INTRALUMENALLY-IMPLANTABLE FRAMES

• US 20100114296A1
• Filed: 10/26/2009
• Published: 05/06/2010
• Est. Priority Date: 04/24/2003
• Status: Active Grant

• Current Assignee: Cook Incorporated (Cook Group Incorporated)
• Original Assignee: Cook Incorporated (Cook Group Incorporated)
• Inventors: Case, Brian C., Flagle, Jacob A., Garrison, Michael L.
• Granted Patent: US 8,157,857 B2
• Time in Patent Office: Days
• US Class Current: 623/1.160
• CPC Class Codes: A61F 2/06 Blood vessels
• CPC Class Codes: A61F 2/2418 Scaffolds therefor, e.g. support stents
• CPC Class Codes: A61F 2/2475 Venous valves
• CPC Class Codes: A61F 2/86 Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2/915 with bands having a meander structure, adjacent bands being connected to each other
• CPC Class Codes: A61F 2002/068 Modifying the blood flow model, e.g. by diffuser or deflector
• CPC Class Codes: A61F 2002/91508 the meander having a difference in amplitude along the band
• CPC Class Codes: A61F 2002/91516 the meander having a change in frequency along the band
• CPC Class Codes: A61F 2002/91533 characterised by the phase between adjacent bands
• CPC Class Codes: A61F 2002/91575 connected peak to trough
• CPC Class Codes: A61F 2220/0016 with sharp anchoring protrusions, e.g. barbs, pins, spikes
• CPC Class Codes: A61F 2220/0058 soldered or brazed or welded
• CPC Class Codes: A61F 2230/0054 V-shaped
• CPC Class Codes: A61F 2250/0037 differing in height or in length
• CPC Class Codes: A61F 2250/0039 differing in diameter

Abstract

Implantable frames for use in body passages are provided herein. The implantable frames can include a plurality of hoop members joined by a plurality of longitudinal connecting members to form a tubular frame defining a cylindrical lumen. The plurality of longitudinal connecting members may include first and second longitudinal connecting members joining a first hoop member to a second hoop member such that the first and second longitudinal connecting members extend across an entire space separating the first and second hoop members.

Claims

1. An implantable frame defining a lumen extending between a proximal end and a distal end along a longitudinal axis, the implantable frame having a substantially cylindrical exterior surface area with a plurality of openings, the implantable frame moveable between a compressed state and an expanded state, the implantable frame comprising:

a first hoop member and a second hoop member axially adjacent to the first hoop member, each of the first and second hoop members comprising a plurality of interconnected struts and bends arranged in an undulating shape;

the first hoop member comprising a first bend having a first apex and connecting first and second circumferentially adjacent struts;

first and second longitudinal connecting members joining the first hoop member to the second hoop member, the first and second longitudinal connecting members extending across an entire space separating the first and second hoop members;

wherein the first longitudinal connecting member has a first end attached to the first apex; and

wherein the second longitudinal connecting member has a second end attached to the first apex.

2. The implantable frame of claim 1, wherein the second hoop member comprises a second bend connecting third and fourth circumferentially adjacent struts;

wherein the first longitudinal connecting member has a third end attached to the second bend; and

wherein the second longitudinal connecting member has a fourth end attached to the second bend.

3. The implantable frame of claim 1, wherein the first and second longitudinal connecting members are disposed parallel to each other.

4. The implantable frame of claim 1, wherein each of the first and second hoop members has a substantially equal radius and the first and second hoop members are concentrically aligned along the longitudinal axis.

5. The implantable frame of claim 1, wherein the implantable frame comprises 2-16 longitudinal connecting members;

and

wherein each longitudinal connecting member of the 2-16 longitudinal connecting members extends across the entire space separating the first and second hoop members.

