Ship Inhibition to Direct Hematopoietic Stem Cells and Induce Extramedullary Hematopoiesis
First Claim
1. A method for directing hematopoietic stem cells (HSC) from bone marrow to another site in the body of a person or animal, wherein said method comprises inhibiting SHIP expression and/or SHIP function or activity in a cell of the person or animal, such that the HSC are directed to another site in the body.
3 Assignments
0 Petitions
Accused Products
Abstract
The present invention concerns inhibition of SHIP expression and/or function in mammalian subjects to direct HSC from the bone marrow to other sites in the body (such as the spleen and/or liver), where they then re-establish blood cell production. The method of the invention can be employed, for example, to rescue or enhance blood cell recovery during bone marrow impairment due to bone-seeking radioisotope exposure, chemotherapy, radiotherapy, infection, or genetic or congenital defects. Preferably, inhibition of SHIP expression and/or function is achieved by administering an effective amount of one or more SHIP inhibitors to the subject. In one embodiment, the subject is suffering from, or at risk of developing, bone marrow failure (such as an aplastic bone marrow failure syndrome). In another embodiment, the subject is suffering from, or at risk of, exposure to a bone-seeking radioisotope. In another embodiment, the subject is suffering from, or at risk of developing, fibrotic or damaged bone marrow due to chemotherapy and/or radiation therapy for cancer.
16 Citations
47 Claims
- 1. A method for directing hematopoietic stem cells (HSC) from bone marrow to another site in the body of a person or animal, wherein said method comprises inhibiting SHIP expression and/or SHIP function or activity in a cell of the person or animal, such that the HSC are directed to another site in the body.
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- 17. A method for rescuing or enhancing blood cell recovery during bone marrow impairment in a person or animal, wherein said method comprises inhibiting SHIP expression and/or SHIP function or activity in a cell of the person or animal.
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- 33. A method for treating or delaying the onset of impaired bone marrow function in a person or animal, wherein said method comprises administering a therapeutically effective amount of a SHIP inhibitor to a person or animal in need of treatment.
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Specification