piercing implement, wherein the at least one frozen piercing implement includes at least one sterile frozen solution, the solution including at least one agent.

123. The method of claim 116, wherein the at least one agent includes one or more components that are inactive.

124. The method of claim 123, wherein the one or more components are configured to be activated by administration.

126. The method of claim 116, wherein the at least one substrate includes one or more of a cell, tissue, organ, structure, device, or food product.

127. The method of claim 126, wherein the structure includes one or more of a prosthesis, cell scaffold, or tissue scaffold.

128. The method of claim 126, wherein the device includes at least one mechanical or electrical device.

129. The method of claim 116, wherein the substrate includes at least a portion of which is naturally, artificially, or synthetically derived.

130. The method of claim 116, wherein the substrate includes at least a portion of which is genetically altered.

131. The method of claim 116, wherein the at least one substrate is located in at least one of in situ, in vitro, in vivo, in utero, in planta, in silico, or ex vivo.

150. The method of claim 116, wherein administering the at least one frozen piercing implement to at least one substrate includes accelerating, propelling, pushing, pulling, or ejecting the at least one frozen piercing implement toward the at least one substrate.

154. The method of claim 116, further comprising varying the rate, velocity, force, or angle at which the at least one frozen piercing implement is administered to the at least one substrate.

155. The method of claim 116, wherein administering the at least one frozen piercing implement to at least one substrate includes propelling, ejecting, pushing, pulling, drilling, or accelerating a plurality of frozen piercing implements toward the at least one substrate.

157. The method of claim 155, wherein two or more of the plurality of frozen piercing implements each includes at least one agent that physically or chemically bind upon administration.

160. The method of claim 116, further comprising administering to the at least one substrate at least one article including an optical, photonic, or electronic article.

161. The method of claim 160, wherein the at least one article is configured to communicate with at least one computer system.

162. The method of claim 160, wherein the at least one article is configured to monitor at least one characteristic of the at least one substrate.

163. The method of claim 160, wherein the at least one article is intermixed with the at least one frozen piercing implement.

164. The method of claim 160, wherein the at least one article is located in the at least one frozen piercing implement.

165. The method of claim 160, wherein the at least one article includes at least one electronic identification device.

167. The method of claim 160, wherein the at least one article includes at least one radioactive, luminescent, colorimetric or odorous substance.

171. The method of claim 116, wherein contacting at least one substrate includes at least one of cutting, stitching, cauterizing, freezing, perforating, penetrating, ablating, or abrading at least a part of the surface of the at least one substrate.

173. The method of claim 116, further comprising sensing or extracting at least one material from the at least one substrate.

178. The method of claim 116, further comprising withdrawing the at least one frozen piercing implement from the at least one substrate.

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