Portable Peritoneal Dialysis System

• US 20100114012A1
• Filed: 11/02/2009
• Published: 05/06/2010
• Est. Priority Date: 11/03/2008
• Status: Active Grant

• Current Assignee: Fresenius Medical Care Holdings Incorporated (Fresenius Medical Care AG)
• Original Assignee: Fresenius Medical Care Holdings Incorporated (Fresenius Medical Care AG)
• Inventors: Teo, Jiunn Yeong, Ofsthun, Norma J., Stennett, Amanda K., Sandford, Harold F., Lipps, Benjamin J., Ford, Cheryl
• Granted Patent: US 8,777,892 B2
• Time in Patent Office: Days
• US Class Current: 604/28
• CPC Class Codes: A61M 1/155 with treatment-fluid pumping means or components thereof
• CPC Class Codes: A61M 1/159 specially adapted for peritoneal dialysis
• CPC Class Codes: A61M 1/1694 with recirculating dialysing liquid
• CPC Class Codes: A61M 1/1696 with dialysate regeneration
• CPC Class Codes: A61M 1/28 Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
• CPC Class Codes: A61M 1/284 Continuous flow peritoneal dialysis [CFPD]
• CPC Class Codes: A61M 2209/088 on the body
• CPC Class Codes: B01D 61/244 comprising multiple dialysis steps

Abstract

A portable peritoneal dialysis system for a patient includes an inlet port for providing inflow to the patient'"'"'s peritoneal cavity, an outlet port for providing outflow from the patient'"'"'s peritoneal cavity, and a volume of dialysate for flow into and out of the patient'"'"'s peritoneal cavity, thereby removing from the dialysate uremic waste metabolites that have diffused into the dialysate. The portable peritoneal dialysis system also includes a closed liquid flow loop, including a pump, for flowing the dialysate into and out of the patient'"'"'s peritoneal cavity, and an organic- and phosphate-removing stage, including at least one replaceable cartridge in the closed liquid flow loop, the cartridge containing material for removing organic compounds and phosphate from dialysate removed from the patient'"'"'s peritoneal cavity. The portable peritoneal dialysis system further includes a urea- and ammonia-removing stage, including at least one replaceable cartridge in the closed liquid flow loop, the cartridge containing material for removing urea and ammonia from dialysate removed from the patient'"'"'s peritoneal cavity, the material being packed around semi-permeable hollow fibers with interior fiber walls that reject cations, thereby retaining cations in the dialysate.

Claims

1. A portable peritoneal dialysis system for a patient with renal dysfunction or failure comprising:

an inlet port for providing inflow to the patient'"'"'s peritoneal cavity;

an outlet port for providing outflow from the patient'"'"'s peritoneal cavity;

a volume of dialysate for flow into and out of the patient'"'"'s peritoneal cavity, thereby removing from the dialysate uremic waste metabolites that have diffused into the dialysate;

a closed liquid flow loop, including a pump, for flowing the dialysate into and out of the patient'"'"'s peritoneal cavity;

an organic- and phosphate-removing stage, including at least one replaceable cartridge in the closed liquid flow loop, the cartridge containing material for removing organic compounds and phosphate from dialysate removed from the patient'"'"'s peritoneal cavity; and

a urea- and ammonia-removing stage, including at least one replaceable cartridge in the closed liquid flow loop, the cartridge containing material for removing urea and ammonia from dialysate removed from the patient'"'"'s peritoneal cavity, the material being packed around semi-permeable hollow fibers with interior fiber walls that reject cations, thereby retaining cations in the dialysate.

2. The portable peritoneal dialysis system of claim 1, wherein the material in the cartridge for removing organic compounds and phosphate includes a mixture of activated carbon and zirconium oxide.

3. The portable peritoneal dialysis system of claim 2, wherein the material in the cartridge for removing organic compounds and phosphate is packed around semi-permeable hollow fibers.

4. The portable peritoneal dialysis system of claim 2, wherein the material in the cartridge for removing urea and ammonia includes urease and strong acid cation exchange resin or sorbent.

5. The portable peritoneal dialysis system of claim 4, wherein the sorbent includes an ion exchange sorbent.

6. The portable peritoneal dialysis system of claim 4, wherein the urease is in the form of cross-linked jack bean meal polyethylenimine-carbon composite.

7. The portable peritoneal dialysis system of claim 4, further including an ammonia-removing stage, including at least one replaceable cartridge in the closed liquid flow loop, the cartridge containing material for removing ammonia from dialysate removed from the patient'"'"'s peritoneal cavity, the material being packed around semi-permeable hollow fibers with interior fiber walls that reject cations, thereby retaining cations in the dialysate.

8. The portable peritoneal dialysis system of claim 7, wherein the hollow fibers with interior fiber walls that reject cations reject calcium, magnesium, potassium, and sodium cations.

9. The portable peritoneal dialysis system of claim 1, wherein the material in the cartridge for removing ammonia includes strong acid cation exchange resin or ion exchange sorbent.

10. The portable peritoneal dialysis system of claim 1, further including an organic- and phosphate-removing and pH-control stage, including at least one replaceable cartridge in the closed liquid flow loop, the cartridge containing material for removing organic compounds from dialysate removed from the patient'"'"'s peritoneal cavity and material for controlling the pH of the dialysate at or near physiological pH.

11. The portable peritoneal dialysis system of claim 10, wherein the material in the cartridge for removing organic compounds includes activated carbon, and the material in the cartridge for controlling the pH of the dialysate includes a mixture of zirconium oxide and sodium zirconium carbonate.

12. The portable peritoneal dialysis system of claim 1, wherein the system is configured as a belt adapted to be worn by the patient.

13. The portable peritoneal dialysis system of claim 1, wherein the system is configured as an integrated loop adapted to be worn by a patient as a belt or docked into a tabletop docking unit.

