DELIVERY SYSTEM AND METHOD FOR INTERSTITIAL RADIATION THERAPY

• US 20100121130A1
• Filed: 01/21/2010
• Published: 05/13/2010
• Est. Priority Date: 11/02/2001
• Status: Active Grant

• Current Assignee: Eckert & Ziegler BEBIG S.A (Eckert & Ziegler AG)
• Original Assignee: Biocompatibles Incorporated (Boston Scientific Corporation)
• Inventors: Terwilliger, Richard A., Lamoureux, Gary A.
• Granted Patent: US 7,942,803 B2
• Time in Patent Office: Days
• US Class Current: 600/8
• CPC Class Codes: A61N 2005/1023 Means for creating a row of seeds, e.g. spacers
• CPC Class Codes: A61N 2005/1024 Seeds
• CPC Class Codes: A61N 5/1007 Arrangements or means for the introduction of sources into the body
• CPC Class Codes: A61N 5/1027 Interstitial radiation therapy
• CPC Class Codes: B29C 48/03 characterised by the shape of the extruded material at extrusion
• CPC Class Codes: B29C 48/151 Coating hollow articles
• CPC Class Codes: B29C 48/157 Coating linked inserts, e.g. chains
• CPC Class Codes: G21G 4/08 specially adapted for medical application radiation therapy using radioactive sources A61N5/10

Abstract

A prescription method of treating tissue comprises the steps of accepting a prescription tissue treatment plan for the tissue to be treated, positioning seeds relative to each other per the prescription tissue treatment plan such that the positions of seeds relative to each other is only established by the prescription tissue treatment plan, and creating a treatment strand by heating and cooling a material to position the plurality of treatment seeds in the material. The prescription tissue treatment plan specifies a number and a spacing of the seeds to be provided in the treatment strand, the spacing of the treatment seeds being unrestricted by any use of spacers and independently set by and according to the prescription tissue treatment plan.

Claims

1. A prescription method of treating tissue comprising the steps of:

accepting a prescription tissue treatment plan for the tissue to be treated, said prescription tissue treatment plan specifying a number and a spacing of a plurality of treatment seeds to be provided in a treatment strand, the spacing of said plurality of treatment seeds being unrestricted by any use of spacers and independently set by and according to the prescription tissue treatment plan;

positioning the seeds relative to each other per the prescription tissue treatment plan such that the positions of seeds relative to each other is only established by the prescription tissue treatment plan; and

creating the treatment strand by heating and cooling a material to position said plurality of treatment seeds in the material.

2. The method of claim 1 wherein:

said prescription tissue treatment plan specifies that the plurality of treatment seeds is a plurality of radioactive seeds and specifies a plurality of optimal spacing between each pair of seeds; and

said creating step creates a plurality of treatment strands to the specified optimal spacings prescribed by the treatment plan.

3. The method of claim 2 wherein:

said creating step further includes using the material in a fluid form to at least partially encapsulate the plurality of radioactive seeds in the specified optimal spacings.

4. The method of claim 1 wherein:

said creating step further includes using the material in a fluid form to at least partially encapsulate the plurality of seeds.

5. The method of claim 1 wherein the material is heated and used in a fluid form and cooled to set the spacing between the seeds per the prescription tissue treatment plan.

6. The method of claim 3 wherein:

the material is a bio-absorbable material.

7. A prescription method of treating tissue comprising the steps of:

accepting a prescription tissue treatment plan for the tissue to be treated, said prescription tissue treatment plan specifying the spacing of a plurality of treatment seeds to be provided in a treatment strand;

positioning the seeds relative to each other per the prescription tissue treatment plan such that the positions of the seeds relative to each other is only established by the prescription tissue treatment plan; and

creating at least one said treatment strand by heating and cooling a material to maintain relative positioning of said treatment seeds so that the spacing between said treatment seeds is set as specified by said prescription tissue treatment plan.

8. The method of claim 7 wherein the material is heated and used in a fluid form and cooled to set the spacing between the seeds per the prescription tissue treatment plan.

9. The method of claim 7 wherein said accepting step further comprises accepting said prescription tissue treatment plan created using an imaging device to image the tissue for which the prescription tissue treatment plan is prescribed.

10. The method of claim 7 wherein the accepting step further comprises accepting the prescription tissue treatment plan wherein said prescription tissue treatment plan is created by a computer program.

11. A prescription method of treating tissue comprising the steps of:

accepting a prescription tissue treatment plan for the tissue to be treated, said prescription tissue treatment plan specifying a number and a spacing of a plurality of treatment seeds to be provided in a treatment strand,

positioning the seeds relative to each other per the prescription tissue treatment plan such that the positions of seeds relative to each other is established only by the prescription tissue treatment plan; and

creating the treatment strand by heating and cooling a material to position the plurality of treatment seeds in the material in accordance with the prescription tissue treatment plan.

12. The method of claim 11 wherein the material is heated and used in a fluid form and cooled to set the spacing between the seeds per the prescription tissue treatment plan.

13. The method of claim 11 wherein:

said accepting step further comprises accepting the prescription tissue treatment plan wherein said prescription tissue treatment plan is created by a computer program.

14. The method of claim 11 wherein:

said accepting step further comprises accepting the treatment plan wherein the prescription tissue treatment plan specifies using a plurality of radioactive seeds and optimal spacings between each pair of said plurality of radioactive seeds; and

said creating step further comprises creating a plurality of said treatment strands to the specified optimal spacings prescribed.

15. An implant for treatment of patient tissue in accordance with a prescription tissue treatment plan, the implant comprising:

a treatment strand including a plurality of treatment seeds;

wherein the treatment strand is adapted to be implanted into patient tissue using a hollow needle; and

wherein a spacing of said treatment seeds is defined by the treatment plan

wherein the spacing of said treatment seeds is set during manufacturing by positioning the seeds relative to each other per the prescription tissue treatment plan such that the positions of seeds relative to each other is only established by the prescription tissue treatment plan; and

wherein a material is heated and cooled to maintain relative positioning of the treatment seeds in the material.

16. The implant of claim 15, wherein said treatment seeds comprise a plurality of radioactive seeds.

17. An implant for treatment of patient tissue in accordance with a prescription tissue treatment plan, the implant comprising:

a treatment strand including a plurality of treatment seeds within the treatment strand;

wherein the treatment strand is created by;

accepting a prescription tissue treatment plan for the tissue to be treated, said prescription tissue treatment plan specifying the spacing of said treatment seeds to be provided in the treatment strand, the spacing of said treatment seeds being only established by prescription according to the prescription tissue treatment plan and

positioning the seeds relative to each other per the prescription tissue treatment plan such that the positions of seeds relative to each other is established only by the prescription tissue treatment plan; and

heating a material to allow the material to flow relative to said treatment seeds and to set the position of said treatment seeds relative to each other with that the spacing between said treatment seeds specified by said prescription tissue treatment plan.

18. The implant of claim 17, wherein the treatment strand comprises said treatment seeds encapsulated within a bio-absorbable polymeric material.

19. The implant of claim 17, wherein said treatment seeds comprise a plurality of radioactive seeds.

20. The implant of claim 17, wherein the treatment strand is substantially cylindrical and has a longitudinal length, and wherein a diameter of the substantially cylindrical treatment strand is substantially constant along the longitudinal length.

21. The implant of claim 17, wherein the seeds are radioactive seeds.