EXTRACELLULAR MATRIX MODULATING COATINGS FOR MEDICAL DEVICES
First Claim
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1. A medical device, comprising:
- a coating having a composition configured to (i) allow formation of a protective tissue over an implanted device, and (ii) control development of extracellular matrix near the implanted device.
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Abstract
A unique method and coatings are provided to promote/allow early stage tissue encapsulation/endothelization of medical devices while effectively controlling excessive tissue buildup by eluting antiproliferative therapeutic agent within a body of a patient. The method involves using a therapeutic agent that suppresses excessive extracellular matrix proliferation and allows/promotes thin tissue healing/encapsulation/endothelization of the device. Optimized timing of onset of elution to match onset of excessive extracellular matrix proliferation for maximum effectiveness is achieved by delay barrier with biochemical switch.
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20 Claims
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1. A medical device, comprising:
- a coating having a composition configured to (i) allow formation of a protective tissue over an implanted device, and (ii) control development of extracellular matrix near the implanted device.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
Specification