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PROPARGYL SUBSTITUTED NUCLEOSIDE COMPOUNDS AND METHODS

  • US 20100113759A1
  • Filed: 12/29/2009
  • Published: 05/06/2010
  • Est. Priority Date: 12/23/2003
  • Status: Abandoned Application
First Claim
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1. A nucleotide comprising a nucleobase disposed between a sugar or sugar analog and a propargylic moiety, wherein the nucleobase comprises a pyrimidine nucleobase or pyrimidine nucleobase analog, the propargylic moiety is covalently attached to the nucleobase at the C-5 position of the nucleobase, the sugar or sugar analog is covalently attached to the nucleobase at the N−

  • 1 position of the nucleobase, the sugar or sugar analog comprises a 5′

    -monophosphate group, 5′

    -diphosphate group, or 5′

    -triphosphate group, wherein the propargylic moiety comprises(i) a propargyl group covalently attached by its methylene carbon to the nucleobase,(ii) a detectable label, and(iii) a linker covalently linking the acetylene carbon of the propargyl group to the detectable label.

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