BASE SEQUENCE DETECTION APPARATUS AND BASE SEQUENCE AUTOMATIC ANALYZING APPARATUS
First Claim
1. An automatic base sequence analyzing apparatus for executing a measurement to analyze a base sequence of a sample by applying a voltage to a counter electrode of a base sequence detecting unit when the base sequence detecting unit is attached to the automatic base sequence analyzing apparatus,wherein the base sequence detecting unit includes a working electrode to which a probe having a predetermined base sequence is fixed, a reference electrode and the counter electrode, comprising:
- a voltage pattern generator which generates a voltage pattern to be applied to the counter electrode;
a feedback circuit which feeds a voltage of the reference electrode back to the counter electrode;
a first amplifier which amplifies a voltage generated on the basis of the voltage from the voltage pattern generator and the feedback circuit, and applies the amplified voltage to the counter electrode;
a first resistance arranged between input and output terminals of the first amplifier or between the first amplifier and the counter electrode;
a switch which ON/OFF-controls a current flowing into the first resistance;
a second amplifier connected to the working electrode; and
a second resistance arranged between input and output terminals of the second amplifier, which generates a voltage signal as a measurement signal which is output from the second amplifier.
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Accused Products
Abstract
A base sequence detection apparatus is provided with a channel formed on a base sequence detection chip. Working electrodes are formed along the channel and include a probe immobilized thereon, counter electrodes are formed on the inner surface of the channel and, reference electrodes are formed on the inner surface of the channel. An introduction port introduces solution or air from the upstream side of the channel, a delivery port delivers the solution or air in the channel, and the sample is injected into the channel through a sample injection port.
24 Citations
6 Claims
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1. An automatic base sequence analyzing apparatus for executing a measurement to analyze a base sequence of a sample by applying a voltage to a counter electrode of a base sequence detecting unit when the base sequence detecting unit is attached to the automatic base sequence analyzing apparatus,
wherein the base sequence detecting unit includes a working electrode to which a probe having a predetermined base sequence is fixed, a reference electrode and the counter electrode, comprising: -
a voltage pattern generator which generates a voltage pattern to be applied to the counter electrode; a feedback circuit which feeds a voltage of the reference electrode back to the counter electrode; a first amplifier which amplifies a voltage generated on the basis of the voltage from the voltage pattern generator and the feedback circuit, and applies the amplified voltage to the counter electrode; a first resistance arranged between input and output terminals of the first amplifier or between the first amplifier and the counter electrode; a switch which ON/OFF-controls a current flowing into the first resistance; a second amplifier connected to the working electrode; and a second resistance arranged between input and output terminals of the second amplifier, which generates a voltage signal as a measurement signal which is output from the second amplifier. - View Dependent Claims (2, 3, 4, 5, 6)
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Specification