Compositions and methods for therapeutic delivery with frozen particles

• US 20100114497A1
• Filed: 10/31/2008
• Published: 05/06/2010
• Est. Priority Date: 10/31/2008
• Status: Active Grant

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: Searete LLC A Limited Liability Corporation of The State of Delaware
• Inventors: Myhrvold, Nathan P., Boyden, Edward S., Wood, Lowell L. JR., Hyde, Roderick A., Sweeney, Elizabeth A., Leuthardt, Eric C.
• Granted Patent: US 8,731,841 B2
• Time in Patent Office: Days
• US Class Current: 702/19
• CPC Class Codes: A61K 9/14 Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles microspheres A61K9/16; microcapsules A61K9/50; nanocapsules, nanoparticles of the matrix type A61K9/51
• CPC Class Codes: A61M 2005/005 Magazines with multiple ampoules directly inserted into an injection or infusion device, e.g. revolver-like magazines containing ampoules with or without needles
• CPC Class Codes: A61M 2205/3306 Optical measuring means
• CPC Class Codes: A61M 5/3015 for injecting a dose of particles in form of powdered drug, e.g. mounted on a rupturable membrane and accelerated by a gaseous shock wave or supersonic gas flow cell injection devices C12M3/006
• CPC Class Codes: G16H 20/10 relating to drugs or medications, e.g. for ensuring correct administration to patients
• CPC Class Codes: G16H 20/30 relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
• CPC Class Codes: Y02A 90/10 Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.

Claims

1. A system comprising:

at least one computer program, configured with a computer-readable medium, for use with at least one computer system and wherein the computer program includes a plurality of instructions including but not limited to;

one or more instructions for comparing information regarding at least one aspect of at least one therapeutic administration of at least one frozen particle therapeutic composition to at least one biological tissue of at least one subject, and information regarding at least one clinical outcome following receipt by the at least one subject of at least one frozen particle therapeutic composition.

2. The system of claim 1, wherein the information regarding at least one aspect of therapeutic administration of at least one frozen particle therapeutic composition includes information regarding amount of the at least one therapeutic composition or therapeutic agent administered to at least one biological tissue of at least one subject.

3. The system of claim 1, wherein the information regarding at least one aspect of therapeutic administered of at least one frozen particle therapeutic composition includes information regarding at least one dimension of biological tissue penetration.

4. The system of claim 3, wherein the information regarding at least one dimension of biological tissue penetration includes information regarding at least one of depth, width, or breadth of administration of at least one frozen particle therapeutic composition to at least one biological tissue of at least one subject.

5. The system of claim 1, wherein the computing device is configured to communicate with at least one printing device, at least one imaging device, or at least one input device.

6. The system of claim 1, wherein the information regarding at least one aspect of therapeutic administration of at least one frozen particle therapeutic composition includes information regarding two or more subjects with one or more common attributes.

7. The system of claim 1, wherein the information regarding at least one aspect of therapeutic administration of at least one frozen particle therapeutic composition includes information regarding at least one cellular or tissue source.

8. The system of claim 7, wherein the information regarding at least one cellular or tissue source includes information regarding at least one abnormal cellular or tissue source.

9. The system of claim 7, wherein information regarding the at least one cellular or tissue source includes information regarding at least one type of cell or tissue.

10. The system of claim 1, wherein the at least one frozen particle therapeutic composition includes at least one of nitrogen, carbon dioxide, hydrogen oxide, helium, neon, xenon, krypton, air, oxygen, chlorine, oxygen, air, bromine, argon, polyethylene glycol, acetone, ethyl acetate, dimethyl sulfoxide, dimethyl formamide, dioxane, hexamethylphosphorotriamide, perfluorohydrocarbon, methanol, ethanol, tert-butyl alcohol, formic acid, hydrogen fluoride, ammonia, acetic acid, benzene, carbon tetrachloride, acetonitrile, hexane, methylene chloride, carboxylic acid, saline, Ringer'"'"'s solution, lactated Ringer'"'"'s solution, Hartmann'"'"'s solution, acetated Ringer'"'"'s solution, phosphate buffered solution, TRIS-buffered saline solution, Hank'"'"'s balanced salt solution, Earle'"'"'s balanced salt solution, standard saline citrate, HEPES-buffered saline, dextrose, glucose, or diethyl ether.

11. The system of claim 1, wherein the at least one frozen particle therapeutic composition includes at least one major dimension of approximately one centimeter or less, approximately one millimeter or less, approximately one micrometer or less, approximately one nanometer or less, or any value therebetween.

12. The system of claim 1, wherein the at least one frozen particle therapeutic composition includes one or more reinforcement agents.

13. The system of claim 1, wherein the at least one frozen particle therapeutic composition includes one or more explosive materials.

14. The system of claim 1, wherein the receipt by the at least one subject of at least one frozen particle therapeutic composition is pursuant to at least one clinical trial.

15. The system of claim 1, further comprising determining at least one correlation before the administration of the at least one frozen particle therapeutic composition.

16. The system of claim 1, further comprising creating at least one inclusion criterion and at least one exclusion criterion for a clinical trial involving the at least one frozen particle therapeutic composition.

17. The system of claim 1, further comprising suggesting the inclusion of one or more of the at least one subject in at least one clinical trial.

18. The system of claim 1, further comprising suggesting the exclusion of one or more of the at least one subject in at least one clinical trial.

19. The system of claim 1, further comprising using one or more of the at least one comparison to predict at least one clinical outcome regarding at least one second subject.

20. The system of claim 19, wherein the at least one second subject has not received the at least one frozen particle therapeutic composition.

21. The system of claim 1, wherein using one or more of the at least one comparison further comprises predicting at least one clinical outcome involving the at least one second subject, wherein the at least one second subject is a plurality of people;

and segregating subject identifiers associated with the plurality of people in reference to the predicted at least one clinical outcome.

22. The system of claim 1, wherein using one or more of the at least one comparison includes the at least one second subject is a plurality of people;

and determining the eligibility of the at least one second subject for the at least one clinical trial.

23. A system, comprising:

at least one computer program, configured with a computer-readable medium, for use with at least one computer system and wherein the computer program includes a plurality of instructions including but not limited to;

one or more instructions for comparing information regarding at least one aspect of at least one therapeutic administration of at least one frozen particle therapeutic composition to at least one biological tissue of at least one subject, and information regarding at least one frozen particle therapeutic composition involving the at least one biological tissue of the at least one subject; and

one or more instructions for applying one or more comparisons to the information regarding the at least one aspect of therapeutic administration of at least one frozen particle therapeutic composition to a plurality of people.

24. The system of claim 23, further comprising one or more instructions for segregating subject identifiers associated with the plurality of people in reference to at least one of the one or more applied comparisons.

25. The system of claim 23, wherein the information regarding at least one aspect of the therapeutic administration of at least one frozen particle therapeutic composition includes information regarding the amount of therapeutic composition or therapeutic agent administered to at least one biological tissue of at least one subject.

26. The system of claim 23, wherein the information regarding at least one aspect of the therapeutic administration of at least one frozen particle therapeutic composition includes information regarding at least one dimension of biological tissue penetration.

27. The system of claim 26, wherein the information regarding at least one dimension of biological tissue penetration includes information relating to at least one of depth, width, or breadth of administration of the at least one frozen particle therapeutic composition to at least one biological tissue of at least one subject.

28. The system of claim 23, further comprising one or more instructions for segregating individual identifiers associated with the plurality of people in reference to at least one characteristic shared by two or more subjects in the plurality of people.