6. The implantable frame of claim 1, wherein the implantable frame is self-expandable.

7. The implantable frame of claim 6, wherein the implantable frame comprises a shape memory alloy.

8. The implantable frame of claim 7, wherein the shape memory alloy comprises a nickel titanium alloy.

9. The implantable frame of claim 7, wherein the shape memory alloy comprises a member of the group consisting of Au—

Cd, Cu—

Zn, In—

Ti, Cu—

Zn—

Al, Ti—

Nb, Au—

Cu—

Zn, Cu—

Zn—

Sn, CuZn—

Si, Cu—

Al—

Ni, Ag—

Cd, Cu—

Sn, Cu—

Zn—

Ga, Ni—

Al, Fe—

Pt, U—

Nb, Ti—

Pd—

Ni, and Fe—

Mn—

Si alloys.

10. The implantable frame of claim 1, wherein the implantable frame requires mechanical expansion to move from the compressed state to the expanded state.

11. The implantable frame of claim 10, wherein the implantable frame comprises a member selected from the group consisting of stainless steel, tantalum, platinum alloys, niobium alloys, and cobalt alloys.

12. The implantable frame of claim 10, wherein the implantable frame comprises a cobalt chromium alloy.

13. The implantable frame of claim 1, wherein the implantable frame comprises a polymer.

14. The implantable frame of claim 13, wherein the polymer comprises polyethylene (PE);

polypropylene (PP);

polyisobutylene;

poly(alpha olefin);

alkyl (alkyl)acrylates;

poly(ethyl acrylate);

parylene;

ethyl vinyl acetate (EVA);

poly(ethylene-co-vinyl acetate) (PEVA);

or copolymers or mixtures thereof.

15. The implantable frame of claim 1, wherein the implantable frame includes a bioactive agent.

16. The implantable frame of claim 15, wherein the bioactive agent comprises an anti-angiogenic or antineoplastic bioactive.

17. The implantable frame of claim 16, wherein the bioactive agent comprises one or more of paclitaxel, sirolimus, a rapamycin analog, and a metalloproteinase inhibitor.

18. The implantable frame of claim 15, wherein the bioactive agent comprises an antithrombogenic bioactive.

19. The implantable frame of claim 1, wherein the first and second longitudinal connecting members are positioned such that an angle less than (2n/n) radians is subtended by a hypothetical arc extending circumferentially along the exterior surface area of the implantable frame between a first radius extending from the longitudinal axis to the first longitudinal connecting member and a second radius extending from the longitudinal axis to the second longitudinal connecting member, where (n) is an integer equal to 2 or greater.

20. An implantable frame defining a lumen extending between a proximal end and a distal end along a longitudinal axis, the implantable frame having a substantially cylindrical exterior surface area with a plurality of openings, the implantable frame moveable between a compressed state and an expanded state, the implantable frame comprising:

a first hoop member and a second hoop member axially adjacent to the first hoop member, each of the first and second hoop members comprising a plurality of interconnected struts and bends arranged in an undulating shape;

the first hoop member comprising a first bend having a first apex and connecting first and second circumferentially adjacent struts;

the second hoop member comprising a second bend connecting third and fourth circumferentially adjacent struts; and

first and second longitudinal connecting members joining the first hoop member to the second hoop member, the first and second longitudinal connecting members extending across an entire space separating the first and second hoop members;

wherein the first longitudinal connecting member has a first end attached to the first apex and a second end attached to the second bend;

wherein the second longitudinal connecting member has a third end attached to the first apex and a fourth end attached to the second bend; and

wherein the first and second longitudinal connecting members are disposed parallel to each other.

21. An implantable frame defining a lumen extending between a proximal end and a distal end along a longitudinal axis, the implantable frame having a substantially cylindrical exterior surface area with a plurality of openings, the implantable frame moveable between a compressed state and an expanded state, the implantable frame comprising:

a first hoop member and a second hoop member axially adjacent to the first hoop member, each of the first and second hoop members comprising a plurality of interconnected struts and bends arranged in an undulating shape; and

a plurality of longitudinal connecting members, each longitudinal connecting member of the plurality of longitudinal connecting members extending across the entire space separating the first and second hoop members and having a first end attached to a bend of the first hoop member and a second end attached to a bend of the second hoop member;

wherein a first bend of the first hoop member is attached to each longitudinal connecting member of a pair of longitudinal connecting members of the plurality of longitudinal connecting members; and

wherein a second bend of the second hoop member is attached to each longitudinal connecting member of the pair of longitudinal connecting members.