IMPLANTABLE CARDIAC DEVICE AND METHOD FOR MONITORING THE STATUS OF A CARDIOVASCULAR DISEASE
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Abstract
An implantable cardiac device has a heart stimulator for electrically stimulating the heart of a patient, detector that measures a physiologic parameter that is affected by the status of a cardiovascular disease associated with sympathetic activation, a signal processor that determines at least one of a low frequency, LF, and a very low frequency, VLF, Mayer wave component in the measured parameter, and analyzer that automatically analyzes the determined Mayer wave component in relation to a predetermined reference value to determine the status of the cardiovascular disease. The detector is a cardio-mechanical parameter detector that measures, as said physiologic parameter, a mechanical change in at least one of the four chambers of the heart. In a corresponding method for monitoring the status of a cardiovascular disease associated with sympathetic activation of a patient having an implantable electric heart stimulator a physiologic parameter affected by the cardiac disease is measured. At least one of a low frequency, LF, and a very low frequency, VLF, Mayer wave component in the parameter is determined, and the wave component is analyzed in relation to a predetermined reference value to determine the status of the cardiovascular disease. A mechanical change in at least one of the four chambers of the heart is measured as the physiologic parameter.
7 Citations
77 Claims
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1-37. -37. (canceled)
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38. An implantable cardiac device comprising:
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a cardio-mechanical parameter detector configured for in vivo placement in a living subject, that detects a physiologic parameter representing a mechanical change in at least one chamber of the heart of the subject that is affected by status of cardiovascular disease in the subject associated with sympathetic nerve activation, and that emits a detector output corresponding to said physiologic parameter; a housing configured for in vivo implantation in the subject; a processor in said housing and in communication with said cardio-mechanical detector to receive said detector output therefrom, that extracts a Mayer wave component, selected from the group consisting of a low frequency Mayer wave component and a very low frequency Mayer wave component, from said detector output; and an analyzer in said housing that compares the extracted Mayer wave component to a predetermined reference to obtain an analysis result indicative of said status of cardiovascular disease, said analyzer emitting an analyzer output signal corresponding to said analysis result. - View Dependent Claims (39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57)
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58. A method for monitoring status of cardiovascular disease, comprising the steps of:
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making an in vivo detection of a physiologic parameter in a subject representing a mechanical change in at least one chamber of the heart of the subject that is affected by status of cardiovascular disease in the subject associated with sympathetic nerve activation, and generating an electrical signal corresponding to said physiologic parameter; supplying said signal to a processor and, in said processor extracting a Mayer wave component, selected from the group consisting of a low frequency Mayer wave component and a very low frequency Mayer wave component; and automatically comparing the extracted Mayer wave component to a predetermined reference to obtain an analysis result indicative of said status of cardiovascular disease, and generating an analysis signal corresponding to said analysis result. - View Dependent Claims (59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77)
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Specification