Compositions and methods for biological remodeling with frozen particle compositions

• US 20100111938A1
• Filed: 03/31/2009
• Published: 05/06/2010
• Est. Priority Date: 10/31/2008
• Status: Active Grant

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: Searete LLC (Intellectual Ventures LLC)
• Inventors: Myhrvold, Nathan P., Boyden, Edward S., Wood, Lowell L. JR., Hyde, Roderick A., Sweeney, Elizabeth A., Leuthardt, Eric C., Cook, Daniel B.
• Granted Patent: US 8,603,495 B2
• Time in Patent Office: Days
• US Class Current: 424/133.100
• CPC Class Codes: A61K 2039/505 comprising antibodies
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: B33Y 80/00 Products made by additive manufacturing
• CPC Class Codes: C07K 16/2824 against CD58
• CPC Class Codes: C07K 16/283 against Fc-receptors, e.g. CD16, CD32, CD64 CD23 C07K16/2851
• CPC Class Codes: C07K 16/2842 against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
• CPC Class Codes: C07K 16/2878 against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
• CPC Class Codes: C07K 16/30 from tumour cells

Abstract

Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.

Claims

1. A frozen particle composition, comprising:

one or more frozen solution particles that include at least one biological remodeling agent;

wherein the one or more frozen solution particles have at least one major dimension of approximately one centimeter or less, approximately one millimeter or less, approximately one micrometer or less, approximately one nanometer or less, or any value therebetween.

3. The frozen particle composition of claim 1, wherein the at least one major dimension includes at least one of the radius, diameter, length, width, height, or perimeter.

4. The frozen particle composition of claim 1, wherein the at least one biological remodeling agent includes one or more extracellular matrix components.

8. The frozen particle composition of claim 1, wherein the at least one biological remodeling agent is configured to promote at least partial construction or at least partial reconstruction of at least one biological tissue.

9. The frozen particle composition of claim 1, wherein the at least one biological remodeling agent is configured to provide at least one mechanical structure to the at least one biological tissue.

10. The frozen particle composition of claim 1, wherein the at least one biological remodeling agent is configured to provide oxygenation, nutrition, or other nourishment to the at least one biological tissue.

12. The frozen particle composition of claim 1, wherein the at least one biological remodeling agent is located in at least one cavity of the one or more frozen particle compositions.

28. The frozen particle composition of claim 1, wherein the at least one biological remodeling agent includes one or more of a blood cell, chondrocyte, endothelial cell, hepatocyte, keratinocyte, myocyte, osteoblast, osteoclast, osteocyte, mesenchymal cell, stem cell, progenitor cell, or fibroblast.

29. The frozen particle composition of claim 1, wherein the at least one biological remodeling agent includes one or more of:

calcium phosphate, albumin, cytokine, pegylated cytokine, bone, cartilage, globulin, fibrin, thrombin, glutaraldehyde-crosslinked pericardium, hide powder, hyaluronic acid, hydroxylapatite, keratin, ligament, nitinol, nucleic acid polymers, polyethylene, polylethylene glycol, polyethylene glycol diacrylate, polyethylene terephthalate fiber, polyglycol, polylactate, polytetrafluoroethylene, polylactic acid, polyglycolic acid, polycaprolactone, PURAMATRIX™

self-assembly peptide hydrogel fibers, linear aliphatic polyester, tendon, fibrinogen, hyaluronate, chitin, chitosan, methylcellulose, alginate, hyaluronic acid, agarose, cellulose, polyaldehyde gluronate, Factor XIII, Factor XII, silk, nylon, collagen, silicone, polyurethane, ceramic powder, elastin, pectin, wax, glycosaminoglycan, poly(α

-hydroxyacid), selectin, glutaraldehyde, hydrophobic non-glycosylated protein, hydrogel, peptide hydrogel, or gelatin.

30. The frozen particle composition of claim 1, wherein the at least one biological remodeling agent includes one or more of Type I collagen, Type II collagen, Type III collagen, Type VII collagen, Type X collagen, elastin fibers, or soluble elastin.

31. The frozen particle composition of claim 1, wherein the biological remodeling agent includes one or more of an angiogenic factor, growth factor, or cytokine.

44. The frozen particle composition of claim 1, further comprising at least one of a nanoparticle, detection material, sensor, micro-syringe, or circuit.

102. The method of claim 1, wherein administering one or more frozen solution particle compositions to at least one substrate includes propelling, ejecting, or accelerating the plurality of frozen particle compositions toward the at least one substrate includes at a predetermined angle, a predetermined velocity, a predetermined rate of administration, a predetermined spatial pattern, a predetermined location, a predetermined time sequence, or a predetermined depth.

103. The method of claim 102, wherein two or more of the plurality of frozen particle compositions include two or more biological remodeling agents configured to physically or chemically bind upon administration.

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56. A composition, comprising:

an ex vivo biological tissue or organ at least partially constructed or at least partially reconstructed by administering to at least one substrate one or more frozen solution particles that include at least one biological remodeling agent; and

wherein the one or more frozen solution particles have at least one major dimension of approximately one centimeter or less, approximately one millimeter or less, approximately one micrometer or less, approximately one nanometer or less, or any value therebetween.

