DRUG DEPOT WITH ANCHOR

• US 20100112034A1
• Filed: 10/30/2008
• Published: 05/06/2010
• Est. Priority Date: 10/30/2008
• Status: Active Grant

• Current Assignee: Warsaw Orthopedic Incorporated (Medtronic Plc)
• Original Assignee: Warsaw Orthopedic Incorporated (Medtronic Plc)
• Inventors: McKay, William F.
• Granted Patent: US 9,623,222 B2
• Time in Patent Office: Days
• US Class Current: 424/426
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50
• CPC Class Codes: A61M 37/0069 Devices for implanting pellets, e.g. markers or solid medicaments for introducing of radioactive sources for interstitial radiation therapy, i.e. brachytherapy A61N5/1027

Abstract

A drug depot implantable at or near a target tissue site beneath the skin of a patient is provided, the drug depot comprising a therapeutically effective amount of a drug; at least one line having a distal end and a proximal end, the proximal end of the line attached to the drug depot; an anchor attached to the distal end of the line and configured to limit movement of the drug depot at or near the target tissue site, wherein the drug depot is capable of releasing the therapeutically effective amount of the drug over a period of at least one day. In some embodiments, the drug depot provided can include an effective amount of at least analgesic and/or at least one anti-inflammatory agent at or near a target site, and can reduce, prevent or treat inflammation and/or pain.

Claims

1. A drug depot implantable at or near a target tissue site beneath the skin of a patient, the drug depot comprising a therapeutically effective amount of a drug;

at least one line having a distal end and a proximal end, the proximal end of the line attached to the drug depot;

an anchor attached to the distal end of the line and configured to limit movement of the drug depot at or near the target tissue site, wherein the drug depot is capable of releasing the therapeutically effective amount of the drug over a period of at least one day.

2. A drug depot according to claim 1, wherein the anchor comprises a biodegradable pellet, hook, staple, and/or barb.

3. A drug depot according to claim 1, wherein the drug depot is biodegradable and the line is attached to a distal end of the drug depot.

4. A drug depot according to claim 1, wherein the target tissue site is an annular tear.

5. A drug depot according to claim 1, wherein the at least one line comprises a suture, yarn, thread, and/or wire.

6. A drug depot according to claim 5, wherein the line is a biodegradable suture.

7. A drug depot according to claim 6, wherein the anchor is a biodegradable pellet.

8. A drug depot according to claim 1, wherein the drug depot, the at least one line and the anchor are biodegradable and the anchor degrades slower than the line and drug depot.

9. A drug depot according to claim 6, wherein the suture is attached to the anchor at a point off center.

10. A drug depot according to claim 6, wherein the anchor has a plurality of wings that open on delivery to the target tissue site.

11. A drug depot according to claim 6, wherein the suture is attached to the drug depot and/or the anchor by a knot, rim, bead or clip.

12. A drug depot implantable at or near a target tissue site beneath the skin of a patient, the drug depot comprising a therapeutically effective amount of a drug;

at least one suture having a distal end and a proximal end, the proximal end of the suture attached to the drug depot;

an anchor attached to the distal end of the suture and configured to limit movement of the drug depot at or near the target tissue site, wherein the drug depot is capable of releasing the therapeutically effective amount of the drug over a period of at least one day.

13. A drug depot according to claim 12, wherein the anchor comprises a biodegradable pellet, hook, and/or barb.

14. A drug depot according to claim 12, wherein the at least one suture is attached to a distal end of the drug depot.

15. A drug depot according to claim 12, wherein the target tissue site is an annular tear.

16. A drug depot according to claim 12, wherein the at least one suture is a biodegradable suture.

17. A drug depot according to claim 12, wherein the anchor has a plurality of wings that open on delivery to the target tissue site.

18. A drug depot according to claim 12, wherein the suture is attached to the anchor at a point off center.

19. A method of treating or preventing pain or inflammation in a patient in need of such treatment, the method comprising implanting one or more biodegradable drug depots comprising a therapeutically effective amount of an analgesic and/or anti-inflammatory agent at or near a target tissue site beneath the skin, wherein the one or more drug depots comprise at least one biodegradable suture having a distal end and a proximal end, the proximal end of the at least one suture attached to the one or more drug depots;

a biodegradable anchoring pellet attached to the distal end of the at least one suture and configured to limit movement of the one or more drug depots at or near the target tissue site, wherein the drug depot is capable of releasing the therapeutically effective amount of the drug over a period of at least three days.

20. A method of treating or preventing pain or inflammation in a patient in need of such treatment, according to claim 19, wherein the target tissue site is an annular tear.