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ANTIBODIES TO IL-6 AND USE THEREOF

  • US 20100129357A1
  • Filed: 07/14/2009
  • Published: 05/27/2010
  • Est. Priority Date: 11/25/2008
  • Status: Active Grant
First Claim
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1. A method of preventing, treating, or diagnosing a disease or condition associated with IL-6, comprising administration of an Ab1 antibody or antibody fragment to a subject in need thereof, wherein the Ab1 antibody or antibody fragment comprises:

  • a light chain polypeptide selected from the group consisting of;

    a polypeptide having at least 75% identity to SEQ ID NO;

    699, a polypeptide encoded by a polynucleotide that has at least 75% identity to the polynucleotide of SEQ ID NO;

    698, a polypeptide encoded by a polynucleotide that hybridizes under medium stringency conditions to a polynucleotide having the sequence of the reverse complement of SEQ ID NO;

    698, and a polypeptide encoded by a polynucleotide that hybridizes under high stringency conditions to a polynucleotide having the sequence of the reverse complement of SEQ ID NO;

    698; and

    a heavy chain polypeptide selected from the group consisting of;

    a polypeptide having at least 75% identity to SEQ ID NO;

    657, a polypeptide encoded by a polynucleotide that has at least 75% identity to the polynucleotide of SEQ ID NO;

    700, a polypeptide encoded by a polynucleotide that hybridizes under medium stringency conditions to a polynucleotide having the sequence of the reverse complement of SEQ ID NO;

    700, and a polypeptide encoded by a polynucleotide that hybridizes under high stringency conditions to a polynucleotide having the sequence of the reverse complement of SEQ ID NO;

    700;

    wherein the Ab1 antibody or antibody fragment specifically binds to IL-6 and antagonizes one or more activity associated with IL-6.

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