MULTIFUNCTIONAL AND BIOLOGICALLY ACTIVE MATRICES FROM MULTICOMPONENT POLYMERIC SOLUTIONS
First Claim
1. A crosslinked matrix comprising at least two compatibilizing polymer-LMWH conjugates, wherein the compatibilizing polymer comprises PEG, and at least one crosslinking compound, wherein each compatibilizing polymer-LMWH conjugate is capable of assembly and comprises at least one compatibilizing polymer covalently bonded to at least one LMWH molecule, wherein each of the compatibilizing polymer-LMWH conjugates are partially noncovalently crosslinked with the same crosslinking compound, and wherein the crosslinking compound is an incorporated molecule comprising a heparin-binding growth factor or a heparin-binding compatibilizing polymer-peptide conjugate.
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Abstract
The present invention relates to a biologically active functionalized electrospun matrix to permit immobilization and long-term delivery of biologically active agents. In particular the invention relates to a functionalized polymer matrix comprising a matrix polymer, a compatibilizing polymer and a biomolecule or other small functioning molecule. In certain aspects the electrospun polymer fibers comprise at least one biologically active molecule functionalized with low molecular weight heparin. Examples of active molecules that may be used with the multicomponent polymer of the invention include, for example, a drug, a biopolymer, for example a growth factor, a protein, a peptide, a nucleotide, a polysaccharide, a biological macromolecule or the like. The invention is further directed to the formation of functionalized crosslinked matrices, such as hydrogels, that include at least one functionalized compatibilizing polymer capable of assembly.
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Citations
29 Claims
- 1. A crosslinked matrix comprising at least two compatibilizing polymer-LMWH conjugates, wherein the compatibilizing polymer comprises PEG, and at least one crosslinking compound, wherein each compatibilizing polymer-LMWH conjugate is capable of assembly and comprises at least one compatibilizing polymer covalently bonded to at least one LMWH molecule, wherein each of the compatibilizing polymer-LMWH conjugates are partially noncovalently crosslinked with the same crosslinking compound, and wherein the crosslinking compound is an incorporated molecule comprising a heparin-binding growth factor or a heparin-binding compatibilizing polymer-peptide conjugate.
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2-7. -7. (canceled)
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9. (canceled)
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11-20. -20. (canceled)
- 27. A crosslinked matrix comprising at least three compatibilizing polymer-LMWH conjugates, wherein the compatibilizing polymer comprises PEG, at least one incorporated molecule comprising a heparin-binding growth factor and at least one heparin-binding compatibilizing polymer-peptide conjugate wherein each compatibilizing polymer-LMWH conjugate is capable of assembly and comprises at least one compatibilizing polymer covalently bonded to at least one LMWH molecule, wherein at least two of the compatibilizing polymer-LMWH conjugates are partially noncovalently crosslinked with the same incorporated molecule, wherein at least two of the compatibilizing polymer-LMWH conjugates are partially noncovalently crosslinked with the same heparin-binding compatibilizing polymer-peptide conjugate.
Specification