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AUTOMATIC ISOTHERMAL TITRATION MICROCALORIMETER APPARATUS AND METHOD OF USE

  • US 20100135853A1
  • Filed: 12/02/2008
  • Published: 06/03/2010
  • Est. Priority Date: 12/02/2008
  • Status: Active Grant
First Claim
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1. An automated isothermal titration micro calorimetry (ITC) system comprising:

  • a micro calorimeter with a sample cell and a reference cell, the sample cell is accessible via a sample cell stem and the reference cell is accessible via a reference cell stem;

    an automatic pipette assembly comprising a syringe with a titration needle arranged to be inserted into the sample cell for supplying titrant, the pipette assembly comprises an activator for driving a plunger in the syringe;

    a pipette translation unit supporting the pipette assembly and being arranged to place pipette in position for titration, washing and filling operations;

    a wash station for the titrant needle; and

    a cell preparation unit arranged to perform operations for replacing the sample liquid in the sample cell when the pipette is placed in another position than the position for titration.

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