APPARATUS AND METHODS FOR MONITORING BLOOD FLOW IN THE PROSTRATE GLAND

• US 20100130880A1
• Filed: 04/16/2008
• Published: 05/27/2010
• Est. Priority Date: 04/16/2007
• Status: Abandoned Application

• Current Assignee: Hegln (Dalian) Pharmaceuticals, Inc.
• Original Assignee: Urodynamix Technologies Ltd.
• Inventors: Li, Luya
• Application Number:
  US12/595,338
• Publication Number:
  US 20100130880A1
• Time in Patent Office: Days
• US Class Current: 600/504
• CPC Class Codes: A61B 18/18 by applying electromagnetic radiation, e.g. microwaves radiation therapy A61N5/00
• CPC Class Codes: A61B 2018/1807 using light other than laser radiation
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/0086 using infrared radiation
• CPC Class Codes: A61B 5/0261 using optical means, e.g. infrared light
• CPC Class Codes: A61B 5/0507 using microwaves or terahertz waves
• CPC Class Codes: A61B 5/4381 Prostate evaluation or disorder diagnosis
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: A61B 8/12 in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00

Abstract

A system for detecting blood flow in the prostate comprises a blood flow sensor disposed on a catheter that can be inserted into a subject'"'"'s urethra so that the blood flow sensor is located to detect blood flow in the subject'"'"'s prostate gland. The sensor may be a sensor of a near infrared spectroscopy (NIRS) system configured to detect in the prostate one or more biocompounds indicative of blood flow. An output of the sensor may provide an input to a controller for a heater disposed to heat tissues of the prostate. Some embodiments comprise one or more additional sensors for detecting blood flow and/or temperature of a portion of the subject'"'"'s rectal wall adjacent to the prostate gland. In such embodiments, outputs from the additional sensors may provide additional inputs to the controller.

Claims

1. A system for measuring blood flow in a subject'"'"'s prostate gland, the system comprising:

a catheter sized and configured such that, when placed within the urinary tract of a male individual, a proximal portion of the catheter resides outside the body of the individual, a middle portion of the catheter resides within a urethra of the individual and a distal portion of the catheter comprising an anchor resides within a urinary bladder of the individual; and

,

a blood flow sensor supported by the middle portion of the catheter at a location spaced apart from the anchor.

2. A system according to claim 1 wherein the blood flow sensor comprises at least one near infrared light source and at least one near infrared light detector.

3. A system according to claim 2 wherein the near infrared light source comprises a light-emitting area of a first optical fiber extending along the catheter from the proximal portion to the middle portion and having a light emitter configured to direct light into the optical fiber at a proximal end thereof.

4. A system according to claim 3 wherein the near infrared light detector comprises a light-capturing area of a second optical fiber extending along the catheter from the proximal portion to the middle portion.

5. A system according to claim 4 wherein the first and second optical fibers are coaxial.

6. A system according to claim 5 wherein the first and second optical fibers are slidable relative to one another so as to permit varying a separation between the light-emitting area of the first optical fiber and the light-capturing area of the second optical fiber.

7. A system according to claim 2 wherein the at least one near infrared light detector of the blood flow sensor comprises a plurality of near infrared light detectors spaced apart from one another along the catheter.

8. A system according to claim 7 wherein the at least one near infrared light detector of the blood flow sensor comprises a plurality of near infrared light detectors oriented to detect light incident on the near infrared light detectors from a corresponding plurality of different directions.

9. A system according to claim 2 wherein the at least one near infrared light source and at least one near infrared light detector are arranged to provide a plurality of light-source-detector pairs wherein, in different ones of the light-source-detector pairs corresponding ones of the light sources and light detectors are spaced apart from one another by different distances.

10. A system according to claim 2 wherein the at least one near infrared light source is configured to emit light in a plurality of radial directions relative to the catheter.

11. A system according to claim 10 wherein the at least one near infrared light detector comprises a plurality of near infrared light detectors oriented to detect light incident on the catheter from different radial directions.

12. A system according to claim 2 wherein the catheter comprises a lumen having transparent walls and the at least one near infrared light source and the at least one near infrared light detector are located within the lumen.

13. A system according to claim 2 comprising a near infrared spectroscopy system configured to determine, based at least in part on an output of the near infrared light detector, a value indicative of a concentration of at least one bio compound related to blood flow.

14. A system according to claim 13 wherein the at least one bio compound comprises one or more of oxygenated hemoglobin;

non-oxygenated hemoglobin;

total hemoglobin; and

myoglobin.

15. A system according to claim 2 comprising an opaque barrier between the at least one near infrared light source and at least one near infrared light detector.

16. A system according to claim 15 wherein the opaque barrier has a labyrinth structure and is apertured to permit fluid flow past the opaque barrier.

