Contact drug delivery system

• US 20100129424A9
• Filed: 02/03/2006
• Published: 05/27/2010
• Est. Priority Date: 02/04/2005
• Status: Active Grant

• Current Assignee: Auburn University
• Original Assignee: Auburn University
• Inventors: Byrne, Mark, Venkatesh, Siddarth
• Granted Patent: US 8,349,351 B2
• Time in Patent Office: Days
• US Class Current: 424/427
• CPC Class Codes: A61K 9/0051 Ocular inserts, ocular implants
• CPC Class Codes: A61L 2300/402 Anaestetics, analgesics, e.g. lidocaine
• CPC Class Codes: A61L 2300/406 Antibiotics
• CPC Class Codes: A61L 2300/41 Anti-inflammatory agents, e.g. NSAIDs
• CPC Class Codes: A61L 2300/416 Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
• CPC Class Codes: A61L 2300/426 Immunomodulating agents, i.e. cytokines, interleukins, interferons
• CPC Class Codes: A61L 2300/452 Lubricants
• CPC Class Codes: A61L 2300/602 Type of release, e.g. controlled, sustained, slow
• CPC Class Codes: A61L 27/52 Hydrogels or hydrocolloids
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: A61P 27/06 Antiglaucoma agents or miotics
• CPC Class Codes: A61P 27/14 Decongestants or antiallergics
• CPC Class Codes: A61P 3/04 Anorexiants; Antiobesity agents
• CPC Class Codes: B29K 2105/0035 Medical or pharmaceutical agents
• CPC Class Codes: B29L 2011/0041 Contact lenses
• CPC Class Codes: G02B 1/043 Contact lenses

Abstract

A drug delivery system is disclosed. The drug delivery system includes a recognitive polymeric hydrogel through which a drug is delivered by contacting biological tissue. The recognitive polymeric hydrogel is formed using a bio-template, which is a drug or is structurally similar to the drug, functionalized monomers, preferably having coamplexing sites, and cross-linking monomers, which are copolymerized using a suitable initiator. The complexing sites of the recognitive polymeric hydrogel that is formed preferably mimics receptor sites of a target biological tissue, biological recognition, or biological mechanism of action. The system in accordance with an embodiment of the intention is a contact lens for delivering a drug through contact with an eye.

Claims

1. A method for making a drug delivery system, the method comprising:

a) forming a recognitive polymeric hydrogel; and

b) forming a recognitive polymeric hydrogel into contact lenses.

2. The method of claim 1, wherein forming a recognitive polymeric hydrogel comprises forming a solution comprising amounts of a bio-template, a functionalized monomer cross-linking monomer and initiating copolymerization of the functionalized monomer and cross-linking monomer.

4. The method of claim 2, further comprising washing a portion of the bio-template from the recognitive polymeric hydrogel and loading the recognitive polymeric hydrogel with a drug.

5. The method of claim 4, wherein the drug is selected from the group consisting of an antibiotic, an anti-inflammatory, an antihistamine, an antiviral agent, a cancer drug, an anesthetic, a cycloplegic, a mydriatics, a lubricant agent, a hydrophilic agent, a decongestant, a vasoconstrictor, vasodilater, an Immuno-suppressant, an immuno-modulating agent and an anti-glaucoma agent.

6. The method of claim 2, further comprising washing a portion of the bio-template from the contact lenses and loading the contact lenses with a drug by soaking the contact lenses in an aqueous drug solution.

7. The method of claim 6, wherein the drug a drug selected from the group consisting of an antibiotic, an anti-inflammatory, an antihistamine, an antiviral agent, a cancer drug, an anesthetic, a cycloplegic, a mydriatics, a lubricant agent, a hydrophilic agent, a decongestant, a vasoconstrictor, vasodilater, an Immuno-suppressant, an immuno-modulating agent and an anti-glaucoma agent.

8. The method of claim 2, wherein the bio-template is a drug.

9. The method of claim 8, wherein the drug is selected from the group consisting of an antibiotic, an anti-inflammatory, an antihistamine, an antiviral agent, a cancer drug, an anesthetic, a cycloplegic, a mydriatics, a lubricant agent, a hydrophilic agent, a decongestant, a vasoconstrictor, vasodilater, an Immuno-suppressant, an immuno-modulating agent and an anti-glaucoma agent.

10. The method of claim 2, further comprising identifying molecules associated with a target biological tissue and synthesizing the functionalized monomer with functional groups that are structurally similar the molecules.

11. A method of dispensing a drug comprising:

a) forming a recognitive polymeric hydrogel matrix impregnated with a drug; and

b) placing the recognitive polymeric hydrogel is contact with a biological tissue to dispense the drug.

12. The method of claim 11, wherein the drug is selected from the group consisting of an antibiotic, an anti-inflammatory, an antihistamine, an antiviral agent, a cancer drug, an anesthetic, a cycloplegic, a mydriatics, a lubricant agent, a hydrophilic agent, a decongestant, a vasoconstrictor, vasodilater, an Immuno-suppressant, an immuno-modulating agent and an anti-glaucoma agent.

13. The method of claim 11, wherein forming the recognitive polymeric hydrogel matrix comprises generating a solution comprising amounts of a bio-template, a functionalized monomer cross-linking monomer and initiating co-polymerization of the functionalized monomer and cross-linking monomer.

14. The method of claim 13, wherein forming the recognitive polymeric hydrogel matrix is a contact lens.

15. The method of claim 13, wherein the bio-template is a drug.

16. The method of claim 15, wherein the drug is selected from the group consisting of an antibiotic, an anti-inflammatory, an antihistamine, an antiviral agent, a cancer drug, an anesthetic, a cycloplegic, a mydriatics, vasodilater, a lubricant agent, a hydrophilic agent, a decongestant, a vasoconstrictor, an immuno-suppressant, an immuno-modulating agent and an anti-glaucoma agent.

17. The method of claim 11, further comprising reloading the recognitive polymeric hydrogel matrix with the drug by soaking the recognitive polymeric hydrogel matrix in an aqueous solution of the drug.

18. A drug delivery system comprising a contact lens, the contact lens comprising a hydrogel matrix with complexing sites that complex a drug and release the drug from the hydrogel matrix over time while in contact with a surface of an eye.

19. The drug delivery system of claim 18, wherein the hydrogel matrix comprises silicon-base polymer chains.

20. The drug delivery system of claim 18, wherein the complexing sites comprise amino acid functional groups.

21. The drug delivery system of claim 18, wherein the group consisting of an antibiotic, an anti-inflammatory, an antihistamine, an antiviral agent, a cancer drug, an anesthetic, a cycloplegic, a mydriatics, a lubricant agent, a hydrophilic agent, a decongestant, a vasoconstrictor, vasodilater, an Immuno-suppressant, an immuno-modulating agent and an anti-glaucoma agent.

22. The drug delivery system of claim 18, wherein the drug is Ketotifen.