Prandial Blood Glucose Excursion Optimization Method Via Computation of Time-Varying Optimal Insulin Profiles and System Thereof
First Claim
1. A method for the computation of an optimal insulin infusion profile useful as a postprandial blood glucose control for a patient/meal combination, said method comprising:
- providing a pre-meal measurement of blood glucose concentration;
providing size and composition of a meal to be consumed;
providing pre-meal insulin infusion history,providing a chosen insulin pattern for the postprandial blood glucose control;
providing a dynamical model having model parameters which are predetermined for the patient/meal combination;
computing automatically the optimal insulin infusion profile by minimizing an objective function which is defined such that if two different insulin profiles are candidates to compensate for a patient/meal combination, the value of the objective function will be lower for the insulin profile which represents the best postprandial blood glucose control for this patient/meal combination, and said minimizing resulting in the optimal insulin infusion profile; and
providing the optimal insulin infusion profile.
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Abstract
A method and system for optimizing post prandial blood glucose excursions for persons with diabetes via computation of time-varying optimal insulin profiles are disclosed. The method builds upon a mathematical model based on the physiologic description of the human glucoregulatory system. Model parameter values are specific for each patient and meal type, and are determined from measured data by minimizing differences between both measurements and model predictions, and which are used to provide the optimal insulin profiles that are useful to diabetics in managing their chronic disease.
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Citations
20 Claims
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1. A method for the computation of an optimal insulin infusion profile useful as a postprandial blood glucose control for a patient/meal combination, said method comprising:
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providing a pre-meal measurement of blood glucose concentration; providing size and composition of a meal to be consumed; providing pre-meal insulin infusion history, providing a chosen insulin pattern for the postprandial blood glucose control; providing a dynamical model having model parameters which are predetermined for the patient/meal combination; computing automatically the optimal insulin infusion profile by minimizing an objective function which is defined such that if two different insulin profiles are candidates to compensate for a patient/meal combination, the value of the objective function will be lower for the insulin profile which represents the best postprandial blood glucose control for this patient/meal combination, and said minimizing resulting in the optimal insulin infusion profile; and providing the optimal insulin infusion profile. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A system which provides an optimal insulin infusion profile useful as a postprandial blood glucose control for a patient/meal combination, said system comprising:
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an input device configured to receive information about a pre-meal measurement of blood glucose concentration, and size and composition of a meal to be consumed; a memory which contains additional information about a pre-meal insulin infusion history, a chosen insulin pattern for the postprandial blood glucose control, and a dynamical minimal model having model parameters which are predetermined for the patient/meal combination; a processor programmed to use the received information and the additional information to compute automatically the optimal insulin infusion profile by minimizing an objective function, wherein said minimizing of the objective function results in the optimal insulin infusion profile; and a display configured to display the optimal insulin infusion profile.
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Specification