Device and Methods for Subcutaneous Delivery of High Viscosity Fluids
First Claim
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1. A subcutaneous infusion system comprising:
- a) a needle of 24 to 27 Ga comprising a shaft having an internal duct of unvarying diameter defining a fluid pathway between openings at distal and proximal ends of the needle, and wherein a hub in fluid communication with the duct is disposed at the distal end and the needle length therefrom to the proximal end is about 4 to 6 mm; and
b) a medication dispensing device in detachable fluid communication with the needle duct, the device containing about 3 to 100 mls of a highly viscous therapeutic fluid composition, wherein the system is configured for subcutaneous delivery of the therapeutic fluid composition at a flow rate of about 1-20 mls per minute.
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Abstract
The present invention provides infusion devices and methods for subcutaneous delivery of high viscosity fluids. The devices and methods described are innovative subcutaneous infusion systems that allow for the rapid delivery of viscous therapeutic fluids while avoiding adverse side effects and promoting patient comfort. The devices and methods described are also useful for rapid delivery of high volumes of therapeutic fluids.
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Citations
35 Claims
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1. A subcutaneous infusion system comprising:
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a) a needle of 24 to 27 Ga comprising a shaft having an internal duct of unvarying diameter defining a fluid pathway between openings at distal and proximal ends of the needle, and wherein a hub in fluid communication with the duct is disposed at the distal end and the needle length therefrom to the proximal end is about 4 to 6 mm; and b) a medication dispensing device in detachable fluid communication with the needle duct, the device containing about 3 to 100 mls of a highly viscous therapeutic fluid composition, wherein the system is configured for subcutaneous delivery of the therapeutic fluid composition at a flow rate of about 1-20 mls per minute. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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32. A method for subcutaneous delivery of a high volume of a therapeutic fluid to a subject in need thereof comprising administering to the subject a therapeutic fluid using a subcutaneous infusion system comprising:
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a) a needle of 18 Ga comprising a shaft having an internal duct of unvarying diameter defining a fluid pathway between openings at distal and proximal ends of the needle, and wherein a hub in fluid communication with the duct is disposed at the distal end and the needle length therefrom to the proximal end is about 4 to 6 mm; and b) a medication dispensing device in detachable fluid communication with the needle duct, the device containing about 3 to 100 mls of a highly viscous therapeutic fluid composition, wherein the fluid is administered at a flow rate greater than about 20 ml/min. - View Dependent Claims (33, 34, 35)
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Specification