17. A system according to claim 1 comprising a microwave antenna supported in or on the catheter.

18. A system according to claim 1 comprising a heater for heating the subject'"'"'s prostate gland and a heater controller connected to control operation of the heater based at least in part on an output of the blood flow sensor.

19. A system according to claim 18 wherein the controller is configured to detect a peak in a blood flow in the subject'"'"'s prostate based on the output of the blood flow sensor.

20. A system according to claim 19 wherein the controller is configured to determine the end of a predetermined interval after detecting the peak in the blood flow in the subject'"'"'s prostate.

21. A system according to claim 20 wherein the controller is configured to discontinue operation of the heater at the end of the predetermined time.

22. A system according to claim 19 wherein the controller is configured to discontinue operation of the heater upon detecting the peak.

23. A system according to claim 19 wherein the controller is configured to discontinue operation of the heater upon the output of the blood flow sensor falling to below a threshold value.

24. A system according to claim 18 comprising a rectal probe, the rectal probe comprising a temperature sensor.

25. A system according to claim 18 comprising a rectal probe, the rectal probe comprising a rectal wall blood flow sensor.

26. A system according claim 25 wherein the rectal wall blood flow sensor comprises a near infrared spectroscopy sensor.

27. A system according to claim 26 wherein the near infrared spectroscopy sensor comprises a plurality of pairs of near infrared light sources and corresponding near infrared light detectors.

28. A system according to claim 26 wherein the near infrared spectroscopy sensor comprises a light source and a plurality of different light detectors spaced apart from the light source by different distances.

29. A system according claim 25 wherein the rectal wall blood flow sensor comprises an ultrasound-based blood-flow detector.

30. A system according claim 25 wherein the rectal wall blood flow sensor comprises a skin impedance detector.

31. A system according to claim 25 wherein the rectal probe comprises a temperature sensor.

32. A system according to claim 25 wherein the controller is configured to detect a peak in a signal derived from an output of the rectal wall blood flow sensor.

33. A system according to claim 25 wherein the controller is configured to inhibit operation of the heater if an output of the rectal wall blood flow sensor corresponds to a blood flow that is less than a threshold value.

34. A system according to claim 33 wherein the controller is configured to compute the threshold value based at least in part on a magnitude of a peak in a signal derived from an output of the rectal wall blood flow sensor.

35. A system according to claim 33 wherein the controller is configured to compute the threshold value based at least in part on a magnitude of a signal derived from an output of the rectal wall blood flow sensor at a time before commencing heating.

36. A system according to claim 35 comprising a memory wherein the controller is configured to store a value representing the magnitude of the signal derived from the output of the rectal wall blood flow sensor in the memory.

37. A system according to claim 33 wherein the controller is configured to compute the threshold value based at least in part on a value of the output of the rectal wall blood flow sensor at a time when a rate of change of the value of the output of the rectal wall blood flow sensor exceeds a second threshold.

38. A system according to claim 25 comprising a readout configured to display an indication of a rectal wall blood flow as determined from an output of the rectal wall blood flow sensor.

39. A system according to claim 18 wherein the controller is configured to operate the heater to apply heat to tissues of the subject'"'"'s prostate during periods in which blood flow as determined by the blood flow sensor is below a threshold value and to not apply heat during periods wherein the blood flow determined by the blood flow sensor exceeds the threshold value.

40. A system according to claim 1 comprising a readout configured to display a blood flow based on an output of the blood flow sensor.

41. A system according to claim 18 wherein the heater comprises a microwave heater.

42. A system according to claim 18 comprising a blood flow control mechanism wherein the system is configured to operate the blood flow control mechanism to reduce a blood flow to the subject'"'"'s prostate while operating the heater.

43. A catheter useful for measuring blood flow in a subject'"'"'s prostate gland, the catheter comprising:

an elongated catheter body sized and configured such that, when placed within the urinary tract of a male individual, a proximal portion of the catheter body resides outside the body of the individual, a middle portion of the catheter body resides within a urethra of the individual and a distal portion of the catheter body comprising an anchor resides within a urinary bladder of the individual; and

,

a blood flow sensor supported by the middle portion of the catheter body at a location spaced apart from the anchor.

44. Apparatus for applying thermal treatment to a subject'"'"'s prostate gland, the system comprising:

a rectal probe comprising a rectal wall blood flow sensor;

a tissue heating system;

a control controlling operation of the tissue heating system and connected to receive a rectal wall blood flow signal output by the rectal wall blood flow sensor;

wherein the control is configured to inhibit operation of the tissue heating system upon determining that the rectal wall blood flow signal satisfies a condition.

45. Apparatus according to claim 44 wherein the condition comprises the rectal-wall-blood-flow signal having fallen to a value that is lower than a threshold.

46. Apparatus according to claim 44 wherein the condition comprises the rectal-wall-blood-flow signal is decreasing with time at a rate exceeding a threshold.

47. (canceled)

48. (canceled)