58. The composition of claim 56, wherein the at least one substrate includes one or more of a cell, tissue, organ, structure, or device.

59. The composition of claim 56, further comprising at least one article including an optical, photonic, or electronic article.

57. (canceled)

60-63. -63. (canceled)

64. A composition, comprising:

a support means for aiding in at least partially constructing or at least partially reconstructing at least one biological tissue; and

one or more frozen particle compositions including at least one biological remodeling agent and one or more frozen solution particles;

wherein the one or more frozen solution particles have at least one major dimension of approximately one centimeter or less, approximately one millimeter or less, approximately one micrometer or less, approximately one nanometer or less, or any value therebetween.

65. The composition of claim 64, wherein the support means includes at least one substrate configured for biological tissue formation or tissue growth.

66. The composition of claim 65, wherein the support means includes one or more of a cell scaffold, a tissue scaffold, extracellular matrix, methylcellulose, agarose, a cell, a polymer, or other substrate.

69. The composition of claim 64, wherein the at least one biological tissue includes one or more of a stalk, stem, leaf, root, plant, or tendril.

67-68. -68. (canceled)

70. A method of providing at least one biological remodeling agent to at least one substrate, comprising:

administering one or more frozen solution particle compositions to at least one substrate, wherein the one or more frozen solution particle compositions include at least one biological remodeling agent; and

wherein the one or more frozen solution particle compositions have at least one major dimension of approximately one centimeter or less, approximately one millimeter or less, approximately one micrometer or less, approximately one nanometer or less, or any value therebetween.

72. The method of claim 70, wherein the at least one substrate includes one or more of a cell, tissue, organ, structure, or device.

73. The method of claim 72, wherein the structure includes one or more of a prosthesis, cell scaffold, or tissue scaffold.

74. The method of claim 72, wherein the device includes at least one mechanical or electrical device.

100. The method of claim 70, further comprising varying the rate, velocity, or angle at which the one or more frozen particle compositions are administered to at least one substrate.

104. The method of claim 70, wherein administering the one or more frozen particle compositions to at least one substrate includes contacting the at least one substrate with the one or more frozen particle compositions.

107. The method of claim 70, further comprising administering at least one article including an optical, photonic, or electronic article.

109. The method of claim 107, wherein the at least one article is configured to monitor at least one characteristic of the at least one biological tissue or organ.

112. The method of claim 70, further including administering to the at least one substrate at least one of a nanoparticle, detection material, sensor, micro-syringe, or circuit.

71. (canceled)

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122. A method of at least partially constructing or at least partially reconstructing at least one biological tissue or organ, comprising:

administering to at least one substrate one or more frozen solution particle compositions that include at least one agent, including at least one of a biological remodeling agent, adhesive agent, therapeutic agent, reinforcement agent, abrasive, or explosive material, in such a manner that the at least one agent is deposited,

wherein the at least one biological tissue or organ is located ex vivo, and

wherein the one or more frozen solution particle compositions have at least one major dimension of approximately one centimeter or less, approximately one millimeter or less, approximately one micrometer or less, approximately one nanometer or less, or any value therebetween.

127. The method of claim 122, wherein the at least one substrate includes one or more of a cell, tissue, organ, structure, or device.

128. The method of claim 127, wherein the structure includes one or more of a prosthesis, cell scaffold, or tissue scaffold.

129. The method of claim 127, wherein the device includes at least one mechanical or electrical device.

141. The method of claim 127, wherein administering the one or more frozen solution particle compositions to at least one substrate includes contacting the at least one substrate with the at least one biological remodeling agent.

150. The method of claim 127, further comprising varying the rate, velocity, or angle at which the one or more frozen solution particle compositions are administered to at least one substrate.

152. The method of claim 127, wherein the at least one substrate is located in at least one of in situ, in vitro, in vivo, in utero, in planta, in silico, or ex vivo.

160. The method of claim 127, further comprising abrading or ablating one or more surfaces of the at least one substrate prior to, during, or subsequent to the administering of the one or more frozen solution particle compositions.

169. The method of claim 127, further comprising administering at least one article including an optical, photonic, or electronic article.

171. The method of claim 169, wherein the at least one article is configured to monitor at least one characteristic of the at least one biological tissue or organ.

174. The method of claim 127, further including administering at least one of a nanoparticle, detection material, sensor, micro-syringe, or circuit.

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186. A method of at least partially constructing or at least partially reconstructing at least one biological tissue or organ, comprising:

administering one or more frozen solution particle compositions that include at least one biological remodeling agent, in such a manner that the at least one agent is deposited,

wherein the at least one biological tissue or organ is located ex vivo, and

wherein the one or more frozen solution particle compositions have at least one major dimension of approximately one centimeter or less, approximately one millimeter or less, approximately one micrometer or less, approximately one nanometer or less, or any value therebetween.