DIRECT VESSEL HEATING FOR DISSOLUTION TESTING

• US 20100126980A1
• Filed: 11/24/2008
• Published: 05/27/2010
• Est. Priority Date: 11/24/2008
• Status: Abandoned Application

• Current Assignee: Agilent Technologies, Inc.
• Original Assignee: Agilent Technologies, Inc.
• Inventors: Fetvedt, Jeremy
• Application Number:
  US12/277,215
• Publication Number:
  US 20100126980A1
• Time in Patent Office: Days
• US Class Current: 219/441
• CPC Class Codes: G01N 13/00 Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects scanning-probe techniques or apparatus G01Q
• CPC Class Codes: G01N 2013/006 Dissolution of tablets or the like
• CPC Class Codes: G01N 33/15 Medicinal preparations ; Physical properties thereof, e.g. dissolubility drug screening with animal cells G01N33/5008
• CPC Class Codes: H05B 2203/002 Heaters using a particular layout for the resistive material or resistive elements
• CPC Class Codes: H05B 2203/005 using multiple resistive elements or resistive zones isolated from each other
• CPC Class Codes: H05B 2203/013 Heaters using resistive films or coatings
• CPC Class Codes: H05B 2203/016 Heaters using particular connecting means
• CPC Class Codes: H05B 3/28 heating conductor embedded in insulating material
• CPC Class Codes: Y10T 29/49826 Assembling or joining

Abstract

A dissolution test vessel configured for direct vessel heating includes a lateral wall, a resistive heating element, and a temperature-sensing element. The resistive heating element and the temperature-sensing element are bonded directly to the lateral wall, and may be formed by dispensing flowable materials onto the lateral wall. The resistive heating element includes a contiguous first heating element end, heating element section, and second heating element end. The temperature-sensing element includes a contiguous first sensing element end, sensing element section, and second sensing element end. The vessel may communicate with a heater control system, which may be provided with a dissolution test apparatus at which the vessel is mounted.

Claims

1. A dissolution test vessel configured for direct vessel heating, comprising:

a lateral wall disposed about a longitudinal axis of the vessel and comprising an upper end, a lower end axially spaced from the upper end, and an outside surface extending from the upper end to the lower end;

a resistive heating element bonded directly to the outside surface wherein the resistive heating element is integral with the lateral wall and non-removable therefrom, the resistive heating element comprising a first heating element end, a second heating element end, and a heating element section contiguously running from the first heating element end, over a heating zone of the lateral wall and to the second heating element end, the heating element section running along at least two different directions; and

a temperature-sensing element bonded directly to the outside surface wherein the temperature-sensing element is integral with the lateral wall and non-removable therefrom, the temperature-sensing element comprising a first sensing element end, a second sensing element end, and a sensing element section contiguously running from the first sensing element end, over a temperature sensing zone of the lateral wall and to the second sensing element end, the sensing element section running along at least two different directions.

2. The dissolution test vessel of claim 1, further comprising a clear film bonded directly to the outside surface and covering at least a portion of the resistive heating element and the temperature-sensing element

3. The dissolution test vessel of claim 1, further comprising a plurality of bond pads electrically connected to the respective first heating element end, the second heating element end, the first sensing element end, and the second sensing element end.

4. The dissolution test vessel of claim 1, further comprising an electrical contact element disposed at the upper end and comprising a first set of electrical contacts and a second set of electrical contacts, the first set of electrical contacts communicating with the respective first heating element end, the second heating element end, the first sensing element end, and the second sensing element end, and the second set of electrical contacts communicating with the first set of electrical contacts and configured for connection to a heater control circuit external to the dissolution test vessel.

5. The dissolution test vessel of claim 1, further comprising a flanged section disposed about the longitudinal axis and circumscribing the upper end, the flanged section comprising an electrical contact element, the electrical contact element comprising a first set of electrical contacts and a second set of electrical contacts, the first set of electrical contacts communicating with the respective first heating element end, the second heating element end, the first sensing element end, and the second sensing element end, and the second set of electrical contacts communicating with the first set of electrical contacts and configured for connection to a heater control circuit external to the dissolution test vessel.

6. The dissolution test vessel of claim 5, wherein the electrical contact element is removably attached to the flanged section.

7. The dissolution test vessel of claim 5, wherein the electrical contact element extends radially outward from an outermost diameter of the flanged section relative to the longitudinal axis.

8. The dissolution test vessel of claim 1, wherein the resistive heating element is a first resistive heating element, the heating element section is a first heating element section, and the heating zone is a first heating zone, and further comprising a second resistive heating element bonded directly to the outside surface and comprising a third heating element end, a fourth element end, and an elongated second heating element section contiguously running from the third heating element end, over a second heating zone of the lateral wall and to the fourth heating element end, the second heating element section running along at least two different directions.

