Subcutaneous Glucose Electrode
0 Assignments
0 Petitions
Accused Products
Abstract
A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow “one-point” in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably three or four-layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited (third layer). An outer (fourth) layer is biocompatible.
1 Citation
21 Claims
-
1. (canceled)
-
2. A method of detecting an analyte in a host, comprising:
-
a) inserting a sensor through a host'"'"'s skin and into the host, wherein the sensor is a component of an analyte sensing device configured for transcutaneous insertion into the host, wherein the sensor has an architecture with at least one dimension less than about 1 mm, and wherein a biointerface covers at least a portion of the sensor, whereby fluid flows into the biointerface upon insertion of the sensor into the host; b) detecting from the sensor a signal indicative of a presence or a concentration of the analyte in the host; and c) removing the sensor from the host. - View Dependent Claims (3, 4)
-
-
5. A method for fabricating an analyte sensor configured for insertion into a host'"'"'s soft tissue, the method comprising:
-
forming a biointerface having a plurality of passageways and a solid portion on at least a sensing portion of a sensor, wherein the sensor is configured to measure an analyte in the host, and wherein the sensor has an architecture with at least one dimension less than about 1 mm. - View Dependent Claims (6, 7, 8, 9, 10, 11)
-
-
12. A method for fabricating an analyte sensor configured to be wholly implanted in a host'"'"'s soft tissue, the method comprising:
-
providing a sensor configured to measure an analyte in the host, wherein the sensor has an architecture with at least one dimension less than about 1 mm; and coating a biointerface onto the sensor, the biointerface comprising a plurality of cavities and a solid portion. - View Dependent Claims (13, 14, 15, 16, 17)
-
-
18. A method for making an analyte sensor configured for insertion into a host'"'"'s soft tissue, the method comprising:
-
providing a sensor configured to measure an analyte in a host, wherein the sensor has an architecture with at least one dimension less than about 1 mm; and directly writing a porous biointerface, wherein the porous biointerface is written based on a predefined pattern stored in a computer system. - View Dependent Claims (19, 20, 21)
-
Specification