14. The portable peritoneal dialysis system of claim 1, wherein the system is configured as a tabletop unit.

15. A portable peritoneal dialysis system for a patient comprising:

an inlet port for providing inflow to the patient'"'"'s peritoneal cavity;

an outlet port for providing outflow from the patient'"'"'s peritoneal cavity;

a volume of dialysate that is infused into and moved out of the patient'"'"'s peritoneal cavity, thereby removing from the dialysate uremic waste metabolites that have diffused into the dialysate;

a closed liquid flow loop for circulating the dialysate from the patient, throughout the system and back into the patient;

a pump attached to the closed liquid flow loop for flowing the dialysate into the patient'"'"'s peritoneal cavity and flowing the dialysate containing uremic waste metabolites out of the patient'"'"'s peritoneal cavity;

an organic- and phosphate-removing stage, including at least one replaceable cartridge in the closed liquid flow loop, the cartridge containing material for removing organic compounds and phosphate from dialysate removed from the patient'"'"'s peritoneal cavity;

a urea- and ammonia-removing stage, including at least one replaceable urea- and ammonia-removing cartridge in the closed liquid flow loop, the cartridge containing material for removing urea and ammonia from dialysate removed from the patient'"'"'s peritoneal cavity, the material being packed around semi-permeable hollow fibers with interior fiber walls that reject cations, thereby retaining calcium, magnesium, potassium, and sodium cations in the dialysate;

an ammonia-removing stage, including at least one replaceable cartridge in the closed liquid flow loop, the cartridge comprising material for removing ammonia, the material being packed around semi-permeable hollow fibers with interior fiber walls that reject cations, thereby retaining calcium, potassium, and sodium cations in the dialysate; and

an organic- and phosphate-removing and pH-control stage, including at least one replaceable cartridge in the closed liquid flow loop, the cartridge containing material for removing organic compounds and material for controlling the pH of the dialysate at or near physiological pH.

16. A method for providing peritoneal dialysis to a patient using a portable peritoneal dialysis system including a closed liquid flow loop for flowing a volume of dialysate into and out of the patient'"'"'s peritoneal cavity and through dialysate regenerating stages, comprising:

a) flowing a volume of dialysate from the patient'"'"'s peritoneal cavity through an organic- and phosphate-removing stage, including at least one replaceable cartridge in the closed liquid flow loop, the cartridge containing material for removing organic compounds and phosphate from dialysate removed from the patient'"'"'s peritoneal cavity;

thereafter

b) flowing the volume of dialysate through semi-permeable hollow fibers contained in a urea- and ammonia-removing stage, including at least one replaceable cartridge in the closed liquid flow loop, the cartridge containing material for removing urea and ammonia from dialysate removed from the patient'"'"'s peritoneal cavity, the material being packed around the semi-permeable hollow fibers, the semi-permeable hollow fibers having interior fiber walls that reject cations, thereby retaining cations in the dialysate while removing from the dialysate uremic waste metabolites that have diffused into the dialysate, to produce regenerated dialysate; and

c) introducing the regenerated dialysate into the patient'"'"'s peritoneal cavity.

17. The method for providing peritoneal dialysis to a patient of claim 16, wherein the material in the cartridge for removing organic compounds and phosphate includes a mixture of activated carbon and zirconium oxide.

18. The method for providing peritoneal dialysis to a patient of claim 17, wherein the material in the cartridge for removing organic compounds and phosphate is packed around semi-permeable hollow fibers.

19. The method for providing peritoneal dialysis to a patient of claim 17, wherein the material in the cartridge for removing urea and ammonia includes urease and strong acid cation exchange resin or sorbent.

20. The method for providing peritoneal dialysis to a patient of claim 19, wherein the sorbent includes an ion exchange sorbent.

21. The method for providing peritoneal dialysis to a patient of claim 19, wherein the urease is in the form of cross-linked jack bean meal polyethylenimine-carbon composite.

22. The method for providing peritoneal dialysis to a patient of claim 19, further including flowing the volume of dialysate through an ammonia-removing stage, including at least one replaceable cartridge in the closed liquid flow loop, the cartridge containing material for removing ammonia from dialysate removed from the patient'"'"'s peritoneal cavity, the material being packed around semi-permeable hollow fibers with interior fiber walls that reject cations, thereby retaining cations in the dialysate.

23. The method for providing peritoneal dialysis to a patient of claim 22, wherein the hollow fibers with interior fiber walls that reject cations reject calcium, magnesium, potassium, and sodium cations.

24. The method for providing peritoneal dialysis to a patient of claim 16, wherein the material in the cartridge for removing ammonia includes strong acid cation exchange resin or ion exchange sorbent.

25. The method for providing peritoneal dialysis to a patient of claim 16, further including flowing the volume of dialysate through an organic- and phosphate-removing and pH-control stage, including at least one replaceable cartridge in the closed liquid flow loop, the cartridge containing material for removing organic compounds from dialysate removed from the patient'"'"'s peritoneal cavity and material for controlling the pH of the dialysate at or near physiological pH.

26. The method for providing peritoneal dialysis to a patient of claim 25, wherein the material in the cartridge for removing organic compounds includes activated carbon, and the material in the cartridge for controlling the pH of the dialysate includes a mixture of zirconium oxide and sodium zirconium carbonate.

27. The method for providing peritoneal dialysis to a patient of claim 16, wherein the system is configured as a belt adapted to be worn by the patient.

28. The method for providing peritoneal dialysis to a patient of claim 16, wherein the system is configured as an integrated loop adapted to be worn by a patient as a belt or docked into a tabletop docking unit.

29. The method for providing peritoneal dialysis to a patient of claim 16, wherein the system is configured as a tabletop unit.