Frozen compositions and methods for piercing a substrate

• US 20100121466A1
• Filed: 09/15/2009
• Published: 05/13/2010
• Est. Priority Date: 10/31/2008
• Status: Active Grant

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: Searete LLC (Intellectual Ventures LLC)
• Inventors: Myhrvold, Nathan P., Boyden, Edward S., Wood, Lowell L. JR., Hyde, Roderick A., Sweeney, Elizabeth A., Leuthardt, Eric C., Cook, Daniel B.
• Granted Patent: US 8,798,932 B2
• Time in Patent Office: Days
• US Class Current: 700/17
• CPC Class Codes: A61K 2039/505 comprising antibodies
• CPC Class Codes: A61K 2039/54 characterised by the route of administration
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/00 Medicinal preparations containing organic active ingredients
• CPC Class Codes: A61K 31/337 having four-membered rings, e.g. taxol
• CPC Class Codes: A61K 31/505 Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
• CPC Class Codes: A61K 31/519 ortho- or peri-condensed with heterocyclic rings
• CPC Class Codes: A61K 31/59 Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
• CPC Class Codes: A61K 31/70 Carbohydrates; Sugars; Derivatives thereof sorbitol A61K31/047
• CPC Class Codes: A61K 31/7088 Compounds having three or more nucleosides or nucleotides
• CPC Class Codes: A61K 31/74 Synthetic polymeric materials
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61K 38/38 Albumins
• CPC Class Codes: A61K 38/4833 Thrombin (3.4.21.5)
• CPC Class Codes: A61K 38/4886 Metalloendopeptidases (3.4.24), e.g. collagenase
• CPC Class Codes: A61K 39/00 Medicinal preparations containing antigens or antibodies materials for immunoassay G01N33/53
• CPC Class Codes: A61K 39/12 Viral antigens
• CPC Class Codes: A61K 39/145 Orthomyxoviridae, e.g. influenza virus
• CPC Class Codes: A61K 41/0004 Homeopathy; Vitalisation; Resonance; Dynamisation, e.g. esoteric applications; Oxygenation of blood
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 9/0019 : Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61K 9/0021 : Intradermal administration, e.g. through microneedle arrays, needleless injectors mechanical aspects A61M
• CPC Class Codes: A61K 9/007 : Pulmonary tract; Aromatherapy
• CPC Class Codes: A61K 9/08 : Solutions composition of solutions A61K47/00
• CPC Class Codes: A61K 9/12 : Aerosols; Foams A61K9/0043, A61K9/0056, A61K9/006, A61K9/0073 take precedence; spray-films A61K9/7015
• CPC Class Codes: A61K 9/143 : with inorganic compounds
• CPC Class Codes: A61K 9/1611 : Inorganic compounds
• CPC Class Codes: A61K 9/1641 : obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
• CPC Class Codes: A61K 9/1664 : Compounds of unknown constitution, e.g. material from plants or animals oils, fats, waxes, shellac A61K9/1617
• CPC Class Codes: A61K 9/1688 : resulting in pure drug agglomerate optionally containing up to 5% of excipient
• CPC Class Codes: A61K 9/19 : lyophilised , i.e. freeze-dried, solutions or dispersions lyophilised products with subsequent particle size reduction A61K9/14; granules or pellets made by lyphilisation A61K9/1682; solid oral dosage forms made by lyophilisation A61K9/2095; lyophilisation additives A61K47/00
• CPC Class Codes: A61K 9/209 : containing drug in at least two layers or in the core and in at least one outer layer
• CPC Class Codes: A61K 9/2095 : Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing mechanical aspects A61J3/00
• CPC Class Codes: A61K 9/2866 : Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
• CPC Class Codes: A61M 2037/0023 : Drug applicators using microneedles
• CPC Class Codes: A61M 2037/003 : having a lumen
• CPC Class Codes: A61M 2205/02 : characterised by a particular materials
• CPC Class Codes: A61M 37/0015 : by using microneedles
• CPC Class Codes: A61P 17/02 : for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 31/16 : for influenza or rhinoviruses
• CPC Class Codes: A61P 35/00 : Antineoplastic agents
• CPC Class Codes: B33Y 80/00 : Products made by additive manufacturing
• CPC Class Codes: C07K 16/22 : against growth factors ; against growth regulators
• CPC Class Codes: C07K 16/283 : against Fc-receptors, e.g. CD16, CD32, CD64 CD23 C07K16/2851
• CPC Class Codes: C07K 16/2842 : against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
• CPC Class Codes: C07K 16/2878 : against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
• CPC Class Codes: C07K 16/30 : from tumour cells
• CPC Class Codes: C12N 2760/16034 : Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
• CPC Class Codes: G16H 20/10 : relating to drugs or medications, e.g. for ensuring correct administration to patients
• CPC Class Codes: G16H 30/40 : for processing medical images, e.g. editing
• CPC Class Codes: G16H 50/20 : for computer-aided diagnosis, e.g. based on medical expert systems
• CPC Class Codes: G16H 50/50 : for simulation or modelling of medical disorders
• CPC Class Codes: Y02A 50/30 : Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
• CPC Class Codes: Y02A 90/10 : Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
• CPC Class Codes: Y10T 83/222 : With receptacle or support for cut product

