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Method and system for sequencing polynucleotides

  • US 20100130368A1
  • Filed: 08/24/2009
  • Published: 05/27/2010
  • Est. Priority Date: 07/30/1998
  • Status: Abandoned Application
First Claim
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1. A method of determining a sequence of a target polynucleotide comprisinga) providing a device comprising an array of relatively short polynucleotides and relatively long polynucleotides immobilised on a surface of a solid support, wherein the relatively long polynucleotides are fragments of the target polynucleotide and wherein the relatively long polynucleotides are separated by a distance of at least 10 nm, whereby parts of the relatively long polynucleotides that extend beyond the relatively short polynucleotides can be individually optically resolved;

  • andb) determining the sequence of the target polynucleotide by detecting incorporation of nucleotides into strands complementary to the relatively long polynucleotide fragments using fluorescent labels associated with the incorporated nucleotides.

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