Negative Pressure, Bi-Directional Nasal Aerosol Delivery

• US 20100122697A1
• Filed: 11/13/2009
• Published: 05/20/2010
• Est. Priority Date: 11/15/2008
• Status: Active Grant

• Current Assignee: CFD Research Corporation, Centers For Disease Control and Prevention (Government of the United States of America)
• Original Assignee: Centers For Disease Control and Prevention (Government of the United States of America)
• Inventors: Harrand, Vincent, Przekwas, Andrzej, Papania, Mark
• Granted Patent: US 8,191,552 B2
• Time in Patent Office: Days
• US Class Current: 128/200.210
• CPC Class Codes: A61M 15/0098 Activated by exhalation
• CPC Class Codes: A61M 15/08 Inhaling devices inserted into the nose
• CPC Class Codes: A61M 16/0009 with sub-atmospheric pressure, e.g. during expiration
• CPC Class Codes: A61M 16/0093 by adsorption, absorption or filtration
• CPC Class Codes: A61M 16/1055 bacterial
• CPC Class Codes: A61M 16/1065 in the expiratory path
• CPC Class Codes: A61M 2202/064 Powder
• CPC Class Codes: A61M 2210/0618 Nose
• CPC Class Codes: A61M 2210/0625 Mouth

Abstract

A method and apparatus for nasal drug delivery comprises a first tube in fluid communication with a means for generating a negative pressure and a second tube in fluid communication with an aerosol. The first tube is contacted with one nostril, the said second tube is contacted with the other nostril, and a negative pressure is applied to the first tube, producing a negative pressure within a nasal cavity and causing the aerosol to be drawn into the nasal passages and to deposit on an internal nasal surface.

Claims

1. A method for nasal delivery of an aerosol to a subject comprising the steps of:

contacting a first conduit with a first of two nasal nares, said first conduit being in fluid communication with a means for generating a negative pressure;

contacting a second conduit with a second of two nasal nares, said second conduit being in fluid communication with a source of aerosol; and

applying a negative pressure to the first conduit, thereby producing a negative pressure within a nasal cavity connecting the two nasal nares and causing the aerosol to be drawn into the first nasal nare and causing at least a portion of the aerosol to deposit on an internal nasal surface.

2. The method of claim 1, wherein the means for generating a negative pressure is selected from the group consisting of a vacuum pump, an air pump, a fan, a blower, and an aspirator.

3. The method of claim 1, wherein the source of aerosol is selected from the group consisting of a nebulizer, an atomizer, and a humidifier.

4. The method of claim 1, wherein the means for generating a negative pressure is regulated to control the negative pressure generated.

5. The method of claim 4, wherein the negative pressure is controlled to open or close an oropharyngeal vellum.

6. The method of claim 1, further comprising the step of placing an aperture into the second nasal nare.

7. The method of claim 6, wherein the aperture is configured to control the trajectory of aerosolized drug drawn into the second nasal nare.

8. The method of claim 6, wherein the aperture is configured to control a pressure gradient between the nasal cavity and a lumen of the second conduit.

9. The method of claim 1, wherein the first and/or second conduits are replaceable and disposable.

10. The method of claim 1, wherein the source of aerosol is a device activated by aerodynamic flow induced by the means for generating a negative pressure.

11. The method of claim 10, wherein the duration of applying a negative pressure to the first conduit is used to control the dose of aerosol delivered.

12. The method of claim 1, wherein the negative pressure applied to the first nasal nare is changed during the step of applying a negative pressure or a resistance to aerodynamic flow between the aerosol source and the first nasal nare is changed during the step of applying a negative pressure.

13. The method of claim 1, wherein the aerosol comprises a drug.

14. The method of claim 1, wherein said means for producing a negative pressure is powered by the subject'"'"'s breath.

15. An apparatus for delivering an aerosol to an internal nasal surface of a human or animal subject comprising:

means for producing a negative pressure in fluid communication with the distal end of a first conduit, said first conduit having a proximal end configured to form a seal with a first nasal nare of the subject; and

an aerosol source in fluid communication with the distal end of a second conduit, said second conduit having a proximal end configured to form a seal with a second nasal nare of the subject.

16. The apparatus of claim 15, wherein:

when the first and second conduits are configured such that, a negative pressure is produced within a nasal cavity of the subject when said means for producing a negative pressure is active, and

said negative pressure causes aerosol to be drawn into said second nostril from said aerosol source and at least a portion of said aerosol to be deposited on an internal nasal surface.

17. The apparatus of claim 15, further comprising an aerosol sensor configured to detect aerosol, and wherein said aerosol sensor is located between the first nasal nare and the means for producing a negative pressure.

18. The apparatus of claim 17, further comprising a control unit configured to control the negative pressure produced by the means for producing a negative pressure in response to a signal transmitted by the aerosol sensor.

19. The apparatus of claim 15, further comprising an aerosol filter configured to capture aerosol that is not deposited on an internal nasal surface, once the aerosol has exited the first nostril.

20. The apparatus of claim 15, wherein the means for producing a negative pressure is selected form the group consisting of a fan, an air pump, a vacuum pump, a blower, and an aspirator.

21. The apparatus of claim 15, wherein the source of aerosol is selected from the group consisting of a nebulizer, an atomizer, and a humidifier.

22. The apparatus of claim 15, wherein the first and second conduits are replaceable and disposable.

23. The apparatus of claim 15, and further comprising a valve configured to control the flow of aerosol into the second nasal nare.

24. The apparatus of claim 23, wherein the valve is located between the distal to the source of aerosol, between the source of aerosol and the second nasal nare, or between the source of negative pressure and the first nasal nare.

25. The apparatus of claim 15, wherein said means for producing a negative pressure is powered by the subject'"'"'s breath.