Abstract

Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.

Claims

1. A system comprising:

at least one computing device;

one or more instructions that when executed on the at least one computing device cause the at least one computing device to receive a first input associated with a first possible dataset,

the first possible dataset including data representative of at least one parameter for making or administering at least one frozen particle composition or frozen piercing implement; and

one or more instructions that when executed generate an output to a user readable display.

2. The system of claim 1, further comprising one or more instructions that when executed on the at least one computing device cause the at least one computing device to compare a value associated with the first possible dataset with a second dataset including values of at least one predictive parameter for making the at least one frozen particle composition or frozen piercing implement.

3. The system of claim 1, further comprising one or more instructions that when executed on the at least one computing device cause the at least one computing device to determine a graphical illustration of the second possible dataset.

4. The system of claim 1, wherein the at least one parameter for making the at least one frozen particle composition or frozen piercing implement includes one or more of:

constitution of the at least one frozen particle composition or frozen piercing implement, formulation of the at least one frozen particle composition or frozen piercing implement, size of the at least one frozen particle composition or frozen piercing implement, density of the at least one frozen particle composition or frozen piercing implement, shape of the at least one frozen particle composition or frozen piercing implement, physical structure of the at least one frozen particle composition or frozen piercing implement, or physical or chemical integrity of the at least one frozen particle composition or frozen piercing implement.

5. The system of claim 1, wherein the at least one parameter for administering the at least one frozen particle composition or frozen piercing implement includes one or more of:

substrate type;

substrate function;

substrate size;

substrate constitution;

substrate architecture;

substrate durability;

substrate temperature;

temperature of administration conditions;

depth of administration of the at least one frozen particle composition or frozen piercing implement;

substrate source;

one or more temporal coordinates;

one or more spatial coordinates;

presence or absence of at least one agent;

presence or absence of at least one microparticle, nanoparticle, lens, tunablelens, sensor, transducer, actuator, detector, heater, valve, gate, channel, detection material, pump, power source, injector, controller, receiver, transmitter, or circuit;

angle of administration of the at least one frozen piercing implement device;

force of administration of the at least one frozen piercing implement device velocity of administration of the at least one frozen piercing implement device;

quantity of frozen piercing implements of the device;

quantity of frozen piercing implement devices administered;

rate of administration of more than one frozen piercing implement devices;

method of administration of at least one frozen piercing implement device;

timing of administration of at least one frozen piercing implement;

or rate of delivery of at least one agent of the device.

6. The system of claim 1, further comprising one or more instructions that when executed on the at least one computing device cause the at least one computing device to determine from the comparison at least one parameter for making or administering at least one frozen particle composition or frozen piercing implement to at least one substrate.

7. The system of claim 1, further comprising one or more instructions that when executed on the at least one computing device cause the at least one computing device to generate at least one response support structured on the determination.

8. The system of claim 1, further comprising one or more instructions that when executed on the at least one computing device cause the at least one computing device to access the first possible dataset in response to the first input.

9. The system of claim 1, further comprising one or more instructions that when executed on the at least one computing device cause the at least one computing device to generate the first possible dataset in response to the first input.

10. The system of claim 1, further comprising one or more instructions that when executed on the at least one computing device cause the at least one computing device to determine a graphical illustration of the first possible dataset.

11. The system of claim 1, wherein the at least one computing device includes one or more of a desktop computer, workstation computer, or computing system.

