ELECTROPORATION ABLATION APPARATUS, SYSTEM, AND METHOD
First Claim
1. A method comprising:
- receiving image information of a diseased tissue region in a patient;
determining a volume and outline of a necrotic zone required to treat the diseased tissue based on the image information; and
determining waveform parameters to be generated by an electrical waveform generator suitable to destroy the diseased tissue located between first and second electrodes wherein the first and second electrodes are adapted to couple to the electrical waveform generator to receive an irreversible electroporation electrical waveform sufficient to ablate tissue located between the first and second electrodes.
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Accused Products
Abstract
A surgical instrument, such as an endoscopic or laparoscopic instrument, includes an ablation device. The ablation device includes an elongate relatively flexible member having a proximal end and a distal end, the flexible member includes at least a first working channel. A first and second electrode extends from a working channel at the distal end of the flexible member. The first and second electrodes are adapted to be endoscopically located in a tissue treatment region. The first and second electrodes are adapted to couple to an electrical waveform generator to receive an irreversible electroporation electrical waveform sufficient to ablate tissue located between the first and second electrodes. The waveform parameters of the irreversible electroporation electrical waveform are determined based on image information received from the tissue treatment region.
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Citations
20 Claims
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1. A method comprising:
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receiving image information of a diseased tissue region in a patient; determining a volume and outline of a necrotic zone required to treat the diseased tissue based on the image information; and determining waveform parameters to be generated by an electrical waveform generator suitable to destroy the diseased tissue located between first and second electrodes wherein the first and second electrodes are adapted to couple to the electrical waveform generator to receive an irreversible electroporation electrical waveform sufficient to ablate tissue located between the first and second electrodes. - View Dependent Claims (2, 3, 4)
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5. An ablation system comprising:
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an elongate member having a proximal end and a distal end, and comprising first and second working channels formed within the flexible member; a first electrode extending from the first working channel at the distal end of the flexible member, and second electrode extending from the second working channel, the first and second electrodes are adapted to be endoscopically located in a diseased tissue region; an image processing module; an electrical waveform generator electrically coupled to the first and second electrodes and the image processing module, to generate an irreversible electroporation electrical (IRE) waveform based on waveform parameters, wherein the IRE waveform is sufficient to ablate tissue located between the first and second electrodes, wherein the electrical waveform generator is adapted to receive the waveform parameters from the image processing module, and wherein the waveform parameters are determined based on image information of the diseased tissue region in a patient. - View Dependent Claims (6, 7, 8, 9, 10, 11, 12)
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13. A method comprising:
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receiving first image information of a diseased tissue in a patient; creating a virtual model of the diseased tissue; determining a first size of a necrotic zone required to treat the diseased tissue based on the first image information; and determining a first set of waveform parameters of an irreversible electroporation electrical (IRE) waveform to be generated by an electrical waveform generator suitable to destroy the diseased tissue located between first and second electrodes wherein the first and second electrodes are adapted to couple to the electrical waveform generator to receive the irreversible electroporation electrical waveform. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20)
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Specification