Subcutaneous Glucose Electrode
First Claim
1. An electrochemical sensor comprising:
- one or more non-corroding metal or carbon electrodes;
a sensing layer comprising an enzyme coupled to each electrode; and
a biocompatible layer comprising a biocompatible hydrogel chemically bound to the sensing layer of each electrode.
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Accused Products
Abstract
A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow “one-point” in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably three or four-layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited (third layer). An outer (fourth) layer is biocompatible.
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Citations
1 Claim
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1. An electrochemical sensor comprising:
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one or more non-corroding metal or carbon electrodes; a sensing layer comprising an enzyme coupled to each electrode; and a biocompatible layer comprising a biocompatible hydrogel chemically bound to the sensing layer of each electrode.
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Specification