Polymeric Coatings that Inactivate Viruses and Bacteria

• US 20100136072A1
• Filed: 11/08/2007
• Published: 06/03/2010
• Est. Priority Date: 11/08/2006
• Status: Abandoned Application

• Current Assignee: Massachusetts Institute of Technology
• Original Assignee: Massachusetts Institute of Technology
• Inventors: de Cienguegos, Luis Álvarez, Haldar, Jayanta, An, Deqiang, Chen, Jianzhu, Klibanov, Alexander M.
• Application Number:
  US12/514,101
• Publication Number:
  US 20100136072A1
• Time in Patent Office: Days
• US Class Current: 424/402
• CPC Class Codes: A01N 25/10 Macromolecular compounds
• CPC Class Codes: A01N 33/04 Nitrogen directly attached to aliphatic or cycloaliphatic carbon atoms
• CPC Class Codes: A01N 33/12 Quaternary ammonium compounds
• CPC Class Codes: A01N 37/18 containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
• CPC Class Codes: A01N 43/40 six-membered rings
• CPC Class Codes: A01N 57/34 having phosphorus-to-halogen bonds; Phosphonium salts
• CPC Class Codes: A61P 31/12 Antivirals
• CPC Class Codes: C09D 179/02 Polyamines
• CPC Class Codes: C09D 5/14 Paints containing biocides, e.g. fungicides, insecticides or pesticides C09D5/16 takes precedence

Abstract

Hydrophobic polymeric coatings which can be non-covalently applied to solid surfaces such as metals, plastics, glass, polymers, textiles, and other substrates such as fabrics, gauze, bandages, tissues, and other fibers, in the same manner as paint, for example, by brushing, spraying, or dipping, to make the surfaces virucidal and bactericidal, have been developed.

Claims

1. A virucidal composition comprising a coating comprising a hydrophobic, water-insoluble polymer deposited on an inert surface, wherein if the polymer is a cationic polymer, the polymer is selected from the group consisting of polymers of Formula I

wherein R₁-R₆ are alkyl groups,

polymers of Formula II

wherein R₁-R₃ are alkyl groups, and

polymers of Formula III,

wherein R₁-R₃ are alkyl groups.

2. The composition of claim 1, wherein the coating associates with the surface via non-covalent interactions.

3. The composition of claim 1, wherein the polymer is anionic.

4. The composition of claim 1 wherein the polymer is zwitterionic.

5. The composition of claim 1 wherein the polymer has a molecular weight of at least 20 kDa.

6. The composition of claim 1, wherein the polymer has a molecular weight of at least 50 kDa.

7. The composition of claim 1, wherein the polymer has a molecular weight of at least 100 kDa.

8. The composition of claim 5, wherein the polymer is a zwitterionic polymer having a structure selected from the group consisting of:

9. The composition of claim 1, wherein the coating is applied to the surface by painting, brushing, dipping, or spraying.

10. The composition of claim 1, wherein the surface is formed of a material selected from the group consisting of metals, ceramics, glass, polymers, plastics, and fibers.

11. The composition of claim 1, wherein the surface is the surface of a device or implant to be placed into a body or tissue.

12. The composition of claim 1, wherein the surface is the surface of a fabric, gauze, tissue, surgical drape, air filter, tubing, or surgical instrument.

13. The composition of claim 1, wherein the surface is the surface of a toy, a bathroom fixture, countertop, tabletop, handle, computer, military gear, clothing, paper product, window, door, or interior wall.

14. A method for killing viruses comprising providing the composition of claim 1.

15. The method of claim 14, wherein the virus is an enveloped virus.

16. The method of claim 14, wherein the virus is influenza.

17. The method of claim 14, wherein the surface is the surface of a material selected from the group consisting of metals, ceramics, glass, polymers, and fibers.

18. The method of claim 14, wherein the surface is the surface of a device or implant to be placed into a body or tissue.

19. The method of claim 14, wherein the surface is the surface of fabric, gauze, tissue, surgical drape, air filter, tubing, or surgical instrument.

20. The method of claim 14, wherein the surface is the surface of a toy, a bathroom fixture, countertop, tabletop, handle, computer, military gear, clothing, paper product, window, door, or interior wall.