12. The system of claim 1, wherein the at least one computing system includes one or more of a cluster of processors, a networked computer, a tablet personal computer, a laptop computer, a mobile device, a mobile telephone, or a personal digital assistant computer.

13. The system of claim 1, wherein the output includes one or more instructions for making the at least one frozen particle composition or frozen piercing implement.

14. The system of claim 1, wherein the output includes at least one graphical description of the at least one frozen particle composition or frozen piercing implement.

15. The system of claim 1, wherein the user includes at least one entity.

16. The system of claim 15, wherein the entity includes at least one person, or computer.

21. The system of claim 1, wherein the user readable display includes one or more of a display of one or more differences in the comparison of at least one value related to the first input and at least one value related to at least one property of the at least one frozen particle composition or frozen piercing implement.

22. The system of claim 1, wherein the user readable display includes one or more of a display of one or more differences in the comparison of at least one value related to the second input and at least one value related to at least one parameter for administration of the at least one frozen particle composition or frozen piercing implement.

17-20. -20. (canceled)

23. A system comprising:

circuitry for accepting a first input associated with one or more parameters for making at least one frozen particle composition or frozen piercing implement;

circuitry for accepting a second input associated with one or more parameters for administering at least one frozen particle composition or frozen piercing implement to at least one substrate;

circuitry for processing the first input and the second input; and

circuitry for generating an output to a user readable display.

24. The system of claim 23, wherein the one or more parameters for making at least one frozen particle composition or frozen piercing implement include at least one value derived from an image.

30. The system of claim 23, further comprising circuitry for displaying results of the processing.

31. The system of claim 23, further comprising circuitry for transmitting one or more signals that include information related to the processing the first input and the second input.

34. The system of claim 23, wherein the output includes one or more instructions for making the at least one frozen particle composition or frozen piercing implement.

35. The system of claim 23, wherein the output includes at least one graphical description of the at least one frozen particle composition or frozen piercing implement.

36. The system of claim 23, wherein the user includes at least one entity.

37. The system of claim 36, wherein the entity includes at least one person, or computer.

42. The system of claim 23, wherein the user readable display includes one or more of a display of one or more differences in the comparison of at least one value related to the first input and at least one value related to at least one property of the at least one frozen particle composition or frozen piercing implement.

43. The system of claim 23, wherein the user readable display includes one or more of a display of one or more differences in the comparison of at least one value related to the second input and at least one value related to at least one parameter for administration of the at least one frozen particle composition or frozen piercing implement.

25-29. -29. (canceled)

32-33. -33. (canceled)

38-41. -41. (canceled)

44-62. -62. (canceled)

63. A system comprising:

a recordable medium bearing one or more instructions for accepting a first input associated with at least one parameter for making at least one frozen particle composition or frozen piercing implement;

one or more instructions for accepting a second input associated with at least one parameter for administering at least one frozen particle composition or frozen piercing implement;

one or more instructions for processing the first input and the second input; and

one or more instructions for generating an output to a user readable display.

64. The system of claim 63, wherein the recordable medium includes a computer-readable medium.

65. The system of claim 63, wherein the recordable medium includes a communications medium.

66. The system of claim 63, further comprising one or more instructions for transmitting one or more signals that include information related to the processing the first input and the second input.

71. The system of claim 63, wherein the output includes one or more instructions for making the at least one frozen particle composition or frozen piercing implement.

72. The system of claim 63, wherein the output includes at least one graphical description of the at least one frozen particle composition or frozen piercing implement.

73. The system of claim 63, wherein the user includes at least one entity.

74. The system of claim 73, wherein the entity includes at least one person, or computer.

79. The system of claim 63, wherein the user readable display includes one or more of a display of one or more differences in the comparison of at least one value related to the first input and at least one value related to at least one property of the at least one frozen particle composition or frozen piercing implement.

80. The system of claim 63, wherein the user readable display includes one or more of a display of one or more differences in the comparison of at least one value related to the second input and at least one value related to at least one parameter for administration of the at least one frozen particle composition or frozen piercing implement.

67-70. -70. (canceled)

75-78. -78. (canceled)

81-116. -116. (canceled)

117. A system comprising:

circuitry for accepting a first input associated with at least one parameter for making at least one frozen piercing implement device;

circuitry for accepting a second input associated with at least one parameter for administering at least one frozen piercing implement device to at least one substrate;

circuitry for processing the first input and the second input; and

circuitry for generating an output to a user readable display.

