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DNA-PKCS MODULATES ENERGY REGULATION AND BRAIN FUNCTION

  • US 20100130597A1
  • Filed: 07/03/2008
  • Published: 05/27/2010
  • Est. Priority Date: 07/06/2007
  • Status: Abandoned Application
First Claim
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1. A method of inhibiting DNA-PKcs expression and/or activity in a mammal to increase mitochondrial numbers, to increase thermogenesis, to increase insulin sensitivity, to improve insulin signaling, to reduce blood glucose levels, to increase AMPK and PGC-1 alpha activities, to improve motor function, to improve memory and learning abilities, to reduce depression and anxiety, to reduce inflammatory signaling, and/or to increase Sirt1, eNOS, VEGF and BDNF expression, the method comprisingadministering to the mammal a therapeutically effective amount of an inhibitor of DNA-PKcs activityto reduce weight in the mammal, to increase mitochondrial numbers, to increase thermogenesis, to increase insulin sensitivity, to improve insulin signaling, to reduce blood glucose levels, to increase AMPK and PGC-1 alpha activities, to improve motor function, to improve memory and learning abilities, to reduce depression and anxiety, to reduce inflammatory signaling and/or to increase Sirt1, eNOS, VEGF and BDNF expression in the mammal.

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