Adjuvant Incorporation in Immunonanotherapeutics
First Claim
Patent Images
1. A composition comprising:
- (1) synthetic nanocarriers having a least one surface, wherein a first surface of the synthetic nanocarriers comprises an immunofeature surface;
(2) an immunostimulatory agent;
(3) an MHC Class I, MHC Class II or CD1 presentable polypeptide; and
(4) a pharmaceutically acceptable excipient.
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Abstract
The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface and an immunostimulatory moiety. In some embodiments, the immunostimulatory moiety is an adjuvant. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.
207 Citations
29 Claims
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1. A composition comprising:
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(1) synthetic nanocarriers having a least one surface, wherein a first surface of the synthetic nanocarriers comprises an immunofeature surface; (2) an immunostimulatory agent; (3) an MHC Class I, MHC Class II or CD1 presentable polypeptide; and (4) a pharmaceutically acceptable excipient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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Specification