Flexible Bioreactor

• US 20100129899A1
• Filed: 12/16/2009
• Published: 05/27/2010
• Est. Priority Date: 06/15/2007
• Status: Abandoned Application

• Current Assignee: Strix Beheer B.V.
• Original Assignee: CELLution BioTech B.V.
• Inventors: van der Heiden, Pieter, Oosterhuis, Nicolaas Marius Gerard, Peeters, Marc Alfons Eugeen
• Application Number:
  US12/639,434
• Publication Number:
  US 20100129899A1
• Time in Patent Office: Days
• US Class Current: 435/288.700
• CPC Class Codes: B01F 31/23 by pivoting the containers about an axis
• CPC Class Codes: B01F 35/51 characterised by their material
• CPC Class Codes: B01F 35/513 Flexible receptacles, e.g. bags supported by rigid containers
• CPC Class Codes: C12M 23/00 Constructional details, e.g. recesses, hinges flow directing inserts in C12M27/18-C12M27/24; apparatus for chemical or physical processes in general B01J, chemical or physical laboratory apparatus in general B01L
• CPC Class Codes: C12M 23/14 Bags
• CPC Class Codes: C12M 23/48 Holding appliances; Racks; Supports holding devices for laboratory apparatus B01L9/00
• CPC Class Codes: C12M 29/04 Filters; Permeable or porous membranes or plates, e.g. dialysis
• CPC Class Codes: C12M 41/46 of cellular or enzymatic activity or functionality, e.g. cell viability

Abstract

A flexible bioreactor intended for culturing cells in a liquid medium, the bioreactor comprising a flexible wall forming a fluid impermeable bottom wall of the bioreactor when in use, wherein flexible parts of said flexible bottom wall are interrupted by at least one rigid element of said flexible bottom wall, the rigid element and the flexible parts being connected fluid tightly, and wherein the rigid element comprises measuring means allowing for non-invasive monitoring of cellular activity in said bioreactor when in use.

Claims

2-1. Bioreactor according to claim 1, wherein the rigid element comprises a coupling element that is sealingly connected to the flexible parts of the bottom wall to form a fluid tight connection therewith, and wherein the rigid element further comprises an insert element that is sealingly connected to the coupling element to form a fluid tight connection therewith.