DNA-PKCS MODULATES ENERGY REGULATION AND BRAIN FUNCTION
First Claim
1. A method of inhibiting DNA-PKcs expression and/or activity in a mammal to increase mitochondrial numbers, to increase thermogenesis, to increase insulin sensitivity, to improve insulin signaling, to reduce blood glucose levels, to increase AMPK and PGC-1 alpha activities, to improve motor function, to improve memory and learning abilities, to reduce depression and anxiety, to reduce inflammatory signaling, and/or to increase Sirt1, eNOS, VEGF and BDNF expression, the method comprisingadministering to the mammal a therapeutically effective amount of an inhibitor of DNA-PKcs activityto reduce weight in the mammal, to increase mitochondrial numbers, to increase thermogenesis, to increase insulin sensitivity, to improve insulin signaling, to reduce blood glucose levels, to increase AMPK and PGC-1 alpha activities, to improve motor function, to improve memory and learning abilities, to reduce depression and anxiety, to reduce inflammatory signaling and/or to increase Sirt1, eNOS, VEGF and BDNF expression in the mammal.
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Abstract
The invention relates to new functions of the DNA-PKcs gene product in energy metabolism, brain function and physical fitness.
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Citations
61 Claims
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1. A method of inhibiting DNA-PKcs expression and/or activity in a mammal to increase mitochondrial numbers, to increase thermogenesis, to increase insulin sensitivity, to improve insulin signaling, to reduce blood glucose levels, to increase AMPK and PGC-1 alpha activities, to improve motor function, to improve memory and learning abilities, to reduce depression and anxiety, to reduce inflammatory signaling, and/or to increase Sirt1, eNOS, VEGF and BDNF expression, the method comprising
administering to the mammal a therapeutically effective amount of an inhibitor of DNA-PKcs activity to reduce weight in the mammal, to increase mitochondrial numbers, to increase thermogenesis, to increase insulin sensitivity, to improve insulin signaling, to reduce blood glucose levels, to increase AMPK and PGC-1 alpha activities, to improve motor function, to improve memory and learning abilities, to reduce depression and anxiety, to reduce inflammatory signaling and/or to increase Sirt1, eNOS, VEGF and BDNF expression in the mammal.
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9. The method of claim 9, wherein the serum triglycerides and/or serum leptin levels are reduced by about 5% to about 70% in the mammal relative to a control mammal that does not receive the inhibitor.
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26. The method of claim 26, wherein insulin levels are lower in the mammal by about 10% to about 50% relative to a control mammal that does not receive the inhibitor.
Specification