REGULATED DRUG DELIVERY SYSTEM
First Claim
1. A drug delivery device for regulating delivery of a drug to a patient, the device comprising:
- a regulator for controllably varying the rate of delivery or dose of a drug passing to the patient;
at least one sensor for measuring a biochemical, biological or physiological property of the patient, said property being associated with the drug to be delivered or with a condition to be treated by the drug to be delivered, and generating a signal corresponding to said measured property;
a controller, in communication with the at least one sensor and the regulator, configured to control the rate of delivery or dose of the drug provided by the regulator in response to one or more measured biochemical, biological or physiological properties provided by the at least one sensor with respect to a target,the controller comprisinga comparator having a signal input configured to receive an input signal from at least one sensor and being capable of generating an error signal corresponding to the disparity between a target value and an input signal;
an active control component for generating an active output signal in response to the error signal; and
a manipulation component for manipulating the active output signal and generating a post-manipulation signal for communication to the regulator as a final output signal,characterized in that;
the controller further comprises an anti-wind up component for reducing or inhibiting the effect of signal wind up in the active control component; and
/orthe manipulation component comprises a filter sub-component for conditioning the active output signal,whereby the final output signal provides a controlled rate of delivery or dosage administered to a patient in response to the measured property.
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Abstract
A drug delivery device for regulating delivery of a drug to a patient (105) provides a controlled rate of delivery which accounts for changes in health or required dose and, in systems with inherent lag, enables a rapid and accurate response whilst maintaining system stability. The device comprises a drug delivery or dose regulator (103); a sensor (107) for measuring a biochemical or physiological property associated with the drug or the condition to be treated; and a controller (109) configured to control the rate of delivery or dose of drug via the regulator in response to the difference in a measured biochemical or physiological property with respect to a target. In order to maintain the system stability, the controller comprises an anti-wind up component (225) for minimizing wind up effects, and/or a filter sub-component (231) to ensure that the controller does not generate output signals to control the regulator in response to noise or erroneous signals.
90 Citations
32 Claims
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1. A drug delivery device for regulating delivery of a drug to a patient, the device comprising:
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a regulator for controllably varying the rate of delivery or dose of a drug passing to the patient; at least one sensor for measuring a biochemical, biological or physiological property of the patient, said property being associated with the drug to be delivered or with a condition to be treated by the drug to be delivered, and generating a signal corresponding to said measured property; a controller, in communication with the at least one sensor and the regulator, configured to control the rate of delivery or dose of the drug provided by the regulator in response to one or more measured biochemical, biological or physiological properties provided by the at least one sensor with respect to a target, the controller comprising a comparator having a signal input configured to receive an input signal from at least one sensor and being capable of generating an error signal corresponding to the disparity between a target value and an input signal; an active control component for generating an active output signal in response to the error signal; and a manipulation component for manipulating the active output signal and generating a post-manipulation signal for communication to the regulator as a final output signal, characterized in that; the controller further comprises an anti-wind up component for reducing or inhibiting the effect of signal wind up in the active control component; and
/orthe manipulation component comprises a filter sub-component for conditioning the active output signal, whereby the final output signal provides a controlled rate of delivery or dosage administered to a patient in response to the measured property. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 30)
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22-29. -29. (canceled)
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31. A method as claimed in claim 30, wherein the drug is oxygen, the sensor is a pulse oximeter and the device has a regulator, which is a valve.
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31-36. -36. (canceled)
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32. A method as claimed in claim 30, wherein the delivery means comprises tubing connected to an oxygen face mask or nasal cannula.
Specification