Pharmaceutical Compositions

• US 20100113607A1
• Filed: 12/11/2009
• Published: 05/06/2010
• Est. Priority Date: 08/04/2000
• Status: Abandoned Application

• Current Assignee: Alfredo Emilio Bruno-Raimondi
• Original Assignee: Alfredo Emilio Bruno-Raimondi
• Inventors: Bruno-Raimondi, Alfredo Emilio
• Application Number:
  US12/635,793
• Publication Number:
  US 20100113607A1
• Time in Patent Office: Days
• US Class Current: 514/655
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/135 having aromatic rings , e.g. ketamine, nortriptyline methadone A61K31/137
• CPC Class Codes: A61K 31/41 having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
• CPC Class Codes: A61K 31/415 1,2-Diazoles
• CPC Class Codes: A61K 31/495 having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazinesA61K31/48 takes precedence ; with three nitrogen atoms A61K31/53
• CPC Class Codes: A61K 41/00 Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
• CPC Class Codes: A61K 41/0042 Photocleavage of drugs in vivo, e.g. cleavage of photolabile linkers in vivo by UV radiation for releasing the pharmacologically-active agent from the administered agent; photothrombosis or photoocclusion
• CPC Class Codes: A61K 41/17 by ultraviolet [UV] or infrared [IR] light, X-rays or gamma rays
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 31/10 Antimycotics

Abstract

A method for the topical treatment of nail diseases, e.g. onychomycosis, after preparation of the infected nail with a laser beam.

Claims

1. A method for the treatment of a nail infected with onychomycosis which method comprises forming one or more orifices in the nail with a device comprising an Erbium (Er:

YAG) laser or Holmium (Ho;

YAG) laser and administering an antifungal-containing pharmaceutical composition to the nail.

2. A method according to claim 1 wherein the antifungal-containing pharmaceutical composition is liquid, viscous or semi-solid.

3. A method according to claim 1 or 2 wherein the pharmaceutical composition comprises the antifungal in an amount of from 1 to 10% by weight of the composition.

4. A method according to claim 1 or 2 wherein the pharmaceutical composition comprises the antifungal in an amount of from 10 to 100% by weight of the composition.

5. A method according to claim 4 wherein the pharmaceutical composition comprises the antifungal in an amount of more than about 70% by weight of the composition.

6. A method according to claim 1 wherein the pharmaceutical composition comprises substantially pure antifungal powder.

7. A method according to any preceding claim which further comprises treatment of the nail with a surfactant before administering the antifungal-containing composition.

8. A method according to any preceding claim which method further comprises administering a protective layer onto the nail.

10. A method or use according to any preceding claim wherein the antifungal is an allyl amine such as terbinafine or naftifine, a benzylamine such as butenafine, and/or an azole-based antifungal such as tioconazole, econazole, oxiconazole, itroconazole, fluconazole, ketoconazole, miconazole and clotrimazole.

11. A method or use according to any preceding claim wherein the antifungal is terbinafine.

12. A terbinafine-containing pharmaceutical composition suitable for the use in a method according to any one of claims 1 to 8.

9. Use of an antifungal, e.g. terbinafine, to produce a medicament to be administered to penetrate effectively an orifice of a nail.

13. A device comprising

(a) a laser for perforating nail

(b) supporting means to fix/position the toe or finger to be treated,

(c) a pointing laser, and

(d) optionally a xyz translation stage module.

14. A device according to claim 13, wherein the perforating laser is an Erbium (Er:

YAG) or Holmium (Ho;

YAG) laser.

15. A device according to claim 13 or 14, wherein the pointing laser is a visible continuous wave (cw) laser e.g. a red He—

Ne laser or a laser diode.

16. A device according to any one of claims 13 to 15 further comprising means for monitoring the nail plate.