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GASTRORETENTIVE SYSTEM COMPRISING AN ALGINATE BODY

  • US 20100129445A1
  • Filed: 05/27/2008
  • Published: 05/27/2010
  • Est. Priority Date: 06/04/2007
  • Status: Abandoned Application
First Claim
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1. A gastroretentive system for the controlled, continuous release of active pharmaceutical ingredients in the stomach, comprising:

  • at least one release device for at least one active pharmaceutical ingredient; and

    at least one swelling body that is connected to said at least one release device,said at least one release device being an osmotic system comprising a chamber and an active pharmaceutical ingredient-containing core, an osmotically active substance in addition to the at least one active pharmaceutical ingredient, a semipermeable membrane surrounding said chamber and said core, said semipermeable membrane forming the wall of said chamber and comprising at least one outlet opening for the active pharmaceutical ingredient, and wherein said osmotic system further comprises design features for preventing direct or close contact of the outlet opening with the mucous membrane of the stomach;

    orsaid at least one release device being an osmotic system comprising at least two chambers within a common covering and wherein the at least one active pharmaceutical ingredient and the osmotically active substance are present in separate chambers within said common covering, and wherein the boundary of the active pharmaceutical ingredient-containing chamber is flexible at least in an area, the chamber that contains the osmotically active substance not having an opening, the chamber that contains the at least one active pharmaceutical ingredient preparation having an opening for the escape of the at least one active pharmaceutical ingredient, which opening leads outwards and penetrates said common covering, wherein after the administration of the gastroretentive system with a liquid which enters the chamber with the osmotically active substance leads to an increase in the volume of said chamber for the osmotically active substance for pushing the active pharmaceutical ingredient preparation out of said chamber for said the active pharmaceutical ingredient through the opening;

    orwherein said gastroretentive system comprises as a press-coated tablet comprising at least one swelling body and a tablet core, wherein the at least one swelling body forms a coating layer surrounding the tablet core of the press-coated tablet, said tablet core comprising an erodible mass containing at least one active pharmaceutical ingredient, and the coating layer, surrounding the tablet core having an opening for allowing the at least one active pharmaceutical ingredient to escape.

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