118. The system of claim 117, wherein the at least one frozen piercing implement device includes at least one frozen piercing implement array device, frozen piercing implement fluidic device, or frozen piercing implement injection device.

120. The system of claim 117, wherein the first input includes at least one value derived from at least one image.

125. The system of claim 117, wherein the at least one characteristic of the one or more frozen piercing implement device includes one or more of number of frozen piercing implements, number of total piercing implements, size of at least one frozen piercing implement, constitution of at least one frozen piercing implement, shape of at least one frozen piercing implement, shape of the device, configuration of the device, spacing of at least two components of the device, spacing of at least two frozen piercing implements of the device, or presence or absence of at least one microparticle, nanoparticle, lens, tunablelens, sensor, transducer, actuator, detector, heater, valve, gate, channel, detection material, pump, power source, injector, controller, receiver, transmitter, or circuit.

126. The system of claim 117, wherein the first input includes at least one parameter for making the at least one frozen piercing implement device includes one or more of:

constitution of the at least one frozen piercing implement of the frozen piercing implement device, constitution of the at least one frozen piercing implement device, configuration of the at least one frozen piercing implement or frozen piercing implement device, formulation of the at least one frozen piercing implement of the frozen piercing implement device, formulation of the at least one frozen piercing implement device, size of the at least one frozen piercing implement of the frozen piercing implement device, size of the at least one frozen piercing implement device, shape of the at least one frozen piercing implement of the frozen piercing implement device, shape of the at least one frozen piercing implement device, physical structure of the at least one frozen piercing implement of the frozen piercing implement device, physical structure of the at least one frozen piercing implement device, physical or chemical integrity of the at least one frozen piercing implement of the frozen piercing implement device, physical or chemical integrity of the at least one frozen piercing implement device, or presence or absence of at least one microparticle, nanoparticle, lens, tunablelens, sensor, transducer, actuator, detector, heater, valve, gate, channel, detection material, pump, power source, injector, controller, receiver, transmitter, or circuit, in the at least one frozen piercing implement or frozen piercing implement device.

127. The system of claim 117, wherein the second input includes at least one parameter for administering the at least one frozen piercing implement device includes one or more of:

substrate type;

substrate function;

substrate size;

substrate constitution;

substrate architecture;

substrate durability;

substrate temperature;

temperature of administration conditions;

depth of administration of the at least one frozen particle composition or frozen piercing implement;

substrate source;

one or more temporal coordinates;

one or more spatial coordinates;

presence or absence of at least one agent;

presence or absence of at least one microparticle, nanoparticle, lens, tunablelens, sensor, transducer, actuator, detector, heater, valve, gate, channel, detection material, pump, power source, injector, controller, receiver, transmitter, or circuit;

angle of administration of the at least one frozen piercing implement device;

force of administration of the at least one frozen piercing implement device;

velocity of administration of the at least one frozen piercing implement device;

quantity of frozen piercing implements of the device;

quantity of frozen piercing implement devices administered;

rate of administration of more than one frozen piercing implement devices;

method of administration of at least one frozen piercing implement device;

timing of administration of at least one frozen piercing implement;

or rate of delivery of at least one agent of the device.

128. The system of claim 117, further comprising circuitry for transmitting one or more signals that include information related to the processing the first input and the second input.

130. The system of claim 127, wherein the at least one agent includes at least one therapeutic agent, reinforcement agent, abrasive, explosive material, adhesive agent, or biological remodeling agent.

131. The system of claim 117, wherein the output includes one or more instructions for making the at least one frozen piercing implement device.

132. The system of claim 117, wherein the output includes at least one graphical description of the at least one frozen piercing implement device.

133. The system of claim 117, wherein the user includes at least one entity.

134. The system of claim 133, wherein the entity includes at least one person, or computer.

139. The system of claim 117, wherein the user readable display includes one or more of a display of one or more differences in the comparison of at least one value related to the first input and at least one value related to at least one property of the at least one frozen piercing implement device.

140. The system of claim 117, wherein the user readable display includes one or more of a display of one or more differences in the comparison of at least one value related to the second input and at least one value related to at least one parameter for administration of the at least one frozen piercing implement device.

119. (canceled)

121-124. -124. (canceled)

129. (canceled)

135-138. -138. (canceled)

141-201. -201. (canceled)