Cell-Scaffold Constructs
First Claim
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1. A urinary diversion for a defective bladder in a subject comprisinga) a first implantable, biocompatible construct comprising a tubular scaffold having a first end configured to connect to an abdominal wall section, a second closed end, and at least a first side opening configured to connect to a first ureter;
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Accused Products
Abstract
The present invention relates to the regeneration, reconstruction, repair, augmentation or replacement of organs or tissue structures using scaffolds and autologous cells that are not derived from such organs or tissues.
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Citations
55 Claims
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1. A urinary diversion for a defective bladder in a subject comprising
a) a first implantable, biocompatible construct comprising a tubular scaffold having a first end configured to connect to an abdominal wall section, a second closed end, and at least a first side opening configured to connect to a first ureter; - and
b) an autologous cell population that is not derived from the defective bladder, deposited on or in a surface of the scaffold. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method of preparing a urinary diversion construct for a defective bladder in a subject in need comprising
a) providing a first implantable biocompatible scaffold comprising a tubular scaffold having a first end configured to contact an abdominal wall section, a second closed end, and at least a first side opening configured to connect to a first ureter; - and
b) depositing an autologous cell population that is not derived from the defective bladder on or in a first area of said scaffold to form a urinary diversion construct. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34)
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35. A method of providing a urinary diversion for a defective bladder in a subject in need comprising
a) providing a first implantable biocompatible scaffold comprising a tubular scaffold having a first end configured to connect to an abdominal wall section, a second closed end, and at least a first side opening configured to connect to a first ureter; - and
b) depositing an autologous cell population that is not derived from the defective bladder on or in a first area of said scaffold to form a urinary diversion construct; and c) implanting the construct into said subject for the formation of the urinary diversion. - View Dependent Claims (37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55)
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36. A method of providing a urinary diversion for a defective bladder in a subject in need comprising implanting into said subject a urinary diversion construct comprising (a) a tubular scaffold having a first end configured to contact an abdominal wall section, a second closed end, and at least a first side opening configured to connect to a first ureter;
- and (b) an autologous cell population that is not derived from the defective bladder, deposited on or in a surface of the scaffold, for the formation of the urinary diversion.
Specification