In-Vivo Non-Invasive Bioelectric Impedance Analysis of Glucose-Mediated Changes in Tissue
First Claim
1. A transdermal test sensor assembly adapted to determine an analyte concentration of a fluid sample, the test sensor assembly comprising:
- a sensor support including at least one reservoir adapted to hold a liquid;
a test sensor being coupled to the sensor support, the test sensor forming at least one aperture therein, at least a portion of the at least one aperture being adjacent to the at least one reservoir; and
a hydrogel composition positioned on the test sensor, the hydrogel composition being linked to the at least one reservoir via the at least one aperture.
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Accused Products
Abstract
A non-invasive, in vivo method for measuring glucose-mediated changes in tissue is disclosed. The method comprises the act of providing a system for directly or indirectly measuring impedance values. The method further comprises the act of providing at least three electrodes and corresponding electrode pads. The electrodes are connected to the system. The method further comprises the act of contacting the electrode pads to a user'"'"'s skin. The method further comprises the act of contacting each of the at least four electrodes to a corresponding electrode pad. The method further comprises the act of applying an alternating current. The method further comprises the act of determining the correlation between the glucose concentration in the tissue and the measured changes in impedance.
12 Citations
18 Claims
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1. A transdermal test sensor assembly adapted to determine an analyte concentration of a fluid sample, the test sensor assembly comprising:
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a sensor support including at least one reservoir adapted to hold a liquid; a test sensor being coupled to the sensor support, the test sensor forming at least one aperture therein, at least a portion of the at least one aperture being adjacent to the at least one reservoir; and a hydrogel composition positioned on the test sensor, the hydrogel composition being linked to the at least one reservoir via the at least one aperture. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A transdermal analyte-testing assembly adapted to determine an analyte concentration of a sample, the analyte-testing assembly comprising:
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a sensor support including at least one reservoir adapted to hold a liquid; a test sensor being coupled to the sensor support, the test sensor forming at least one aperture therein, at least a portion of the at least one aperture being adjacent to the at least one reservoir; a hydrogel composition being linked to the at least one reservoir via the at least one aperture; and an analyte-testing instrument coupled to the sensor support, the analyte-testing instrument being adapted to determine an analyte concentration of a sample. - View Dependent Claims (8, 9, 10, 11, 12)
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13. A non-invasive method of determining a concentration of at least one analyte in a body fluid, the method comprising the acts of:
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providing a transdermal test sensor assembly including a sensor support, a test sensor, and a hydrogel composition, the test sensor support including at least one reservoir, the at least one reservoir including a liquid, the test sensor being coupled to the sensor support, the test sensor forming at least one aperture therein, at least a portion of the at least one aperture being adjacent to the at least one reservoir, the hydrogel composition being linked to the at least one reservoir via the at least one aperture; contacting the transdermal sensor to an area of skin such that the hydrogel composition is positioned between the skin and the test sensor; coupling an analyte-testing instrument to the transdermal test sensor assembly; and determining the concentration of the analyte using the analyte-testing instrument. - View Dependent Claims (14, 15, 16, 17, 18)
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Specification