9. The dissolution test vessel of claim 8, wherein the first heating zone is disposed axially above the second heating zone, and the temperature sensing zone is disposed at least partially within the second heating zone.

10. A dissolution test apparatus configured for direct vessel heating, comprising:

a vessel support member having an aperture;

a heater control system; and

a vessel mounted at the vessel support member, the vessel comprising;

a lateral wall disposed about a longitudinal axis of the vessel and comprising an upper end, a lower end axially spaced from the upper end, and an outside surface extending from the upper end to the lower end;

a resistive heating element bonded directly to the outside surface wherein the resistive heating element is integral with the lateral wall and non-removable therefrom, the resistive heating element comprising a first heating element end in signal communication with the heater control system, a second heating element end in signal communication with the heater control system, and an elongated heating element section contiguously running from the first heating element end, over a heating zone of the lateral wall and to the second heating element end, the heating element section running along at least two different directions; and

a temperature-sensing element bonded directly to the outside surface wherein the temperature-sensing element is integral with the lateral wall and non-removable therefrom, the temperature-sensing element comprising a first sensing element end in signal communication with the heater control system, a second sensing element end in signal communication with the heater control system, and an elongated sensing element section contiguously running from the first sensing element end, over a temperature sensing zone of the lateral wall and to the second sensing element end, the sensing element section running along at least two different directions.

11. The dissolution test apparatus of claim 10, further comprising a clear film bonded directly to the outside surface and covering at least a portion of the resistive heating element and the temperature-sensing element.

12. The dissolution test apparatus of claim 10, wherein the vessel further comprises an electrical contact element disposed at the upper end and comprising a first set of electrical contacts and a second set of electrical contacts, the first set of electrical contacts communicating with the respective first heating element end, the second heating element end, the first sensing element end, and the second sensing element end, and the second set of electrical contacts communicating with the first set of electrical contacts and with the heater control system.

13. The dissolution test apparatus of claim 10, wherein the vessel further comprises a flanged section disposed on the vessel support member and circumscribing the upper end, the vessel alignment ring comprising an electrical contact element, the electrical contact element comprising a first set of electrical contacts and a second set of electrical contacts, the first set of electrical contacts communicating with the respective first heating element end, the second heating element end, the first sensing element end, and the second sensing element end, and the second set of electrical contacts communicating with the first set of electrical contacts and with the heater control system.

14. The dissolution test apparatus of claim 13, wherein the vessel support member comprises a set of vessel support member electrical contacts in signal communication with the heater control system, and the second set of electrical contacts of the electrical contact element are removably connected to the respective vessel support member electrical contacts.

15. The dissolution test apparatus of claim 10, wherein the electrical contact element extends radially outward from an outermost diameter of the flanged section relative to the longitudinal axis and into a recess of the vessel support member.

16. The dissolution test apparatus of claim 10, wherein the vessel support member includes a plurality of apertures, the vessel is one of a plurality of vessels mounted at the respective apertures, each vessel includes a respective resistive heating element and a temperature-sensing element, and each resistive heating element and temperature-sensing element is in signal communication with the heater control system.

17. A method for fabricating a dissolution test vessel, the method comprising:

depositing a first flowable material directly on an outside surface of a lateral wall of a vessel to form a resistive heating element integral with and non-removable from the lateral wall, the resistive heating element comprising a first heating element end, a second heating element end, and an elongated heating element section contiguously running from the first heating element end, over a heating zone of the lateral wall and to the second heating element end, the heating element section running along at least two different directions;

depositing a second flowable material directly on the outside surface to form a temperature-sensing element integral with and non-removable from the lateral wall, the temperature-sensing element comprising a first sensing element end, a second sensing element end, and an elongated sensing element section contiguously running from the first sensing element end, over a temperature sensing zone of the lateral wall and to the second sensing element end, the sensing element section running along at least two different directions; and

attaching a contact block to an upper end of the vessel and placing the contact block in electrical communication with the resistive heating element and the temperature-sensing element.

18. The method of claim 17, further comprising applying a clear film directly to the outside surface wherein the film covers at least a portion of the resistive heating element and the temperature-sensing element.

19. The method of claim 17, wherein the first flowable material and the second flowable material are selected from the group consisting of conductive inks, resistive inks, conductive epoxies, and resistive epoxies.

20. The method of claim 17, further comprising attaching a flanged section to the upper end, wherein the contact block is attached to the flanged section.