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COMBINATION THERAPY OF SUBSTITUTED OXAZOLIDINONES

  • US 20100120718A1
  • Filed: 10/19/2007
  • Published: 05/13/2010
  • Est. Priority Date: 11/02/2006
  • Status: Abandoned Application
First Claim
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1. A combination comprisingA) a compound of the formula (I) in which R1 is 2-thiophene which is substituted in position 5 by a radical from the group of chlorine, bromine, methyl or trifluoromethyl, R2 is D-A-:

  • where;

    the radical “

    A”

    is phenylene;

    the radical “

    D”

    is a saturated 5- or 6-membered heterocycle which is linked via a nitrogen atom to “

    A”

    ,which has a carbonyl group in direct vicinity to the linking nitrogen atom, andin which a ring carbon member may be replaced by a heteroatom from the series S, N and O;

    wherethe group “

    A”

    defined above may optionally be substituted once or twice in the meta position relative to the linkage to the oxazolidinone by a radical from the group of fluorine, chlorine, nitro, amino, trifluoromethyl, methyl or cyano, R3, R4, R5, R6, R7 and R8 are hydrogen, the pharmaceutically acceptable salts, hydrates, prodrugs thereof or mixtures thereof B) acetylsalicylic acid and C) an ADP receptor antagonist.

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