Open platform automated sample processing system

• US 20100126286A1
• Filed: 10/09/2009
• Published: 05/27/2010
• Est. Priority Date: 04/06/2007
• Status: Active Grant

• Current Assignee: Becton, Dickinson & Co
• Original Assignee: QIAGEN Gaithersburg, Inc. (Qiagen NV)
• Inventors: Miller, Jonathan Matthew, Self, Brian Austin, Edens, Carl Theodore
• Granted Patent: US 8,703,492 B2
• Time in Patent Office: Days
• US Class Current: 73/863.810
• CPC Class Codes: G01N 2035/00524 Mixing by agitating sample carrier
• CPC Class Codes: G01N 2035/0405 manipulating closing or opening means, e.g. stoppers, screw caps, lids or covers
• CPC Class Codes: G01N 2035/041 lifting items out of a rack for access
• CPC Class Codes: G01N 35/026 having blocks or racks of reaction cells or cuvettes
• CPC Class Codes: G01N 35/04 Details of the conveyor system G01N35/021 - G01N35/028 take precedence
• CPC Class Codes: Y10T 436/11 Automated chemical analysis
• CPC Class Codes: Y10T 436/113332 with conveyance of sample along a test line in a container or rack
• CPC Class Codes: Y10T 436/114165 with step of insertion or removal from test line
• CPC Class Codes: Y10T 436/25 including sample preparation
• CPC Class Codes: Y10T 436/25125 Digestion or removing interfering materials
• CPC Class Codes: Y10T 436/2525 Stabilizing or preserving
• CPC Class Codes: Y10T 436/25375 Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
• CPC Class Codes: Y10T 436/255 including use of a solid sorbent, semipermeable membrane, or liquid extraction
• CPC Class Codes: Y10T 436/2575 Volumetric liquid transfer

Abstract

An automated sample processing system having a sample input adapted to simultaneously receive a number of sample containers, a reagent input adapted to receive one or more new reagent supplies, a consumable input adapted to receive one or more new consumable supplies, a solid waste output adapted to receive used consumable supplies, a liquid waste output adapted to receive one or more used reagent supplies, and a processing center. The processing center includes a decapper adapted to remove a lid from at least one sample container, an aspirator adapted to remove a specimen from the at least one sample container and transfer the specimen to an output vessel, and a capper adapted to replace the lid on the at least one sample container. The system also includes a sample output adapted to receive the output vessel, and a user interface adapted to receive an input from the user to indicate the identity of the at least one sample container, and control at least one operation based on a physical property of the at least one sample container.

Claims

1. (canceled)

2. A continuous-loading sample processing system comprising:

a sample input adapted to receive at least one sample container rack manually provided by a user;

a consumable input adapted to receive one or more unused consumable supplies manually provided by a user;

a waste output adapted to receive used consumable supplies;

an automated processing center comprising;

a decapper adapted to remove a lid from at least one sample container provided in the at least one sample container rack,

a pipettor adapted to remove a specimen from the at least one sample container and transfer the specimen to at least one output vessel, and

a capper adapted to replace the lid on the at least one sample container;

a sample output adapted to receive the at least one output vessel and present the at least one output vessel to a user for manual removal.

3. The system of claim 2, wherein the decapper and the capper comprise at least one combination decapper/capper unit adapted to remove the lid from the sample container and replace the lid on the sample container.

4. The system of claim 3, wherein the decapper and the capper comprise two combination decapper/capper units.

5. The system of claim 4, wherein the sample output comprises at least one output rack adapted to receive a plurality of output vessels.

6. The system of claim 2, wherein the automated processing center further comprises a transfer arm adapted to remove the at least one sample container from the sample container rack and place the at least one sample container in the decapper.

7. The system of claim 2, wherein the automated processing center further comprises at least one shaker adapted to shake the at least one sample container.

8. The system of claim 2, wherein the automated processing center further comprises:

at least one shaker adapted to shake the at least one sample container; and

a transfer arm system adapted to;

remove the at least one sample container from the at least one sample container rack and place the at least one sample container in the at least one shaker;

remove the at least one sample container from the at least one shaker and place the at least one sample container in the decapper; and

remove the at least one sample container from the capper and place the at least one sample container in the at least one sample container rack.

