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METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES

  • US 20100113591A1
  • Filed: 11/05/2009
  • Published: 05/06/2010
  • Est. Priority Date: 06/23/2003
  • Status: Active Grant
First Claim
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1. A compound of Formula V:

  • wherein;

    A is nitrogen or oxygen;

    R11 is hydrogen, salt-forming cation, ester forming group, —

    (CH2)x-Q, or when A is nitrogen, A and R11 taken together may be the residue of a natural or unnatural amino acid or a salt or ester thereof, wherein A and R11 taken together are not a leucine residue;

    Q is hydrogen, thiazolyl, triazolyl, imidazolyl, benzothiazolyl, or benzoimidazolyl;

    x is 0, 1, 2, 3, or 4;

    n is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10;

    aa is a natural or unnatural amino acid residue;

    m is 1, 2, or 3;

    R14 is hydrogen or protecting group;

    R15 is hydrogen, alkyl or aryl; and

    pharmaceutically acceptable salts, esters, or prodrugs thereof;

    wherein when A is oxygen, R11 is hydrogen or a salt-forming cation, n is 2, m is 1, and R14 and R15 are both hydrogen, then aa is other than phenylalanine, and wherein when A is oxygen, R11 is hydrogen or a salt-forming cation, n is 2, 3 or 4, m is 2, and R14 and R15 are both hydrogen, then aa is other than D-phenylalanine.

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