Targeting of Antigen Presenting Cells with Immunonanotherapeutics
First Claim
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1. A composition comprising:
- (1) synthetic nanocarriers having at least one surface, wherein a first surface of the synthetic nanocarriers comprises an immunofeature surface; and
(2) a pharmaceutically acceptable excipient.
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Abstract
The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface. The nanocarriers are capable of targeting antigen presenting cells when administered to a subject. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.
212 Citations
25 Claims
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1. A composition comprising:
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(1) synthetic nanocarriers having at least one surface, wherein a first surface of the synthetic nanocarriers comprises an immunofeature surface; and (2) a pharmaceutically acceptable excipient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. A method for increasing the uptake of an antigen by a subcapsular sinus macrophage, comprising administering to a subject in need thereof a composition comprising:
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(1) a synthetic nanocarrier comprising; (a) at least one surface, wherein a first surface of the synthetic nanocarrier comprises an immunofeature surface; and (b) an antigen, wherein the antigen is on;
(i) the immunofeature surface;
(ii) a second surface of the nanocarrier;
or (iii) encapsulated within a core region of the nanocarrier; and(2) a pharmaceutically acceptable excipient - View Dependent Claims (23, 24, 25)
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Specification