APPARATUS AND METHODS FOR EFFICIENT PROCESSING OF BIOLOGICAL SAMPLES ON SLIDES
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Abstract
Methods for treating biological samples on microscope slides are set forth. One aspect of the invention is the use of predried reagents in wells on trays onto which the slides are placed, especially the use of predried reagents which dissolve sequentially. Yet another aspect of the invention is the use of external controls placed directly on a microscope slide in conjunction with a biological sample to be assayed. The external controls can be conveniently placed on a membrane which can be affixed to the slide. A further aspect of the invention is a specially designed tray to allow whole chromosome painting of all chromosomes of a cell sample on a single slide. The invention is also drawn to a coverslip with concave wells which act as reaction chambers when placed against a slide and filled with buffer. Preferably a reagent is predried in the well. A further aspect of the invention is a method of reacting samples on slides by placing them into a reaction chamber together with a coverslip which has a predried reagent on it.
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Citations
61 Claims
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1-42. -42. (canceled)
- 43. A multichamber coverslip comprising a group of connected coverslips which are spaced such that a single coverslip lines up with one or more slides in a slide holder of a system for processing biological samples.
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56. A method of performing an assay on a biological sample comprising,
placing a microscope slide having a biological sample into a slide holder of an integrated system for processing the biological samples, wherein the system further comprises a multichamber coverslip comprising a group of individual coverslips which are connected and spaced such that a single coverslip is lined up over the sample on a slide.
Specification