PRODRUGS OF FUSED HETEROCYCLIC INHIBITORS OF D-AMINO ACID OXIDASE
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Abstract
The invention relates to prodrugs of fused heterocyclic inhibitors of D-amino oxidase (DAAO) and methods of treating diseases and conditions, wherein modulation of D-amino acid oxidase activity, D-serine levels, D-serine oxidative products and NMDA receptor activity in the nervous system of a mammalian subject is effective.
85 Citations
50 Claims
- 1. A compound having a structure according to the formula
- 2. A compound having the formula:
- 3. A compound having the formula:
- 42. A compound comprising a first cyclic structure and a second cyclic structure linked by a linker moiety, said compound having a structure selected from the group:
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46. A compound comprising a first cyclic structure and a second cyclic structure linked by a linker moiety, said compound having a structure:
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47. A compound having a structure according to any of the prodrugs of Table 1.
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48. A compound having a structure according to any of the prodrugs of Table 2.
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49. A compound having a structure according to any of the prodrugs of Table 3.
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50. A compound having a structure according to any of the prodrugs of Formulae D-P.
Specification