DEVICES AND METHODS FOR OPTIMIZING ELECTRODE PLACEMENT FOR ANTI-INFLAMATORY STIMULATION
First Claim
1. A method of optimizing the position of an electrode relative to a subject'"'"'s inflammatory reflex, the method comprising:
- implanting an electrode in electrical communication with either the vagus nerve, the splenic nerve, the hepatic nerve or the trigeminal nerve so the electrode can be stimulated to inhibit inflammation;
applying an electrical stimulus to electrode;
detecting a stimulation artifact;
determining an indicator of the power of the stimulation artifact;
adjusting the position of the position of the stimulation electrode based on the indicator of the power of the stimulation artifact.
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Accused Products
Abstract
Described herein are methods, devices and system for selecting an optimum position of a stimulation electrode, and particularly methods, devices and systems for optimizing the position of a stimulation electrode for stimulating the inflammatory reflex and thereby inhibiting inflammation. The methods, devices and systems described herein may generally include the analysis of one or more artifact modalities arising after the application of a stimulation pulse. One or more of these artifact modalities (e.g., EMG, ECG, etc.) may be detected and used to generate a comparable indicator of the fitness of the position of the electrode relative to a target, such as a portion of the inflammatory reflex like the vagus nerve.
170 Citations
14 Claims
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1. A method of optimizing the position of an electrode relative to a subject'"'"'s inflammatory reflex, the method comprising:
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implanting an electrode in electrical communication with either the vagus nerve, the splenic nerve, the hepatic nerve or the trigeminal nerve so the electrode can be stimulated to inhibit inflammation; applying an electrical stimulus to electrode; detecting a stimulation artifact; determining an indicator of the power of the stimulation artifact; adjusting the position of the position of the stimulation electrode based on the indicator of the power of the stimulation artifact. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A system for optimizing the position of an electrode relative to a subject'"'"'s inflammatory reflex, the system comprising:
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an electrode configured to apply stimulation and to detect electrical activity; a controller configured to apply a stimulation protocol, wherein the controller is adjustable so that the intensity, duration, and/or frequency of the stimulation may be adjusted; an analysis module configured to receive input from the electrode and the controller, and to detect a stimulation artifact, wherein the analysis module is further configured to remove the applied stimulation and filter the detected electrical activity; and an output configured to present an indicator of the power of the stimulation artifact. - View Dependent Claims (11, 12, 13, 14)
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Specification