COLLECTION OF BIOMARKERS FOR DIAGNOSIS AND MONITORING OF ALZHEIMER'S DISEASE IN BODY FLUIDS
First Claim
Patent Images
1. A method of aiding diagnosis of Alzheimer'"'"'s disease (“
- AD”
), comprising comparing a measured level of at least sixteen AD diagnosis biomarkers in a biological fluid sample from an individual seeking a diagnosis for AD to a reference level for each biomarker, wherein the at least sixteen AD diagnosis biomarkers comprise;
MCSF (Macrophage Colony Stimulating Factor), RANTES, GCSF (granulocyte-colony stimulating factor), PARC (pulmonary and activation-regulated chemokine), ANG-2 (angiotensin-2), IL-11 (interleukin-11), EGF (epidermal growth factor), MCP-3 (monocyte chemoattractant protein-3), IL-3 (interleukin-3), MIP-1delta (macrophage inflammatory protein-1 delta), ICAM-1 (intercellular adhesion molecule
1), PDGF-BB (platelet-derived growth factor BB), IL-8 (interleukin
8), GDNF (glial derived neurotrophic factor), IL-1a (interleukin-1alpha), and TNF-a (tumor necrosis factor alpha).
4 Assignments
0 Petitions
Accused Products
Abstract
The inventors have discovered sets of proteinaceous biomarkers (“AD biomarkers”) which can be measured in peripheral biological fluid samples to aid in the diagnosis of neurodegenerative disorders, particularly Alzheimer'"'"'s disease. The invention further provides methods of identifying candidate agents for the treatment of Alzheimer'"'"'s disease by testing prospective agents for activity in modulating the levels of the AD biomarkers.
54 Citations
25 Claims
-
1. A method of aiding diagnosis of Alzheimer'"'"'s disease (“
- AD”
), comprising comparing a measured level of at least sixteen AD diagnosis biomarkers in a biological fluid sample from an individual seeking a diagnosis for AD to a reference level for each biomarker, wherein the at least sixteen AD diagnosis biomarkers comprise;
MCSF (Macrophage Colony Stimulating Factor), RANTES, GCSF (granulocyte-colony stimulating factor), PARC (pulmonary and activation-regulated chemokine), ANG-2 (angiotensin-2), IL-11 (interleukin-11), EGF (epidermal growth factor), MCP-3 (monocyte chemoattractant protein-3), IL-3 (interleukin-3), MIP-1delta (macrophage inflammatory protein-1 delta), ICAM-1 (intercellular adhesion molecule
1), PDGF-BB (platelet-derived growth factor BB), IL-8 (interleukin
8), GDNF (glial derived neurotrophic factor), IL-1a (interleukin-1alpha), and TNF-a (tumor necrosis factor alpha). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 24)
- AD”
-
23. A method for monitoring progression of Alzheimer'"'"'s disease (AD) in an AD patient, comprising:
- comparing a measured level of at least sixteen AD diagnosis biomarkers in a biological fluid sample from an individual seeking a diagnosis for AD to a reference level for each biomarker, wherein the at least sixteen AD diagnosis biomarkers comprise;
MCSF (Macrophage Colony Stimulating Factor), RANTES, GCSF (granulocyte-colony stimulating factor), PARC (pulmonary and activation-regulated chemokine), ANG-2 (angiotensin-2), IL-11 (interleukin-11), EGF (epidermal growth factor), MCP-3 (monocyte chemoattractant protein-3), IL-3 (interleukin-3), MIP-1delta (macrophage inflammatory protein-1 delta), ICAM-1 (intercellular adhesion molecule
1), PDGF-BB (platelet-derived growth factor BB), IL-8 (interleukin
8), GDNF (glial derived neurotrophic factor), IL-1a (interleukin-1alpha), and TNF-a (tumor necrosis factor alpha).
- comparing a measured level of at least sixteen AD diagnosis biomarkers in a biological fluid sample from an individual seeking a diagnosis for AD to a reference level for each biomarker, wherein the at least sixteen AD diagnosis biomarkers comprise;
-
25. A surface comprising attached thereto, at least one reagent specific for each of at least sixteen AD diagnosis biomarkers, said at least sixteen AD diagnosis biomarkers comprising:
- MCSF (Macrophage Colony Stimulating Factor), RANTES, GCSF (granulocyte-colony stimulating factor), PARC (pulmonary and activation-regulated chemokine), ANG-2 (angiotensin-2), IL-11 (interleukin-11), EGF (epidermal growth factor), MCP-3 (monocyte chemoattractant protein-3), IL-3 (interleukin-3), MIP-1delta (macrophage inflammatory protein-1 delta), ICAM-1 (intercellular adhesion molecule
1), PDGF-BB (platelet-derived growth factor BB), IL-8 (interleukin
8), GDNF (glial derived neurotrophic factor), IL-1a (interleukin-1alpha), and TNF-a (tumor necrosis factor alpha.
- MCSF (Macrophage Colony Stimulating Factor), RANTES, GCSF (granulocyte-colony stimulating factor), PARC (pulmonary and activation-regulated chemokine), ANG-2 (angiotensin-2), IL-11 (interleukin-11), EGF (epidermal growth factor), MCP-3 (monocyte chemoattractant protein-3), IL-3 (interleukin-3), MIP-1delta (macrophage inflammatory protein-1 delta), ICAM-1 (intercellular adhesion molecule
Specification