9. The system of claim 8, wherein the automated processing center further comprises a barcode reader adapted to read any readable barcode on the at least one sample container.

10. The system of claim 3, wherein the at least one combination decapper/capper comprises:

at least one bottle grip adapted to hold a bottle portion of the at least one sample container; and

at least one cap grip adapted to hold the lid;

wherein the bottle grip and the cap grip are movable relative to one another to remove the lid from the bottle portion.

11. The system of claim 10, wherein the at least one bottle grip comprises a bellows grip having a flexible bellows with a variable-size bore adapted to receive the bottle portion along an axis of the variable-size bore, and one or more ribs mounted on the flexible bellows within and aligned with the axis of the variable-size bore.

12. The system of claim 10, wherein the at least one bottle grip is mounted on a platform, the platform being adapted to selectively move to a first location accessible to the at least one cap grip, and a second location accessible to the pipettor, and further being adapted to tilt the bottle portion relative to a vertical axis at the second location.

13. The system of claim 2, wherein the at least one sample container rack comprises one or more sample holders adapted to hold at least one first sample container having a first size, and at least one second sample container having a second size that is different from the first size.

14. The system of claim 2, further comprising a reagent input adapted to receive one or more unused reagents manually provided by a user.

15. The system of claim 14, wherein the automated processing center further comprises at least one reagent dispenser adapted to dispense at least one of the one or more unused reagents into the at least one sample container.

16. A sample processing system comprising:

a sample input adapted to simultaneously receive a plurality of sample containers;

a consumable input adapted to receive one or more unused consumable supplies;

a waste output adapted to receive used consumable supplies;

an automated processing center comprising;

a decapper adapted to remove a lid from at least one sample container,

a pipettor adapted to remove a specimen from the at least one sample container and transfer the specimen to an output vessel, and

a capper adapted to replace the lid on the at least one sample container;

a sample output adapted to receive the output vessel; and

a user interface adapted to receive an input from the user to indicate the identity of the at least one sample container, and control at least one operation based on a physical property of the at least one sample container.

17. The system of claim 16, wherein the plurality of sample containers comprises at least one first sample container having a first size, and at least one second sample container having a second size that is different from the first size.

18. The system of claim 16, wherein the sample input is adapted to simultaneously receive a plurality of sample containers in a sample container rack.

19. The system of claim 16, wherein the sample container rack comprises one or more sample holders adapted to hold at least one first sample container having a first size, and at least one second sample container having a second size that is different from the first size.

20. The system of claim 16, further comprising a reagent input adapted to receive one or more unused reagents.

21. The system of claim 20, wherein the automated processing center further comprises at least one reagent dispenser adapted to dispense at least one of the one or more unused reagents into the at least one sample container.

22. A hybrid manual-automated method for processing samples, the method comprising:

manually providing a plurality of sample containers in a sample input;

manually providing unused consumable supplies in a consumables input;

automatically removing a lid from each sample container using an automated system;

automatically withdrawing a specimen from each sample container using the automated system;

automatically transferring the specimen to an output vessel using the automated system;

automatically replacing the lid on each sample container using the automated system;

automatically conveying the output vessel to an sample output location using the automated system; and

manually removing the output vessel from the sample output location.

23. The method of claim 22, further comprising programming the automated system to control at least one operation based on a physical property at least a first sample container.

24. The method of claim 23, wherein programming the automated system comprises manually programming the automated system.

25. The method of claim 22, further comprising programming the automated system to control at least one operation in a first manner based on a physical property at least a first sample container, and in a second manner based on a physical property of at least a second sample container.

26. The method of claim 22, wherein the plurality of sample containers comprise at least one first sample container having a first physical dimension and at least on second sample container having a second physical dimension that is different from the first physical dimension.

27. The method of claim 22, further comprising manually providing one or more unused reagent in a reagent input, and automatically dispensing at least one of the one or more unused reagents into at least one sample container.